Pernille Tine Jensen

Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. / Sandvik, Rikke Mulvad; Jensen, Pernille Tine; Hendel, Helle W; Palle, Connie.

I: Danish medical bulletin, Bind 58, Nr. 3, 03.2011, s. A4240.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Sandvik, RM, Jensen, PT, Hendel, HW & Palle, C 2011, 'Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer', Danish medical bulletin, bind 58, nr. 3, s. A4240.

APA

Sandvik, R. M., Jensen, P. T., Hendel, H. W., & Palle, C. (2011). Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. Danish medical bulletin, 58(3), A4240.

CBE

Sandvik RM, Jensen PT, Hendel HW, Palle C. 2011. Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. Danish medical bulletin. 58(3):A4240.

MLA

Sandvik, Rikke Mulvad o.a.. "Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer". Danish medical bulletin. 2011, 58(3). A4240.

Vancouver

Sandvik RM, Jensen PT, Hendel HW, Palle C. Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. Danish medical bulletin. 2011 mar;58(3):A4240.

Author

Sandvik, Rikke Mulvad ; Jensen, Pernille Tine ; Hendel, Helle W ; Palle, Connie. / Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer. I: Danish medical bulletin. 2011 ; Bind 58, Nr. 3. s. A4240.

Bibtex

@article{6aa0bbbd9e3b49d788d1bfaa549e19eb,
title = "Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer",
abstract = "INTRODUCTION: Many studies have found that positron emission tomography-computed tomography (PET-CT) has a high sensitivity and specificity in the identification of metastasis in cervical cancer. Herlev Hospital, Denmark, has been performing PET-CTs in stage I-IV cervical cancer since 1 May 2006. The present study investigates the positive (PPV) and negative predictive value (NPV) of PET-CT in stage I disease and the clinical impact of the scan results in all disease stages.MATERIAL AND METHODS: In this retrospective study, 83 consecutive patients with cervical cancer were included between 1 May 2006 and 1 November 2007. Data were collected from patient records and PET-CT reports.RESULTS: Among 47 stage I patients, four had PET-positive findings on the scan in addition to cervical cancer. Only one was a true positive finding. Pelvic lymphadenectomy was performed in 36 stage Ia2-Ib1 patients. Histology from stage I patients revealed a PPV of 25% and a NPV of 88%. Among a total of 36 stage II-IV patients, 14 had PET-positive findings. Five patients had a biopsy performed. Three of these patients were true positives and two were true negatives. Taking of biopsies in the remaining patients was clinically irrelevant. Five patients (6%), all in stage ≥ IIb, were offered an alternative treatment owing to the additional information obtained from the PET-CT.CONCLUSION: PET-CT is useful in the identification of metastatic disease in cervical cancer and it may assist optimal treatment planning; especially in International Federation of Gynecologists & Obstetricians (FIGO) stage > I cancers. Histological verification of PET-positive findings is necessary. The clinical value of PET-CT in early stage cervical cancer may be questioned.",
keywords = "Adult, Aged, Aged, 80 and over, False Positive Reactions, Female, Humans, Middle Aged, Neoplasm Metastasis/diagnostic imaging, Neoplasm Staging/methods, Positron-Emission Tomography, Predictive Value of Tests, Retrospective Studies, Uterine Cervical Neoplasms/diagnostic imaging",
author = "Sandvik, {Rikke Mulvad} and Jensen, {Pernille Tine} and Hendel, {Helle W} and Connie Palle",
year = "2011",
month = mar,
language = "English",
volume = "58",
pages = "A4240",
journal = "Danish Medical Journal",
issn = "2245-1919",
publisher = "Den Almindelige Danske L{\ae}geforening",
number = "3",

}

RIS

TY - JOUR

T1 - Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer

AU - Sandvik, Rikke Mulvad

AU - Jensen, Pernille Tine

AU - Hendel, Helle W

AU - Palle, Connie

PY - 2011/3

Y1 - 2011/3

N2 - INTRODUCTION: Many studies have found that positron emission tomography-computed tomography (PET-CT) has a high sensitivity and specificity in the identification of metastasis in cervical cancer. Herlev Hospital, Denmark, has been performing PET-CTs in stage I-IV cervical cancer since 1 May 2006. The present study investigates the positive (PPV) and negative predictive value (NPV) of PET-CT in stage I disease and the clinical impact of the scan results in all disease stages.MATERIAL AND METHODS: In this retrospective study, 83 consecutive patients with cervical cancer were included between 1 May 2006 and 1 November 2007. Data were collected from patient records and PET-CT reports.RESULTS: Among 47 stage I patients, four had PET-positive findings on the scan in addition to cervical cancer. Only one was a true positive finding. Pelvic lymphadenectomy was performed in 36 stage Ia2-Ib1 patients. Histology from stage I patients revealed a PPV of 25% and a NPV of 88%. Among a total of 36 stage II-IV patients, 14 had PET-positive findings. Five patients had a biopsy performed. Three of these patients were true positives and two were true negatives. Taking of biopsies in the remaining patients was clinically irrelevant. Five patients (6%), all in stage ≥ IIb, were offered an alternative treatment owing to the additional information obtained from the PET-CT.CONCLUSION: PET-CT is useful in the identification of metastatic disease in cervical cancer and it may assist optimal treatment planning; especially in International Federation of Gynecologists & Obstetricians (FIGO) stage > I cancers. Histological verification of PET-positive findings is necessary. The clinical value of PET-CT in early stage cervical cancer may be questioned.

AB - INTRODUCTION: Many studies have found that positron emission tomography-computed tomography (PET-CT) has a high sensitivity and specificity in the identification of metastasis in cervical cancer. Herlev Hospital, Denmark, has been performing PET-CTs in stage I-IV cervical cancer since 1 May 2006. The present study investigates the positive (PPV) and negative predictive value (NPV) of PET-CT in stage I disease and the clinical impact of the scan results in all disease stages.MATERIAL AND METHODS: In this retrospective study, 83 consecutive patients with cervical cancer were included between 1 May 2006 and 1 November 2007. Data were collected from patient records and PET-CT reports.RESULTS: Among 47 stage I patients, four had PET-positive findings on the scan in addition to cervical cancer. Only one was a true positive finding. Pelvic lymphadenectomy was performed in 36 stage Ia2-Ib1 patients. Histology from stage I patients revealed a PPV of 25% and a NPV of 88%. Among a total of 36 stage II-IV patients, 14 had PET-positive findings. Five patients had a biopsy performed. Three of these patients were true positives and two were true negatives. Taking of biopsies in the remaining patients was clinically irrelevant. Five patients (6%), all in stage ≥ IIb, were offered an alternative treatment owing to the additional information obtained from the PET-CT.CONCLUSION: PET-CT is useful in the identification of metastatic disease in cervical cancer and it may assist optimal treatment planning; especially in International Federation of Gynecologists & Obstetricians (FIGO) stage > I cancers. Histological verification of PET-positive findings is necessary. The clinical value of PET-CT in early stage cervical cancer may be questioned.

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - False Positive Reactions

KW - Female

KW - Humans

KW - Middle Aged

KW - Neoplasm Metastasis/diagnostic imaging

KW - Neoplasm Staging/methods

KW - Positron-Emission Tomography

KW - Predictive Value of Tests

KW - Retrospective Studies

KW - Uterine Cervical Neoplasms/diagnostic imaging

M3 - Journal article

C2 - 21371401

VL - 58

SP - A4240

JO - Danish Medical Journal

JF - Danish Medical Journal

SN - 2245-1919

IS - 3

ER -