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Peter Sørensen

Genomic Feature Models

Publikation: KonferencebidragPaperForskningpeer review

Whole-genome sequences and multiple trait phenotypes from large numbers of individuals will soon be available in many populations. Well established statistical modeling approaches enable the genetic analyses of complex trait phenotypes while accounting for a variety of additive and non-additive genetic mechanisms. These modeling approaches have proven to be highly useful to determine population genetic parameters as well as prediction of genetic risk or value. We present a series of statistical modelling approaches that use prior biological information for evaluating the collective action of sets of genetic variants. We have applied these approaches to whole genome sequences and a complex trait phenotype resistance to starvation collected on inbred lines from the Drosophila Genome Reference Panel population. We identified a number of genomic features classification schemes (e.g. prior QTL regions and gene ontologies) that provide better model fit and increase predictive ability of the statistical model for this trait.
OriginalsprogEngelsk
Udgivelsesår18 aug. 2014
Antal sider5
StatusUdgivet - 18 aug. 2014
Begivenhed10th World Congress on Genetics Applied to Livestock Production (WCGALP) - The Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4, Vancouver, Canada
Varighed: 17 aug. 201422 aug. 2014
Konferencens nummer: 10th

Konference

Konference10th World Congress on Genetics Applied to Livestock Production (WCGALP)
Nummer10th
LokationThe Westin Bayshore, 1601 Bayshore Drive, Vancouver, BC V6G 2V4
LandCanada
ByVancouver
Periode17/08/201422/08/2014

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