Pernille Tine Jensen

TY - JOUR

T1 - Quantitative sensory examination of epidural anaesthesia and analgesia in man; dose-response effect of bupivacaine

AU - Brennum, J

AU - Jensen, Pernille Tine

AU - Horn, A

AU - Arendt-Nielsen, L

AU - Secher, N H

PY - 1994/3

Y1 - 1994/3

N2 - Time and dose-response functions of 4 concentrations of epidural bupivacaine (0.075, 0.125, 0.25, and 0.5%; 20 ml) on somatosensory and motor functions were examined in 10 healthy volunteers. Every hour for 8 h the effect of epidural bupivacaine on perception of painful and non-painful stimuli was quantified with 12 psychophysical measures. In addition knee extension strength, reaction time and skin temperature were examined. The two lowest concentrations of bupivacaine induced hypoalgesia without impairment of motor function. Epidural bupivacaine produced differential blockade of non-painful somatosensory functions in the following order: warmth perception > cold perception > perception of electrical stimuli. Epidural bupivacaine induced more pronounced hypoalgesia for short-lasting than for prolonged stimuli. A modality-related blocking order was observed for prolonged painful stimuli: heat > mechanical > electrical. It is suggested that differential blockade of somatosensory functions is caused by differences both in conduction blockade of nerve fibres and in central integration of afferent nerve impulses.

AB - Time and dose-response functions of 4 concentrations of epidural bupivacaine (0.075, 0.125, 0.25, and 0.5%; 20 ml) on somatosensory and motor functions were examined in 10 healthy volunteers. Every hour for 8 h the effect of epidural bupivacaine on perception of painful and non-painful stimuli was quantified with 12 psychophysical measures. In addition knee extension strength, reaction time and skin temperature were examined. The two lowest concentrations of bupivacaine induced hypoalgesia without impairment of motor function. Epidural bupivacaine produced differential blockade of non-painful somatosensory functions in the following order: warmth perception > cold perception > perception of electrical stimuli. Epidural bupivacaine induced more pronounced hypoalgesia for short-lasting than for prolonged stimuli. A modality-related blocking order was observed for prolonged painful stimuli: heat > mechanical > electrical. It is suggested that differential blockade of somatosensory functions is caused by differences both in conduction blockade of nerve fibres and in central integration of afferent nerve impulses.

KW - Adult

KW - Analgesia, Epidural

KW - Anesthesia, Epidural

KW - Bupivacaine/administration & dosage

KW - Dose-Response Relationship, Drug

KW - Double-Blind Method

KW - Electric Stimulation

KW - Female

KW - Hot Temperature

KW - Humans

KW - Isometric Contraction/drug effects

KW - Lasers

KW - Male

KW - Pain/drug therapy

KW - Pain Threshold/drug effects

KW - Physical Stimulation

KW - Psychomotor Performance/drug effects

KW - Reaction Time/drug effects

KW - Skin Temperature/drug effects

U2 - 10.1016/0304-3959(94)90170-8

DO - 10.1016/0304-3959(94)90170-8

M3 - Journal article

C2 - 8022625

VL - 56

SP - 315

EP - 326

JO - Pain

JF - Pain

SN - 0304-3959

IS - 3

ER -