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Peter Vedsted

Time from incident primary cancer until recurrence or second primary cancer: Risk factors and impact in general practice

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

OBJECTIVE: Specialised follow-up care after cancer treatment is changing towards increased involvement of general practice. To ensure timely detection of new cancer events, knowledge is warranted on the timing of cancer recurrence (CR) and second primary cancer (SPC), including risk factors for CR.

METHODS: This population-based register study included 67,092 patients diagnosed with malignant melanoma, bladder, lung, ovarian, endometrial, colorectal and breast cancer in Denmark in 2008-2016. The time from primary cancer to CR or SPC and risk factors for prolonged time to CR were analysed and stratified on sex and primary cancer type.

RESULTS: Cancer recurrence proportions ranged from 6% to 35%. The risk of CR increased profoundly within the first 3 years and then levelled off, except for breast cancer. A total of 3%-6% of patients had SPC, with monotonously increasing cumulative incidence proportions. Besides primary tumour characteristics, lower educational level, living alone and comorbidity were associated with earlier CR. For example, in female malignant melanoma, HRs and 95% confidence intervals were 0.47 (0.37-0.61) for high educational level, 1.40 (1.16-1.68) for living alone and 2.38 (1.53-3.70) for high comorbidity.

CONCLUSION: The results may inform stratified risk assessment in decision of frequency, location and duration of post-cancer follow-up care.

OriginalsprogEngelsk
Artikelnummere13123
TidsskriftEuropean Journal of Cancer Care
Vol/bind28
Nummer5
Antal sider16
ISSN1365-2354
DOI
StatusUdgivet - sep. 2019

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© 2019 John Wiley & Sons Ltd.

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