Pernille Tine Jensen

Sentinel lymph node mapping for endometrial and cervical cancer in Denmark

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Sentinel lymph node mapping for endometrial and cervical cancer in Denmark. / Bjørnholt, Sarah Marie; Sponholtz, Sara Elizabeth; Markauskas, Algirdas et al.

I: Danish Medical Journal, Bind 68, Nr. 4, A11200886, 2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

APA

CBE

Bjørnholt SM, Sponholtz SE, Markauskas A, Froeding LP, Larsen CR, Fuglsang K, Schledermann D, Mogensen O, Jensen PT. 2021. Sentinel lymph node mapping for endometrial and cervical cancer in Denmark. Danish Medical Journal. 68(4):Article A11200886.

MLA

Vancouver

Bjørnholt SM, Sponholtz SE, Markauskas A, Froeding LP, Larsen CR, Fuglsang K et al. Sentinel lymph node mapping for endometrial and cervical cancer in Denmark. Danish Medical Journal. 2021;68(4). A11200886.

Author

Bjørnholt, Sarah Marie ; Sponholtz, Sara Elizabeth ; Markauskas, Algirdas et al. / Sentinel lymph node mapping for endometrial and cervical cancer in Denmark. I: Danish Medical Journal. 2021 ; Bind 68, Nr. 4.

Bibtex

@article{ce4199da7e624d7fb7e3695233e9eafe,
title = "Sentinel lymph node mapping for endometrial and cervical cancer in Denmark",
abstract = "INTRODUCTION: This was a surgical pilot study to systematically introduce the technique of sentinel lymph node (SLN) mapping in women with early-stage stage cervical cancer (CC) and endometrial cancer (EC) in Denmark. The study aimed to facilitate structured surgical training to ensure surgeon proficiency in SLN mapping. The study precedes two national prospective studies on the oncological safety and correct patient selection for SLN mapping in CC and EC. METHODS: The study was conducted at four gynaecological cancer centres at Odense and Aarhus University Hospital, Rigshospitalet and Herlev Hospital, between September 2016 and August 2019. All centres went through a protocolled introduction to the surgical technique, pelvic lymphatic drainage, pathological ultra-staging and data entry. A criterion of a total (uni- and bilateral) SLN detection of > 80%, based on 30 SLN mappings was set. RESULTS: The four centres performed 140 (range: 30-46) procedures. The total SLN detection rate was 91.3% with bilateral SLN detection in 68.8% and unilateral SLN detection in 22.5% of cases. The cumulated total SLN detection rate at three centres was above the pre-set 80% criterion from the beginning of inclusion, whereas one centre reached the criterion after 20 procedures. CONCLUSIONS: In this study, all centres demonstrated international-level SLN detection rates within 30 procedures. Hence, all centres met the study criterion regarding surgeon proficiency and were eligible for the national studies. Funding: Eva & Henry Fr{\ae}nkels Fond, Frimodt-Heineke Fonden, Kong Christian X Fond. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (R. no.15/52037). The SENTIREC studies including this pilot study are registered with clinicaltrials.gov (NCT02825355 and NCT02820506). ",
author = "Bj{\o}rnholt, {Sarah Marie} and Sponholtz, {Sara Elizabeth} and Algirdas Markauskas and Froeding, {Ligita Paskeviciute} and Larsen, {Christian Rifbjerg} and Katrine Fuglsang and Doris Schledermann and Ole Mogensen and Jensen, {Pernille Tine}",
year = "2021",
language = "English",
volume = "68",
journal = "Danish Medical Journal",
issn = "2245-1919",
publisher = "Den Almindelige Danske L{\ae}geforening",
number = "4",

}

RIS

TY - JOUR

T1 - Sentinel lymph node mapping for endometrial and cervical cancer in Denmark

AU - Bjørnholt, Sarah Marie

AU - Sponholtz, Sara Elizabeth

AU - Markauskas, Algirdas

AU - Froeding, Ligita Paskeviciute

AU - Larsen, Christian Rifbjerg

AU - Fuglsang, Katrine

AU - Schledermann, Doris

AU - Mogensen, Ole

AU - Jensen, Pernille Tine

PY - 2021

Y1 - 2021

N2 - INTRODUCTION: This was a surgical pilot study to systematically introduce the technique of sentinel lymph node (SLN) mapping in women with early-stage stage cervical cancer (CC) and endometrial cancer (EC) in Denmark. The study aimed to facilitate structured surgical training to ensure surgeon proficiency in SLN mapping. The study precedes two national prospective studies on the oncological safety and correct patient selection for SLN mapping in CC and EC. METHODS: The study was conducted at four gynaecological cancer centres at Odense and Aarhus University Hospital, Rigshospitalet and Herlev Hospital, between September 2016 and August 2019. All centres went through a protocolled introduction to the surgical technique, pelvic lymphatic drainage, pathological ultra-staging and data entry. A criterion of a total (uni- and bilateral) SLN detection of > 80%, based on 30 SLN mappings was set. RESULTS: The four centres performed 140 (range: 30-46) procedures. The total SLN detection rate was 91.3% with bilateral SLN detection in 68.8% and unilateral SLN detection in 22.5% of cases. The cumulated total SLN detection rate at three centres was above the pre-set 80% criterion from the beginning of inclusion, whereas one centre reached the criterion after 20 procedures. CONCLUSIONS: In this study, all centres demonstrated international-level SLN detection rates within 30 procedures. Hence, all centres met the study criterion regarding surgeon proficiency and were eligible for the national studies. Funding: Eva & Henry Frænkels Fond, Frimodt-Heineke Fonden, Kong Christian X Fond. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (R. no.15/52037). The SENTIREC studies including this pilot study are registered with clinicaltrials.gov (NCT02825355 and NCT02820506).

AB - INTRODUCTION: This was a surgical pilot study to systematically introduce the technique of sentinel lymph node (SLN) mapping in women with early-stage stage cervical cancer (CC) and endometrial cancer (EC) in Denmark. The study aimed to facilitate structured surgical training to ensure surgeon proficiency in SLN mapping. The study precedes two national prospective studies on the oncological safety and correct patient selection for SLN mapping in CC and EC. METHODS: The study was conducted at four gynaecological cancer centres at Odense and Aarhus University Hospital, Rigshospitalet and Herlev Hospital, between September 2016 and August 2019. All centres went through a protocolled introduction to the surgical technique, pelvic lymphatic drainage, pathological ultra-staging and data entry. A criterion of a total (uni- and bilateral) SLN detection of > 80%, based on 30 SLN mappings was set. RESULTS: The four centres performed 140 (range: 30-46) procedures. The total SLN detection rate was 91.3% with bilateral SLN detection in 68.8% and unilateral SLN detection in 22.5% of cases. The cumulated total SLN detection rate at three centres was above the pre-set 80% criterion from the beginning of inclusion, whereas one centre reached the criterion after 20 procedures. CONCLUSIONS: In this study, all centres demonstrated international-level SLN detection rates within 30 procedures. Hence, all centres met the study criterion regarding surgeon proficiency and were eligible for the national studies. Funding: Eva & Henry Frænkels Fond, Frimodt-Heineke Fonden, Kong Christian X Fond. TRIAL REGISTRATION: The study was approved by the Danish Data Protection Agency (R. no.15/52037). The SENTIREC studies including this pilot study are registered with clinicaltrials.gov (NCT02825355 and NCT02820506).

M3 - Journal article

C2 - 33829991

VL - 68

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 4

M1 - A11200886

ER -