Peter Vedsted

The association between socioeconomic position and tumour size, grade, stage, and mortality in Danish sarcoma patients - A national, observational study from 2000 to 2013

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The association between socioeconomic position and tumour size, grade, stage, and mortality in Danish sarcoma patients - A national, observational study from 2000 to 2013. / Raedkjaer, Mathias; Maretty-Kongstad, Katja; Baad-Hansen, Thomas; Safwat, Akmal; Petersen, Michael Mork; Keller, Johnny; Vedsted, Peter.

I: Acta Oncologica, Bind 59, Nr. 2, 02.2020, s. 127-133.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{b0b1ba61561a4359b0d9c1a2490e2f1b,
title = "The association between socioeconomic position and tumour size, grade, stage, and mortality in Danish sarcoma patients - A national, observational study from 2000 to 2013",
abstract = "Background: Survival in sarcoma patients depends on a range of prognostic factors. An association between cancer survival and socioeconomic position is known for several other cancers. We therefore examined the relations between three socioeconomic factors and risk of presenting with known tumour related prognostic factors, and the overall mortality of the different socioeconomic and prognostic factors in 1919 patients diagnosed with sarcoma in Denmark 2000–2013. Material and methods: Patients with sarcoma in extremities or trunk wall aged 30 years or more at diagnosis were identified in the Danish Sarcoma Registry and linked on an individual level to Danish national registries. We obtained data on educational level, disposable income and cohabitation status. Odds ratios (ORs) were estimated for the association between the socioeconomic factors and grade, stage and tumour size. Hazard ratios (HRs) were estimated using Cox proportional hazard models. Results: In adjusted analyses, educational level, income and cohabitation status were not associated with high grade or dissiminated stage at time of diagnosis. However, living alone was statistically significantly associated with having a large soft tissue sarcoma (≥5 cm) at time of diagnosis (OR 1.51; CI1.12–2.03). The overall mortality was statistically significantly increased in the group of patients with ≤10 years of education (HR 1.27; CI 1.02–1.57), in patients with the 20{\%} lowest income (HR 1.30; CI 1.00–1.67) and nearly in patients living alone (HR 1.16; CI 0.99–1.36). Conclusion: In this nationwide, multicentre, population-based study, soft tissue sarcoma patients living alone had greater risk of having a large tumour at time of diagnosis. Soft tissue and bone sarcoma patients with a short education, low income, or living alone, had a higher mortality. This might indicate that the social differences in mortality might be related to treatment aspects and the biology of the disease rather that the diagnostic process.",
keywords = "SOFT-TISSUE SARCOMAS, PROGNOSTIC-FACTORS, CANCER-PATIENTS, NECK-CANCER, SURVIVAL, RISK, COMORBIDITY, IMPACT, OSTEOSARCOMA, EPIDEMIOLOGY",
author = "Mathias Raedkjaer and Katja Maretty-Kongstad and Thomas Baad-Hansen and Akmal Safwat and Petersen, {Michael Mork} and Johnny Keller and Peter Vedsted",
year = "2020",
month = "2",
doi = "10.1080/0284186X.2019.1686536",
language = "English",
volume = "59",
pages = "127--133",
journal = "Acta Oncologica",
issn = "0284-186X",
publisher = "Taylor & Francis",
number = "2",

}

RIS

TY - JOUR

T1 - The association between socioeconomic position and tumour size, grade, stage, and mortality in Danish sarcoma patients - A national, observational study from 2000 to 2013

AU - Raedkjaer, Mathias

AU - Maretty-Kongstad, Katja

AU - Baad-Hansen, Thomas

AU - Safwat, Akmal

AU - Petersen, Michael Mork

AU - Keller, Johnny

AU - Vedsted, Peter

PY - 2020/2

Y1 - 2020/2

N2 - Background: Survival in sarcoma patients depends on a range of prognostic factors. An association between cancer survival and socioeconomic position is known for several other cancers. We therefore examined the relations between three socioeconomic factors and risk of presenting with known tumour related prognostic factors, and the overall mortality of the different socioeconomic and prognostic factors in 1919 patients diagnosed with sarcoma in Denmark 2000–2013. Material and methods: Patients with sarcoma in extremities or trunk wall aged 30 years or more at diagnosis were identified in the Danish Sarcoma Registry and linked on an individual level to Danish national registries. We obtained data on educational level, disposable income and cohabitation status. Odds ratios (ORs) were estimated for the association between the socioeconomic factors and grade, stage and tumour size. Hazard ratios (HRs) were estimated using Cox proportional hazard models. Results: In adjusted analyses, educational level, income and cohabitation status were not associated with high grade or dissiminated stage at time of diagnosis. However, living alone was statistically significantly associated with having a large soft tissue sarcoma (≥5 cm) at time of diagnosis (OR 1.51; CI1.12–2.03). The overall mortality was statistically significantly increased in the group of patients with ≤10 years of education (HR 1.27; CI 1.02–1.57), in patients with the 20% lowest income (HR 1.30; CI 1.00–1.67) and nearly in patients living alone (HR 1.16; CI 0.99–1.36). Conclusion: In this nationwide, multicentre, population-based study, soft tissue sarcoma patients living alone had greater risk of having a large tumour at time of diagnosis. Soft tissue and bone sarcoma patients with a short education, low income, or living alone, had a higher mortality. This might indicate that the social differences in mortality might be related to treatment aspects and the biology of the disease rather that the diagnostic process.

AB - Background: Survival in sarcoma patients depends on a range of prognostic factors. An association between cancer survival and socioeconomic position is known for several other cancers. We therefore examined the relations between three socioeconomic factors and risk of presenting with known tumour related prognostic factors, and the overall mortality of the different socioeconomic and prognostic factors in 1919 patients diagnosed with sarcoma in Denmark 2000–2013. Material and methods: Patients with sarcoma in extremities or trunk wall aged 30 years or more at diagnosis were identified in the Danish Sarcoma Registry and linked on an individual level to Danish national registries. We obtained data on educational level, disposable income and cohabitation status. Odds ratios (ORs) were estimated for the association between the socioeconomic factors and grade, stage and tumour size. Hazard ratios (HRs) were estimated using Cox proportional hazard models. Results: In adjusted analyses, educational level, income and cohabitation status were not associated with high grade or dissiminated stage at time of diagnosis. However, living alone was statistically significantly associated with having a large soft tissue sarcoma (≥5 cm) at time of diagnosis (OR 1.51; CI1.12–2.03). The overall mortality was statistically significantly increased in the group of patients with ≤10 years of education (HR 1.27; CI 1.02–1.57), in patients with the 20% lowest income (HR 1.30; CI 1.00–1.67) and nearly in patients living alone (HR 1.16; CI 0.99–1.36). Conclusion: In this nationwide, multicentre, population-based study, soft tissue sarcoma patients living alone had greater risk of having a large tumour at time of diagnosis. Soft tissue and bone sarcoma patients with a short education, low income, or living alone, had a higher mortality. This might indicate that the social differences in mortality might be related to treatment aspects and the biology of the disease rather that the diagnostic process.

KW - SOFT-TISSUE SARCOMAS

KW - PROGNOSTIC-FACTORS

KW - CANCER-PATIENTS

KW - NECK-CANCER

KW - SURVIVAL

KW - RISK

KW - COMORBIDITY

KW - IMPACT

KW - OSTEOSARCOMA

KW - EPIDEMIOLOGY

U2 - 10.1080/0284186X.2019.1686536

DO - 10.1080/0284186X.2019.1686536

M3 - Journal article

C2 - 31702424

VL - 59

SP - 127

EP - 133

JO - Acta Oncologica

JF - Acta Oncologica

SN - 0284-186X

IS - 2

ER -