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Peter Borgen Sørensen

Implementing the DF4 in a robust model, allowing for enhanced comparison, prioritisation and grouping of Nanomaterials

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Implementing the DF4 in a robust model, allowing for enhanced comparison, prioritisation and grouping of Nanomaterials. / Scott-Fordsmand, Janeck J.; Amorim, Mónica J.B.; Sørensen, Peter B.

I: Regulatory Toxicology and Pharmacology, Bind 92, 01.02.2018, s. 207-212.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Bibtex

@article{a5d3ec95e2ec49e7804f2d54e35e9fec,
title = "Implementing the DF4 in a robust model, allowing for enhanced comparison, prioritisation and grouping of Nanomaterials",
abstract = "It is here shown how partial order can be used to provide a robust and consistent implementation of the DF4 approach which provides unbiased information enabling comparison and open up the possibility for grouping. The approach is based on few assumptions, works well with the data, can include different types of input parameters, and can provide fundamental information about the ranks of tested materials. It is shown that the materials in many cases are below one threshold within a tier, but above another threshold within the same tier. It is also observed that the ranks of the materials can differ between tiers, although this is less relevant for DF4 since parameters evaluation may be hierarchical.",
keywords = "Hazard assessment-, Nanomaterials, Partial order, Ranking, Regulatory",
author = "Scott-Fordsmand, {Janeck J.} and Amorim, {M{\'o}nica J.B.} and S{\o}rensen, {Peter B.}",
year = "2018",
month = feb,
day = "1",
doi = "10.1016/j.yrtph.2017.12.008",
language = "English",
volume = "92",
pages = "207--212",
journal = "Regulatory Toxicology and Pharmacology",
issn = "0273-2300",
publisher = "Academic Press",

}

RIS

TY - JOUR

T1 - Implementing the DF4 in a robust model, allowing for enhanced comparison, prioritisation and grouping of Nanomaterials

AU - Scott-Fordsmand, Janeck J.

AU - Amorim, Mónica J.B.

AU - Sørensen, Peter B.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - It is here shown how partial order can be used to provide a robust and consistent implementation of the DF4 approach which provides unbiased information enabling comparison and open up the possibility for grouping. The approach is based on few assumptions, works well with the data, can include different types of input parameters, and can provide fundamental information about the ranks of tested materials. It is shown that the materials in many cases are below one threshold within a tier, but above another threshold within the same tier. It is also observed that the ranks of the materials can differ between tiers, although this is less relevant for DF4 since parameters evaluation may be hierarchical.

AB - It is here shown how partial order can be used to provide a robust and consistent implementation of the DF4 approach which provides unbiased information enabling comparison and open up the possibility for grouping. The approach is based on few assumptions, works well with the data, can include different types of input parameters, and can provide fundamental information about the ranks of tested materials. It is shown that the materials in many cases are below one threshold within a tier, but above another threshold within the same tier. It is also observed that the ranks of the materials can differ between tiers, although this is less relevant for DF4 since parameters evaluation may be hierarchical.

KW - Hazard assessment-

KW - Nanomaterials

KW - Partial order

KW - Ranking

KW - Regulatory

UR - http://www.scopus.com/inward/record.url?scp=85038825586&partnerID=8YFLogxK

U2 - 10.1016/j.yrtph.2017.12.008

DO - 10.1016/j.yrtph.2017.12.008

M3 - Journal article

C2 - 29253514

AN - SCOPUS:85038825586

VL - 92

SP - 207

EP - 212

JO - Regulatory Toxicology and Pharmacology

JF - Regulatory Toxicology and Pharmacology

SN - 0273-2300

ER -