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Peter Vedsted

Time from incident primary cancer until recurrence or second primary cancer: Risk factors and impact in general practice

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Time from incident primary cancer until recurrence or second primary cancer : Risk factors and impact in general practice. / Rasmussen, Linda Aagaard; Jensen, Henry; Virgilsen, Line Flytkjaer; Falborg, Alina Zalounina; Møller, Henrik; Vedsted, Peter.

I: European Journal of Cancer Care, Bind 28, Nr. 5, e13123, 09.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{e1e6960cec2545ce8d7e0b722d487fe6,
title = "Time from incident primary cancer until recurrence or second primary cancer: Risk factors and impact in general practice",
abstract = "OBJECTIVE: Specialised follow-up care after cancer treatment is changing towards increased involvement of general practice. To ensure timely detection of new cancer events, knowledge is warranted on the timing of cancer recurrence (CR) and second primary cancer (SPC), including risk factors for CR.METHODS: This population-based register study included 67,092 patients diagnosed with malignant melanoma, bladder, lung, ovarian, endometrial, colorectal and breast cancer in Denmark in 2008-2016. The time from primary cancer to CR or SPC and risk factors for prolonged time to CR were analysed and stratified on sex and primary cancer type.RESULTS: Cancer recurrence proportions ranged from 6% to 35%. The risk of CR increased profoundly within the first 3 years and then levelled off, except for breast cancer. A total of 3%-6% of patients had SPC, with monotonously increasing cumulative incidence proportions. Besides primary tumour characteristics, lower educational level, living alone and comorbidity were associated with earlier CR. For example, in female malignant melanoma, HRs and 95% confidence intervals were 0.47 (0.37-0.61) for high educational level, 1.40 (1.16-1.68) for living alone and 2.38 (1.53-3.70) for high comorbidity.CONCLUSION: The results may inform stratified risk assessment in decision of frequency, location and duration of post-cancer follow-up care.",
keywords = "cancer survivors, care transition, primary health care, recurrence, second primary neoplasms, BLADDER-CANCER, VALIDATED ALGORITHM, FOLLOW-UP, PATTERNS, STAGE-II, BREAST-CANCER, PRIMARY-CARE, COLORECTAL-CANCER, HEALTH, SURVIVORS",
author = "Rasmussen, {Linda Aagaard} and Henry Jensen and Virgilsen, {Line Flytkjaer} and Falborg, {Alina Zalounina} and Henrik M{\o}ller and Peter Vedsted",
note = "{\textcopyright} 2019 John Wiley & Sons Ltd.",
year = "2019",
month = sep,
doi = "10.1111/ecc.13123",
language = "English",
volume = "28",
journal = "European Journal of Cancer Care",
issn = "0961-5423",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "5",

}

RIS

TY - JOUR

T1 - Time from incident primary cancer until recurrence or second primary cancer

T2 - Risk factors and impact in general practice

AU - Rasmussen, Linda Aagaard

AU - Jensen, Henry

AU - Virgilsen, Line Flytkjaer

AU - Falborg, Alina Zalounina

AU - Møller, Henrik

AU - Vedsted, Peter

N1 - © 2019 John Wiley & Sons Ltd.

PY - 2019/9

Y1 - 2019/9

N2 - OBJECTIVE: Specialised follow-up care after cancer treatment is changing towards increased involvement of general practice. To ensure timely detection of new cancer events, knowledge is warranted on the timing of cancer recurrence (CR) and second primary cancer (SPC), including risk factors for CR.METHODS: This population-based register study included 67,092 patients diagnosed with malignant melanoma, bladder, lung, ovarian, endometrial, colorectal and breast cancer in Denmark in 2008-2016. The time from primary cancer to CR or SPC and risk factors for prolonged time to CR were analysed and stratified on sex and primary cancer type.RESULTS: Cancer recurrence proportions ranged from 6% to 35%. The risk of CR increased profoundly within the first 3 years and then levelled off, except for breast cancer. A total of 3%-6% of patients had SPC, with monotonously increasing cumulative incidence proportions. Besides primary tumour characteristics, lower educational level, living alone and comorbidity were associated with earlier CR. For example, in female malignant melanoma, HRs and 95% confidence intervals were 0.47 (0.37-0.61) for high educational level, 1.40 (1.16-1.68) for living alone and 2.38 (1.53-3.70) for high comorbidity.CONCLUSION: The results may inform stratified risk assessment in decision of frequency, location and duration of post-cancer follow-up care.

AB - OBJECTIVE: Specialised follow-up care after cancer treatment is changing towards increased involvement of general practice. To ensure timely detection of new cancer events, knowledge is warranted on the timing of cancer recurrence (CR) and second primary cancer (SPC), including risk factors for CR.METHODS: This population-based register study included 67,092 patients diagnosed with malignant melanoma, bladder, lung, ovarian, endometrial, colorectal and breast cancer in Denmark in 2008-2016. The time from primary cancer to CR or SPC and risk factors for prolonged time to CR were analysed and stratified on sex and primary cancer type.RESULTS: Cancer recurrence proportions ranged from 6% to 35%. The risk of CR increased profoundly within the first 3 years and then levelled off, except for breast cancer. A total of 3%-6% of patients had SPC, with monotonously increasing cumulative incidence proportions. Besides primary tumour characteristics, lower educational level, living alone and comorbidity were associated with earlier CR. For example, in female malignant melanoma, HRs and 95% confidence intervals were 0.47 (0.37-0.61) for high educational level, 1.40 (1.16-1.68) for living alone and 2.38 (1.53-3.70) for high comorbidity.CONCLUSION: The results may inform stratified risk assessment in decision of frequency, location and duration of post-cancer follow-up care.

KW - cancer survivors

KW - care transition

KW - primary health care

KW - recurrence

KW - second primary neoplasms

KW - BLADDER-CANCER

KW - VALIDATED ALGORITHM

KW - FOLLOW-UP

KW - PATTERNS

KW - STAGE-II

KW - BREAST-CANCER

KW - PRIMARY-CARE

KW - COLORECTAL-CANCER

KW - HEALTH

KW - SURVIVORS

UR - http://www.scopus.com/inward/record.url?scp=85068042856&partnerID=8YFLogxK

U2 - 10.1111/ecc.13123

DO - 10.1111/ecc.13123

M3 - Journal article

C2 - 31231898

VL - 28

JO - European Journal of Cancer Care

JF - European Journal of Cancer Care

SN - 0961-5423

IS - 5

M1 - e13123

ER -