Institut for Biologi

Aarhus University Seal / Aarhus Universitets segl

Peter Sørensen

Candidate Genes Detected in Transcriptome Studies are Strongly Dependent on Genetic Background

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Dokumenter

  • e 15644

    Forlagets udgivne version, 136 KB, PDF-dokument

DOI

  • Pernille Merete Sarup, Danmark
  • Jesper Givskov Sørensen
  • Torsten Nygård Kristensen, Danmark
  • Ary Anthony Hoffmann, Dept. of Genetics and Centre fpr Emvorpm,emtaæ Stress amd Adaption Research, University of Melbourne , Australien
  • Volker Loeschcke
  • Ken N Paige, Dept. of Animal Biology, School of Integrative Biology, University of Ullinois, USA
  • Peter Sørensen
Whole genome transcriptomic studies can point to potential candidate genes for organismal traits. However, the importance of potential candidates is rarely followed up through functional studies and/or by comparing results across independent studies. We have analysed the overlap of candidate genes identified from studies of gene expression in Drosophila melanogaster using similar technical platforms. We found little overlap across studies between putative candidate genes for the same traits in the same sex. Instead there was a high degree of overlap between different traits and sexes within the same genetic backgrounds. Putative candidates found using transcriptomics therefore appear very sensitive to genetic background and this can mask or override effects of treatments. The functional importance of putative candidate genes emerging from transcriptome studies needs to be validated through additional experiments and in future studies we suggest a focus on the genes, networks and pathways affecting traits in a consistent manner across backgrounds.

OriginalsprogEngelsk
TidsskriftP L o S One
Vol/bind6
Nummer1
Sider (fra-til)1-5
Antal sider5
ISSN1932-6203
DOI
StatusUdgivet - 25 jan. 2011

Se relationer på Aarhus Universitet Citationsformater

Download-statistik

Ingen data tilgængelig

ID: 4572940