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Peter Vedsted

Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status : National cohort study in England. / Møller, Henrik; Henson, Katherine; Lüchtenborg, Margreet; Broggio, John; Charman, Jackie; Coupland, Victoria H; Davies, Elizabeth; Jack, Ruth H; Sullivan, Richard; Vedsted, Peter; Horgan, Kieran; Pearce, Neil; Purushotham, Arnie.

I: B J C, 25.10.2016.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Møller, H, Henson, K, Lüchtenborg, M, Broggio, J, Charman, J, Coupland, VH, Davies, E, Jack, RH, Sullivan, R, Vedsted, P, Horgan, K, Pearce, N & Purushotham, A 2016, 'Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England', B J C. https://doi.org/10.1038/bjc.2016.335

APA

Møller, H., Henson, K., Lüchtenborg, M., Broggio, J., Charman, J., Coupland, V. H., Davies, E., Jack, R. H., Sullivan, R., Vedsted, P., Horgan, K., Pearce, N., & Purushotham, A. (2016). Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England. B J C. https://doi.org/10.1038/bjc.2016.335

CBE

Møller H, Henson K, Lüchtenborg M, Broggio J, Charman J, Coupland VH, Davies E, Jack RH, Sullivan R, Vedsted P, Horgan K, Pearce N, Purushotham A. 2016. Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England. B J C. https://doi.org/10.1038/bjc.2016.335

MLA

Vancouver

Author

Møller, Henrik ; Henson, Katherine ; Lüchtenborg, Margreet ; Broggio, John ; Charman, Jackie ; Coupland, Victoria H ; Davies, Elizabeth ; Jack, Ruth H ; Sullivan, Richard ; Vedsted, Peter ; Horgan, Kieran ; Pearce, Neil ; Purushotham, Arnie. / Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status : National cohort study in England. I: B J C. 2016.

Bibtex

@article{a783db3b458c4d149ef92f2f697be7ec,
title = "Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status: National cohort study in England",
abstract = "BACKGROUND: In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.METHODS: We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). The follow-up ended on 31 December 2014.RESULTS: The completeness of registration for prognostic variables was generally high (around 80% or higher), but it was low for progesterone receptor status (41%). Women with negative receptor status for each of the oestrogen, progesterone and HER2 receptors (triple-negative cancers) had an adjusted HR for death of 2.00 (95%CI 1.84-2.17). Black women had an age-adjusted HR of 1.77 (1.48-2.13) compared with White women.CONCLUSIONS: The excess mortality of Black women with breast cancer has contributions from socio-economic factors, stage distribution and tumour biology. The study illustrates the richness of detail in the national cancer registration data. This allows for analysis of cancer outcomes at a high level of resolution, and may form the basis for risk stratification.British Journal of Cancer advance online publication, 25 October 2016; doi:10.1038/bjc.2016.335 www.bjcancer.com.",
author = "Henrik M{\o}ller and Katherine Henson and Margreet L{\"u}chtenborg and John Broggio and Jackie Charman and Coupland, {Victoria H} and Elizabeth Davies and Jack, {Ruth H} and Richard Sullivan and Peter Vedsted and Kieran Horgan and Neil Pearce and Arnie Purushotham",
year = "2016",
month = oct,
day = "25",
doi = "10.1038/bjc.2016.335",
language = "English",
journal = "B J C",
issn = "0007-0920",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Short-term breast cancer survival in relation to ethnicity, stage, grade and receptor status

T2 - National cohort study in England

AU - Møller, Henrik

AU - Henson, Katherine

AU - Lüchtenborg, Margreet

AU - Broggio, John

AU - Charman, Jackie

AU - Coupland, Victoria H

AU - Davies, Elizabeth

AU - Jack, Ruth H

AU - Sullivan, Richard

AU - Vedsted, Peter

AU - Horgan, Kieran

AU - Pearce, Neil

AU - Purushotham, Arnie

PY - 2016/10/25

Y1 - 2016/10/25

N2 - BACKGROUND: In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.METHODS: We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). The follow-up ended on 31 December 2014.RESULTS: The completeness of registration for prognostic variables was generally high (around 80% or higher), but it was low for progesterone receptor status (41%). Women with negative receptor status for each of the oestrogen, progesterone and HER2 receptors (triple-negative cancers) had an adjusted HR for death of 2.00 (95%CI 1.84-2.17). Black women had an age-adjusted HR of 1.77 (1.48-2.13) compared with White women.CONCLUSIONS: The excess mortality of Black women with breast cancer has contributions from socio-economic factors, stage distribution and tumour biology. The study illustrates the richness of detail in the national cancer registration data. This allows for analysis of cancer outcomes at a high level of resolution, and may form the basis for risk stratification.British Journal of Cancer advance online publication, 25 October 2016; doi:10.1038/bjc.2016.335 www.bjcancer.com.

AB - BACKGROUND: In the re-organisation of cancer registration in England in 2012, a high priority was given to the recording of cancer stage and other prognostic clinical data items.METHODS: We extracted 86 852 breast cancer records for women resident in England and diagnosed during 2012-2013. Information on age, ethnicity, socio-economic status, comorbidity, tumour stage, grade, morphology and oestrogen, progesterone and HER2 receptor status was included. The two-year cumulative risk of death from any cause was estimated with the Kaplan-Meier method, and univariate and multivariate Cox proportional hazards regressions were used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). The follow-up ended on 31 December 2014.RESULTS: The completeness of registration for prognostic variables was generally high (around 80% or higher), but it was low for progesterone receptor status (41%). Women with negative receptor status for each of the oestrogen, progesterone and HER2 receptors (triple-negative cancers) had an adjusted HR for death of 2.00 (95%CI 1.84-2.17). Black women had an age-adjusted HR of 1.77 (1.48-2.13) compared with White women.CONCLUSIONS: The excess mortality of Black women with breast cancer has contributions from socio-economic factors, stage distribution and tumour biology. The study illustrates the richness of detail in the national cancer registration data. This allows for analysis of cancer outcomes at a high level of resolution, and may form the basis for risk stratification.British Journal of Cancer advance online publication, 25 October 2016; doi:10.1038/bjc.2016.335 www.bjcancer.com.

U2 - 10.1038/bjc.2016.335

DO - 10.1038/bjc.2016.335

M3 - Journal article

C2 - 27780193

JO - B J C

JF - B J C

SN - 0007-0920

ER -