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Peter Krogh Brynningsen

Association of CHA2DS2-VASc Score with Stroke, Thromboembolism, and Death in Hip Fracture Patients

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OBJECTIVES: Patients undergoing hip fracture surgery have a 10 times increased risk of stroke compared with the general population. We aimed to evaluate the association between the CHA 2DS 2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes, previous stroke/TIA [transient ischemic attack]/systemic embolism (2 points), vascular disease, age 65-74 years, and female sex) score and the risk of stroke, thromboembolism, and all-cause mortality in patients with hip fracture with or without atrial fibrillation (AF). DESIGN: Nationwide prospective cohort study. SETTING: Danish hospitals. PARTICIPANTS: Subjects were all incident hip fracture patients in Denmark age 65 years and older with surgical repair procedures between 2004 and 2016 (n = 78,096). Participants were identified using the Danish Multidisciplinary Hip Fracture Registry. MEASUREMENTS: We calculated incidence rates, cumulative incidences, and hazard ratios (HRs) with 95% confidence intervals (CIs) by CHA 2DS 2-VASc score, stratified on AF history. RESULTS: The cumulative incidence of ischemic stroke 1 year after hip fracture increased with ascending CHA 2DS 2-VASc score, and it was 1.9% for patients with a score of 1 and 8.6% for patients with a score above 5 in the AF group. Corresponding incidences in the non-AF group were 1.6% and 7.6%. Compared with a CHA 2DS 2-VASc score of 1, adjusted HRs were 5.53 (95% CI = 1.37-22.24) among AF patients and 4.91 (95% CI = 3.40-7.10) among non-AF patients with a score above 5. A dose-response–like association was observed for all cardiovascular outcomes. All-cause mortality risks and HRs were substantially higher for all CHA 2DS 2-VASc scores above 1 in both the AF group and the non-AF group. CONCLUSION: Among patients with hip fracture, a higher CHA 2DS 2-VASc score was associated with increased risk of stroke, thromboembolism, and death. This finding applied both to patients with and without AF. Patients with high CHA 2DS 2-VASc scores had almost similar absolute risks for cardiovascular outcomes, irrespective of AF.

TidsskriftJournal of the American Geriatrics Society
Sider (fra-til)1698-1705
Antal sider8
StatusUdgivet - 2020

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