Aarhus Universitets segl

Pernille Tine Jensen

Positron emission tomography-computed tomography has a clinical impact for patients with cervical cancer

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  • Rikke Mulvad Sandvik, Department of Surgery, Glostrup Hospital. rikke_mulvad@hotmail.com
  • ,
  • Pernille Tine Jensen
  • Helle W Hendel
  • ,
  • Connie Palle

INTRODUCTION: Many studies have found that positron emission tomography-computed tomography (PET-CT) has a high sensitivity and specificity in the identification of metastasis in cervical cancer. Herlev Hospital, Denmark, has been performing PET-CTs in stage I-IV cervical cancer since 1 May 2006. The present study investigates the positive (PPV) and negative predictive value (NPV) of PET-CT in stage I disease and the clinical impact of the scan results in all disease stages.

MATERIAL AND METHODS: In this retrospective study, 83 consecutive patients with cervical cancer were included between 1 May 2006 and 1 November 2007. Data were collected from patient records and PET-CT reports.

RESULTS: Among 47 stage I patients, four had PET-positive findings on the scan in addition to cervical cancer. Only one was a true positive finding. Pelvic lymphadenectomy was performed in 36 stage Ia2-Ib1 patients. Histology from stage I patients revealed a PPV of 25% and a NPV of 88%. Among a total of 36 stage II-IV patients, 14 had PET-positive findings. Five patients had a biopsy performed. Three of these patients were true positives and two were true negatives. Taking of biopsies in the remaining patients was clinically irrelevant. Five patients (6%), all in stage ≥ IIb, were offered an alternative treatment owing to the additional information obtained from the PET-CT.

CONCLUSION: PET-CT is useful in the identification of metastatic disease in cervical cancer and it may assist optimal treatment planning; especially in International Federation of Gynecologists & Obstetricians (FIGO) stage > I cancers. Histological verification of PET-positive findings is necessary. The clinical value of PET-CT in early stage cervical cancer may be questioned.

TidsskriftDanish medical bulletin
Sider (fra-til)A4240
StatusUdgivet - mar. 2011

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