-
Uddannelse
Find uddannelse
Studievejledning
Kvalitet
- Forskning
-
Samarbejde
Virksomheder
Kommuner og regioner
Gymnasier
Myndigheder
-
Om AU
Organisation
Kontakt
Om AU
- Organisation
- Ledelse
- Strategi
- AU i tal
- AU's historie
- Internationalt samarbejde
- Bæredygtighed
- Campus 2.0
- Diversitet og ligestilling
- Ledige stillinger
- Presse
- Kontakt
Ping Song
Lipidoid-siRNA Nanoparticle-Mediated IL-1 beta Gene Silencing for Systemic Arthritis Therapy in a Mouse Model
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1016/j.ymthe.2019.05.002
Forlagets udgivne version
- Ping Song
- Chuanxu Yang ,
- Jesper Skovhus Thomsen
- Frederik Dagnaes-Hansen ,
- Maria Jakobsen ,
- Annemarie Bruel
- Bent Deleuran
- Jorgen Kjems
- Interdisciplinary Nanoscience Center - INANO-MBG, iNANO-huset
- Institut for Molekylærbiologi og Genetik
- Institut for Biomedicin - Forskning og uddannelse, Syd
- Institut for Biomedicin - Dyrestald
- Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen
- Institut for Klinisk Medicin - Led- og Bindevævssygdomme
- Institut for Molekylærbiologi og Genetik - RNA-biologi og -innovation
Interleukin-1 beta (IL-1 beta) plays a central role in the induction of rheumatoid arthritis (RA). In the present study, we demonstrated that lipidoid-polymer hybrid nanoparticle (FS14-NP) can efficiently deliver siRNA against IL-1 beta (siIL-1 beta) to macrophages and effectively suppress the pathogenesis of experimental arthritis induced by collagen antibody (CAIA mice). FS14-NP/siIL-1 beta achieved approximately 70% and 90% genesilencing efficiency in the RAW 264.7 cell line and intraperitoneal macrophages, respectively. Intravenous administration of FS14-NP/siRNA led to rapid accumulation of siRNA in macrophages within the arthritic joints. Furthermore, FS14-NP/siIL1 beta treatment lowered the expression of pro-inflammatory cytokines in arthritic joints and dramatically attenuated ankle swelling, bone erosion, and cartilage destruction. These results demonstrate that FS14-NP/siIL-1 beta may represent an effective therapy for systemic arthritis and other inflammatory disorders.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Molecular Therapy |
| Vol/bind | 27 |
| Nummer | 8 |
| Sider (fra-til) | 1424-1435 |
| Antal sider | 12 |
| ISSN | 1525-0016 |
| DOI | |
| Status | Udgivet - 2019 |
Se relationer på Aarhus Universitet Citationsformater
ID: 162530706