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Pernille Tine Jensen

From FIGO-2009 to FIGO-2018 in women with early-stage cervical cancer; Does the revised staging reflect risk groups?

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Sara Elisabeth Sponholtz, Odense University Hospital, Odense, Denmark.
  • ,
  • Ole Mogensen
  • Malene Grubbe Hildebrandt, Odense Univ Hosp, Odense University Hospital, Steno Diabet Ctr Odense
  • ,
  • Doris Schledermann, Odense Univ Hosp, Odense University Hospital, Steno Diabet Ctr Odense
  • ,
  • Erik Parner
  • Algirdas Markauskas, Odense University Hospital, Odense, Denmark.
  • ,
  • Ligita Paskeviciute Frøding, 1Copenhagen University Hospital, Copenhagen, Denmark. 2Aarhus University Hospital, Aarhus, Denmark. 3University of Copenhagen, Copenhagen, Denmark. 4Odense University Hospital, Odense, Denmark.
  • ,
  • Katrine Fuglsang
  • Jorun Holm, Odense University Hospital, Odense, Denmark.
  • ,
  • Sarah Marie Bjørnholt
  • Pernille Tine Jensen

OBJECTIVES: We aimed to evaluate if the revised staging according to FIGO-2018 in early-stage cervical cancer correctly predicts the risk for nodal metastases.

METHODS: We reallocated 245 women with early-stage cervical cancer from FIGO-2009 to FIGO-2018 stages using data from a national, prospective cohort study on sentinel lymph node (SLN) mapping. We used univariate and multivariate binary regression models to investigate the association between FIGO-2018 stages, tumor characteristics, and nodal metastases.

RESULTS: Stage migration occurred in 54.7% (134/245) (95% CI 48.2-61.0), due to tumor size or depth of invasion (71.6%, 96/134) and nodal metastases (28.4%, 38/134). Imaging preoperatively upstaged 7.3% (18/245); seven had nodal metastatic disease on final pathology. Upstaging occurred in 49.8% (122/245) (95% CI 43.4-56.2%) and downstaging to FIGO-2018 IA stages in 4.9% (12/245) (95% CI 2.6-8.4). The tumor size ranged from 3.0-19.0 mm in women with FIGO-2018 IA tumor characteristics, and none of the 14 women had nodal metastases. In multivariate analysis, risk factors significantly associated with nodal metastases were FIGO-2018 ≥ IB2 (RR 5.01, 95% CI 2.30-10.93, p < 0.001), proportionate depth of invasion >2/3 (RR 1.88, 95% CI 1.05-3.35, p = 0.033), and lymphovascular space invasion (RR 5.56, 95% CI 2.92-10.62, p < 0.001).

CONCLUSIONS: The FIGO-2018 revised staging system causes stage migration for a large proportion of women with early-stage cervical cancer. Women who were downstaged to FIGO-2018 IA stages did not have nodal metastatic disease. The attention on depth of invasion rather than horizontal dimension seems to correctly reflect the risk of nodal metastases.

OriginalsprogEngelsk
TidsskriftGynecologic Oncology
Vol/bind163
Nummer2
Sider (fra-til)281-288
Antal sider8
ISSN0090-8258
DOI
StatusUdgivet - nov. 2021

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Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved.

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