Aarhus University Seal / Aarhus Universitets segl

Peter Sørensen

Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. / Gordon, Ryan A; Merrill, Michele La; Hunter, Kent W; Sørensen, Peter; Threadgill, David W; Pomp, Daniel.

I: Clinical and Experimental Metastasis, Bind 27, Nr. 5, 2010, s. 279-293.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Gordon, RA, Merrill, ML, Hunter, KW, Sørensen, P, Threadgill, DW & Pomp, D 2010, 'Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis', Clinical and Experimental Metastasis, bind 27, nr. 5, s. 279-293. https://doi.org/10.1007/s10585-010-9326-z

APA

Gordon, R. A., Merrill, M. L., Hunter, K. W., Sørensen, P., Threadgill, D. W., & Pomp, D. (2010). Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. Clinical and Experimental Metastasis, 27(5), 279-293. https://doi.org/10.1007/s10585-010-9326-z

CBE

MLA

Vancouver

Author

Gordon, Ryan A ; Merrill, Michele La ; Hunter, Kent W ; Sørensen, Peter ; Threadgill, David W ; Pomp, Daniel. / Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis. I: Clinical and Experimental Metastasis. 2010 ; Bind 27, Nr. 5. s. 279-293.

Bibtex

@article{606be510472511df8b17000ea68e967b,
title = "Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis",
abstract = "Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Among environmental factors, body composition and intake of specific dietary components like total fat are associated with increased incidence of breast cancer and metastasis. We previously showed that mice fed a high-fat diet have shorter mammary cancer latency, increased tumor growth and more pulmonary metastases than mice fed a standard diet. Subsequent genetic analysis identified several modifiers of metastatic mammary cancer along with widespread interactions between cancer modifiers and dietary fat. To elucidate diet-dependent genetic modifiers of mammary cancer and metastasis risk, global gene expression profiles and copy number alterations from mammary cancers were measured and expression quantitative trait loci (eQTL) identified. Functional candidate genes that colocalized with previously detected metastasis modifiers were identified. Additional analyses, such as eQTL by dietary fat interaction analysis, causality and database evaluations, helped to further refine the candidate loci to produce an enriched list of genes potentially involved in the pathogenesis of metastatic mammary cancer",
keywords = "Breast cancer, Causality, eQTL, High-fat diet, Tumors",
author = "Gordon, {Ryan A} and Merrill, {Michele La} and Hunter, {Kent W} and Peter S{\o}rensen and Threadgill, {David W} and Daniel Pomp",
year = "2010",
doi = "10.1007/s10585-010-9326-z",
language = "English",
volume = "27",
pages = "279--293",
journal = "Clinical and Experimental Metastasis",
issn = "0262-0898",
publisher = "Springer",
number = "5",

}

RIS

TY - JOUR

T1 - Dietary fat-dependent transcriptional architecture and copy number alterations associated with modifiers of mammary cancer metastasis

AU - Gordon, Ryan A

AU - Merrill, Michele La

AU - Hunter, Kent W

AU - Sørensen, Peter

AU - Threadgill, David W

AU - Pomp, Daniel

PY - 2010

Y1 - 2010

N2 - Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Among environmental factors, body composition and intake of specific dietary components like total fat are associated with increased incidence of breast cancer and metastasis. We previously showed that mice fed a high-fat diet have shorter mammary cancer latency, increased tumor growth and more pulmonary metastases than mice fed a standard diet. Subsequent genetic analysis identified several modifiers of metastatic mammary cancer along with widespread interactions between cancer modifiers and dietary fat. To elucidate diet-dependent genetic modifiers of mammary cancer and metastasis risk, global gene expression profiles and copy number alterations from mammary cancers were measured and expression quantitative trait loci (eQTL) identified. Functional candidate genes that colocalized with previously detected metastasis modifiers were identified. Additional analyses, such as eQTL by dietary fat interaction analysis, causality and database evaluations, helped to further refine the candidate loci to produce an enriched list of genes potentially involved in the pathogenesis of metastatic mammary cancer

AB - Breast cancer is a complex disease resulting from a combination of genetic and environmental factors. Among environmental factors, body composition and intake of specific dietary components like total fat are associated with increased incidence of breast cancer and metastasis. We previously showed that mice fed a high-fat diet have shorter mammary cancer latency, increased tumor growth and more pulmonary metastases than mice fed a standard diet. Subsequent genetic analysis identified several modifiers of metastatic mammary cancer along with widespread interactions between cancer modifiers and dietary fat. To elucidate diet-dependent genetic modifiers of mammary cancer and metastasis risk, global gene expression profiles and copy number alterations from mammary cancers were measured and expression quantitative trait loci (eQTL) identified. Functional candidate genes that colocalized with previously detected metastasis modifiers were identified. Additional analyses, such as eQTL by dietary fat interaction analysis, causality and database evaluations, helped to further refine the candidate loci to produce an enriched list of genes potentially involved in the pathogenesis of metastatic mammary cancer

KW - Breast cancer

KW - Causality

KW - eQTL

KW - High-fat diet

KW - Tumors

U2 - 10.1007/s10585-010-9326-z

DO - 10.1007/s10585-010-9326-z

M3 - Journal article

C2 - 20354763

VL - 27

SP - 279

EP - 293

JO - Clinical and Experimental Metastasis

JF - Clinical and Experimental Metastasis

SN - 0262-0898

IS - 5

ER -