Aarhus Universitets segl

Ping Song

Transdermal Delivery of Therapeutic Compounds With Nanotechnological Approaches in Psoriasis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review


  • Ning Li, Chinese Academy of Medical Sciences
  • ,
  • Yeping Qin, Chinese Academy of Medical Sciences
  • ,
  • Dan Dai, Chinese Academy of Medical Sciences
  • ,
  • Pengyu Wang, Chinese Academy of Medical Sciences
  • ,
  • Mingfei Shi, Chinese Academy of Medical Sciences
  • ,
  • Junwei Gao, Chinese Academy of Medical Sciences
  • ,
  • Jinsheng Yang, Chinese Academy of Medical Sciences
  • ,
  • Wei Xiao, Jiangsu Kanion Pharmaceutical Co., Ltd.
  • ,
  • Ping Song
  • Ruodan Xu, Chinese Academy of Medical Sciences

Psoriasis is a chronic, immune-mediated skin disorder involving hyperproliferation of the keratinocytes in the epidermis. As complex as its pathophysiology, the optimal treatment for psoriasis remains unsatisfactorily addressed. Though systemic administration of biological agents has made an impressive stride in moderate-to-severe psoriasis, a considerable portion of psoriatic conditions were left unresolved, mainly due to adverse effects from systemic drug administration or insufficient drug delivery across a highly packed stratum corneum via topical therapies. Along with the advances in nanotechnologies, the incorporation of nanomaterials as topical drug carriers opens an obvious prospect for the development of antipsoriatic topicals. Hence, this review aims to distinguish the benefits and weaknesses of individual nanostructures when applied as topical antipsoriatics in preclinical psoriatic models. In view of specific features of each nanostructure, we propose that a proper combination of distinctive nanomaterials according to the physicochemical properties of loaded drugs and clinical features of psoriatic patients is becoming a promising option that potentially drives the translation of nanomaterials from bench to bedside with improved transdermal drug delivery and consequently therapeutic effects.

TidsskriftFrontiers in Bioengineering and Biotechnology
Antal sider29
StatusUdgivet - jan. 2022

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