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Peter Vedsted

Evaluating diagnostic strategies for early detection of cancer: the CanTest framework

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Evaluating diagnostic strategies for early detection of cancer : the CanTest framework. / Walter, Fiona M; Thompson, Matthew J; Wellwood, Ian et al.

I: BMC Cancer, Bind 19, Nr. 1, 586, 2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Walter, FM, Thompson, MJ, Wellwood, I, Abel, GA, Hamilton, W, Johnson, M, Lyratzopoulos, G, Messenger, MP, Neal, RD, Rubin, G, Singh, H, Spencer, A, Sutton, S, Vedsted, P & Emery, JD 2019, 'Evaluating diagnostic strategies for early detection of cancer: the CanTest framework', BMC Cancer, bind 19, nr. 1, 586. https://doi.org/10.1186/s12885-019-5746-6

APA

Walter, F. M., Thompson, M. J., Wellwood, I., Abel, G. A., Hamilton, W., Johnson, M., Lyratzopoulos, G., Messenger, M. P., Neal, R. D., Rubin, G., Singh, H., Spencer, A., Sutton, S., Vedsted, P., & Emery, J. D. (2019). Evaluating diagnostic strategies for early detection of cancer: the CanTest framework. BMC Cancer, 19(1), [586]. https://doi.org/10.1186/s12885-019-5746-6

CBE

Walter FM, Thompson MJ, Wellwood I, Abel GA, Hamilton W, Johnson M, Lyratzopoulos G, Messenger MP, Neal RD, Rubin G, et al. 2019. Evaluating diagnostic strategies for early detection of cancer: the CanTest framework. BMC Cancer. 19(1):Article 586. https://doi.org/10.1186/s12885-019-5746-6

MLA

Vancouver

Walter FM, Thompson MJ, Wellwood I, Abel GA, Hamilton W, Johnson M et al. Evaluating diagnostic strategies for early detection of cancer: the CanTest framework. BMC Cancer. 2019;19(1). 586. https://doi.org/10.1186/s12885-019-5746-6

Author

Walter, Fiona M ; Thompson, Matthew J ; Wellwood, Ian et al. / Evaluating diagnostic strategies for early detection of cancer : the CanTest framework. I: BMC Cancer. 2019 ; Bind 19, Nr. 1.

Bibtex

@article{d5dbb43edb59412787221d80ff0d804d,
title = "Evaluating diagnostic strategies for early detection of cancer: the CanTest framework",
abstract = "BACKGROUND: Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis.METHODS: We performed a systematic scoping review of frameworks for the evaluation of tests and diagnostic approaches.RESULTS: We identified 16 frameworks: none addressed the entire continuum from test development to impact on diagnosis and patient outcomes in the intended population, nor the way in which tests may be used for triage purposes as part of a wider diagnostic strategy. Informed by these findings, we developed a new framework, the 'CanTest Framework', which proposes five iterative research phases forming a clear translational pathway from new test development to health system implementation and evaluation.CONCLUSION: This framework is suitable for testing in low prevalence populations, where tests are often applied for triage testing and incorporated into a wider diagnostic strategy. It has relevance for a wide range of stakeholders including patients, policymakers, purchasers, healthcare providers and industry.",
keywords = "BIOMARKER DEVELOPMENT, CARE-RELATED TESTS, Cancer, Conceptual framework, DECISION-MAKING, Diagnosis, Diagnostic strategies, Early detection, HEALTH-CARE, Primary care, TASK-FORCE, UTILITY",
author = "Walter, {Fiona M} and Thompson, {Matthew J} and Ian Wellwood and Abel, {Gary A} and William Hamilton and Margaret Johnson and Georgios Lyratzopoulos and Messenger, {Michael P} and Neal, {Richard D} and Greg Rubin and Hardeep Singh and Anne Spencer and Stephen Sutton and Peter Vedsted and Emery, {Jon D}",
year = "2019",
doi = "10.1186/s12885-019-5746-6",
language = "English",
volume = "19",
journal = "B M C Cancer",
issn = "1471-2407",
publisher = "BioMed Central Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Evaluating diagnostic strategies for early detection of cancer

T2 - the CanTest framework

AU - Walter, Fiona M

AU - Thompson, Matthew J

AU - Wellwood, Ian

AU - Abel, Gary A

AU - Hamilton, William

AU - Johnson, Margaret

AU - Lyratzopoulos, Georgios

AU - Messenger, Michael P

AU - Neal, Richard D

AU - Rubin, Greg

AU - Singh, Hardeep

AU - Spencer, Anne

AU - Sutton, Stephen

AU - Vedsted, Peter

AU - Emery, Jon D

PY - 2019

Y1 - 2019

N2 - BACKGROUND: Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis.METHODS: We performed a systematic scoping review of frameworks for the evaluation of tests and diagnostic approaches.RESULTS: We identified 16 frameworks: none addressed the entire continuum from test development to impact on diagnosis and patient outcomes in the intended population, nor the way in which tests may be used for triage purposes as part of a wider diagnostic strategy. Informed by these findings, we developed a new framework, the 'CanTest Framework', which proposes five iterative research phases forming a clear translational pathway from new test development to health system implementation and evaluation.CONCLUSION: This framework is suitable for testing in low prevalence populations, where tests are often applied for triage testing and incorporated into a wider diagnostic strategy. It has relevance for a wide range of stakeholders including patients, policymakers, purchasers, healthcare providers and industry.

AB - BACKGROUND: Novel diagnostic triage and testing strategies to support early detection of cancer could improve clinical outcomes. Most apparently promising diagnostic tests ultimately fail because of inadequate performance in real-world, low prevalence populations such as primary care or general community populations. They should therefore be systematically evaluated before implementation to determine whether they lead to earlier detection, are cost-effective, and improve patient safety and quality of care, while minimising over-investigation and over-diagnosis.METHODS: We performed a systematic scoping review of frameworks for the evaluation of tests and diagnostic approaches.RESULTS: We identified 16 frameworks: none addressed the entire continuum from test development to impact on diagnosis and patient outcomes in the intended population, nor the way in which tests may be used for triage purposes as part of a wider diagnostic strategy. Informed by these findings, we developed a new framework, the 'CanTest Framework', which proposes five iterative research phases forming a clear translational pathway from new test development to health system implementation and evaluation.CONCLUSION: This framework is suitable for testing in low prevalence populations, where tests are often applied for triage testing and incorporated into a wider diagnostic strategy. It has relevance for a wide range of stakeholders including patients, policymakers, purchasers, healthcare providers and industry.

KW - BIOMARKER DEVELOPMENT

KW - CARE-RELATED TESTS

KW - Cancer

KW - Conceptual framework

KW - DECISION-MAKING

KW - Diagnosis

KW - Diagnostic strategies

KW - Early detection

KW - HEALTH-CARE

KW - Primary care

KW - TASK-FORCE

KW - UTILITY

UR - http://www.scopus.com/inward/record.url?scp=85067307432&partnerID=8YFLogxK

U2 - 10.1186/s12885-019-5746-6

DO - 10.1186/s12885-019-5746-6

M3 - Journal article

C2 - 31200676

VL - 19

JO - B M C Cancer

JF - B M C Cancer

SN - 1471-2407

IS - 1

M1 - 586

ER -