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Peter Vedsted

Visualization of Coronary Artery Calcification: Influence on Risk Modification

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Visualization of Coronary Artery Calcification : Influence on Risk Modification. / Mols, Rikke Elmose; Møller Jensen, Jesper; Sand, Niels Peter; Fuglesang, Charlotte; Bagdat, Døne; Vedsted, Peter; Bøtker, Hans Erik; Nielsen, Lene Hüche; Nørgaard, Bjarne Linde.

I: The American Journal of Medicine, 21.04.2015.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Mols, Rikke Elmose ; Møller Jensen, Jesper ; Sand, Niels Peter ; Fuglesang, Charlotte ; Bagdat, Døne ; Vedsted, Peter ; Bøtker, Hans Erik ; Nielsen, Lene Hüche ; Nørgaard, Bjarne Linde. / Visualization of Coronary Artery Calcification : Influence on Risk Modification. I: The American Journal of Medicine. 2015.

Bibtex

@article{43394203d61447b58b51b5447b59556b,
title = "Visualization of Coronary Artery Calcification: Influence on Risk Modification",
abstract = "BACKGROUND: Direct health provider to patient presentation of coronary computed tomography angiography (CTA) findings may increase adherence to preventive therapy and risk modification. The purpose of this study was to assess the influence of visualization of coronary artery calcification and lifestyle recommendations on cholesterol concentrations and other risk variables in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia.METHODS: Prospective two-center randomized controlled trial. Patients were randomized 1:1 to intervention or standard follow-up in general practice. The primary end-point was change in plasma total-cholesterol concentration at 6-months follow-up.RESULTS: We included 189 patients (mean [± SD] age 61 [12] years, 57{\%} males). Median (range) Agatston score was 166 (70-2054). The reduction in plasma total-cholesterol concentrations tended to be higher in the intervention than in the control group, 51.04 mg/dL vs. 45.63 mg/dL (P = 0.181). In a subgroup including patients continuing statin therapy during follow-up (n = 147), the reduction in plasma total-cholesterol concentrations was more pronounced in the intervention than in the control group, 66.13 mg/dL vs. 55.68 mg/dL (P = 0.027). In the intervention group there was a higher degree of statin adherence and a higher proportion of patients who stopped smoking and commenced a healthier dietary behavior than in the control group.CONCLUSION: Visualization of coronary artery calcification and brief recommendations about risk modification after coronary CTA in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia may have a favorable influence on plasma total-cholesterol concentration, adherence to statin therapy and risk behavior. Further investigations are needed.",
author = "Mols, {Rikke Elmose} and {M{\o}ller Jensen}, Jesper and Sand, {Niels Peter} and Charlotte Fuglesang and D{\o}ne Bagdat and Peter Vedsted and B{\o}tker, {Hans Erik} and Nielsen, {Lene H{\"u}che} and N{\o}rgaard, {Bjarne Linde}",
note = "Copyright {\circledC} 2015 Elsevier Inc. All rights reserved.",
year = "2015",
month = "4",
day = "21",
doi = "10.1016/j.amjmed.2015.03.033",
language = "English",
journal = "American Journal of Medicine",
issn = "0002-9343",
publisher = "Elsevier Inc",

}

RIS

TY - JOUR

T1 - Visualization of Coronary Artery Calcification

T2 - Influence on Risk Modification

AU - Mols, Rikke Elmose

AU - Møller Jensen, Jesper

AU - Sand, Niels Peter

AU - Fuglesang, Charlotte

AU - Bagdat, Døne

AU - Vedsted, Peter

AU - Bøtker, Hans Erik

AU - Nielsen, Lene Hüche

AU - Nørgaard, Bjarne Linde

N1 - Copyright © 2015 Elsevier Inc. All rights reserved.

PY - 2015/4/21

Y1 - 2015/4/21

N2 - BACKGROUND: Direct health provider to patient presentation of coronary computed tomography angiography (CTA) findings may increase adherence to preventive therapy and risk modification. The purpose of this study was to assess the influence of visualization of coronary artery calcification and lifestyle recommendations on cholesterol concentrations and other risk variables in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia.METHODS: Prospective two-center randomized controlled trial. Patients were randomized 1:1 to intervention or standard follow-up in general practice. The primary end-point was change in plasma total-cholesterol concentration at 6-months follow-up.RESULTS: We included 189 patients (mean [± SD] age 61 [12] years, 57% males). Median (range) Agatston score was 166 (70-2054). The reduction in plasma total-cholesterol concentrations tended to be higher in the intervention than in the control group, 51.04 mg/dL vs. 45.63 mg/dL (P = 0.181). In a subgroup including patients continuing statin therapy during follow-up (n = 147), the reduction in plasma total-cholesterol concentrations was more pronounced in the intervention than in the control group, 66.13 mg/dL vs. 55.68 mg/dL (P = 0.027). In the intervention group there was a higher degree of statin adherence and a higher proportion of patients who stopped smoking and commenced a healthier dietary behavior than in the control group.CONCLUSION: Visualization of coronary artery calcification and brief recommendations about risk modification after coronary CTA in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia may have a favorable influence on plasma total-cholesterol concentration, adherence to statin therapy and risk behavior. Further investigations are needed.

AB - BACKGROUND: Direct health provider to patient presentation of coronary computed tomography angiography (CTA) findings may increase adherence to preventive therapy and risk modification. The purpose of this study was to assess the influence of visualization of coronary artery calcification and lifestyle recommendations on cholesterol concentrations and other risk variables in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia.METHODS: Prospective two-center randomized controlled trial. Patients were randomized 1:1 to intervention or standard follow-up in general practice. The primary end-point was change in plasma total-cholesterol concentration at 6-months follow-up.RESULTS: We included 189 patients (mean [± SD] age 61 [12] years, 57% males). Median (range) Agatston score was 166 (70-2054). The reduction in plasma total-cholesterol concentrations tended to be higher in the intervention than in the control group, 51.04 mg/dL vs. 45.63 mg/dL (P = 0.181). In a subgroup including patients continuing statin therapy during follow-up (n = 147), the reduction in plasma total-cholesterol concentrations was more pronounced in the intervention than in the control group, 66.13 mg/dL vs. 55.68 mg/dL (P = 0.027). In the intervention group there was a higher degree of statin adherence and a higher proportion of patients who stopped smoking and commenced a healthier dietary behavior than in the control group.CONCLUSION: Visualization of coronary artery calcification and brief recommendations about risk modification after coronary CTA in symptomatic patients with non-obstructive coronary artery disease and hyperlipidemia may have a favorable influence on plasma total-cholesterol concentration, adherence to statin therapy and risk behavior. Further investigations are needed.

U2 - 10.1016/j.amjmed.2015.03.033

DO - 10.1016/j.amjmed.2015.03.033

M3 - Journal article

JO - American Journal of Medicine

JF - American Journal of Medicine

SN - 0002-9343

ER -