Pernille Tine Jensen

Survival after a nationwide adoption of robotic minimally invasive surgery for early-stage cervical cancer – A population-based study

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Pernille T. Jensen
  • Tine H. Schnack, Rigshospitalet
  • ,
  • Ligita P. Frøding, Rigshospitalet
  • ,
  • Signe F. Bjørn, Rigshospitalet
  • ,
  • Henrik Lajer, Rigshospitalet
  • ,
  • Algirdas Markauskas, Syddansk Universitet
  • ,
  • Kirsten M. Jochumsen, Syddansk Universitet
  • ,
  • Katrine Fuglsang
  • Jacob Dinesen
  • ,
  • Charlotte H. Søgaard
  • ,
  • Erik Søgaard-Andersen, Aalborg Universitet
  • ,
  • Marianne M. Jensen, Aalborg Universitet
  • ,
  • Aage Knudsen, Aalborg Universitet
  • ,
  • Laura H. Øster, Københavns Universitet
  • ,
  • Claus Høgdall, Rigshospitalet

Aim: Lately, the safety of minimally invasive surgery (MIS) in the treatment of cervical cancer (CC) has been questioned. This study aimed to evaluate the risk of recurrence and survival after a nationwide adoption of robotic MIS for the treatment of early-stage CC in Denmark. Methods: Population-based data on all Danish women with early-stage CC, who underwent radical hysterectomy January 1st 2005–June 30th 2017 were retrieved from the Danish Gynecologic Cancer Database and enriched with follow-up data on recurrence, death and cause of death. The cohort was divided into two groups according to the year of robotic MIS introduction at each cancer centre. Chi-squared or Fischer test, the Kaplan Meier method and multivariate Cox regression were used for comparison between groups. Results: One thousand one hundred twenty-five patients with CC were included; 530 underwent surgery before (group 1) and 595 underwent surgery after (group 2) the introduction of robotic MIS. The 5-year rate of recurrence was low: 8.2% and 6.3% (p = 0.55) in group 1 and 2, respectively. In adjusted analyses, this corresponded to a five-year disease-free survival, hazard ratio (HR) 1.23 [95% confidence interval (CI) 0.79-1.93]. No difference in site of recurrence (P = 0.19) was observed. The cumulative cancer-specific survival was 94.1% and 95.9% (P = 0.10) in group 1 and 2, respectively, corresponding to a HR 0.60 [95% CI 0.32–1.11] in adjusted analyses. Conclusion: In this population-based cohort study, the Danish nationwide adoption of robotic MIS for early-stage CC was not associated with increased risk of recurrence or reduction in survival outcomes.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Cancer
Vol/bind128
Sider (fra-til)47-56
Antal sider10
ISSN0959-8049
DOI
StatusUdgivet - 2020

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