Per Hove Thomsen

Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS. / Melin, Karin; Skarphedinsson, Gudmundur; Thomsen, Per Hove; Weidle, Bernhard; Torp, Nor Christian; Valderhaug, Robert; Højgaard, Davíð R M A; Hybel, Katja A; Nissen, Judith Becker; Jensen, Sanne; Dahl, Kitty; Skärsäter, Ingela; Haugland, Bente Storm; Ivarsson, Tord.

I: Journal of the American Academy of Child and Adolescent Psychiatry, Bind 59, Nr. 2, 2020, s. 244-253.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Melin, K, Skarphedinsson, G, Thomsen, PH, Weidle, B, Torp, NC, Valderhaug, R, Højgaard, DRMA, Hybel, KA, Nissen, JB, Jensen, S, Dahl, K, Skärsäter, I, Haugland, BS & Ivarsson, T 2020, 'Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS', Journal of the American Academy of Child and Adolescent Psychiatry, bind 59, nr. 2, s. 244-253. https://doi.org/10.1016/j.jaac.2019.01.010

APA

Melin, K., Skarphedinsson, G., Thomsen, P. H., Weidle, B., Torp, N. C., Valderhaug, R., Højgaard, D. R. M. A., Hybel, K. A., Nissen, J. B., Jensen, S., Dahl, K., Skärsäter, I., Haugland, B. S., & Ivarsson, T. (2020). Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS. Journal of the American Academy of Child and Adolescent Psychiatry, 59(2), 244-253. https://doi.org/10.1016/j.jaac.2019.01.010

CBE

Melin K, Skarphedinsson G, Thomsen PH, Weidle B, Torp NC, Valderhaug R, Højgaard DRMA, Hybel KA, Nissen JB, Jensen S, Dahl K, Skärsäter I, Haugland BS, Ivarsson T. 2020. Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS. Journal of the American Academy of Child and Adolescent Psychiatry. 59(2):244-253. https://doi.org/10.1016/j.jaac.2019.01.010

MLA

Melin, Karin o.a.. "Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS". Journal of the American Academy of Child and Adolescent Psychiatry. 2020, 59(2). 244-253. https://doi.org/10.1016/j.jaac.2019.01.010

Vancouver

Melin K, Skarphedinsson G, Thomsen PH, Weidle B, Torp NC, Valderhaug R o.a. Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS. Journal of the American Academy of Child and Adolescent Psychiatry. 2020;59(2):244-253. https://doi.org/10.1016/j.jaac.2019.01.010

Author

Melin, Karin ; Skarphedinsson, Gudmundur ; Thomsen, Per Hove ; Weidle, Bernhard ; Torp, Nor Christian ; Valderhaug, Robert ; Højgaard, Davíð R M A ; Hybel, Katja A ; Nissen, Judith Becker ; Jensen, Sanne ; Dahl, Kitty ; Skärsäter, Ingela ; Haugland, Bente Storm ; Ivarsson, Tord. / Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS. I: Journal of the American Academy of Child and Adolescent Psychiatry. 2020 ; Bind 59, Nr. 2. s. 244-253.

Bibtex

@article{8dea5f7f3a9c43dc91e7c62af5737af9,
title = "Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS",
abstract = "OBJECTIVE: This study evaluates the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigates whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of three-year outcomes.METHOD: This study is a part of the Nordic Long-term OCD Treatment study (NordLOTS), in which 269 children and adolescents were treated with CBT. Non-responders to CBT were randomized to an extended treatment with continued CBT or pharmacotherapy with sertraline. Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores of ≤15 and ≤10 were defined as treatment response and remission, respectively. Participants were assessed two and three years after first-step CBT. Linear mixed-effects (LME) models were used to analyze the outcomes.RESULTS: Intent-to-treat analyses showed a significant reduction in the CY-BOCS total score from baseline (24.6) to the three-year follow-up (5.0) (p=.001), with a mean reduction of 5.9 from posttreatment to the three-year follow-up. Three years after treatment, 90% (n=242) of the participants were rated as responders and 73% were in clinical remission. The duration of treatment did not influence the symptom level at the three-year follow-up (p=.998) and no significant difference was found (p=.169) between the extended treatment conditions.CONCLUSION: The results suggest that evidence-based treatment for pediatric OCD has long-term positive effects, whether a first step of manualized CBT or extended treatment with CBT or sertraline. The improvements were maintained, and the symptoms decreased further during follow-up and were, after three years, similarly independent of the treatment duration and form of extended treatment.",
keywords = "cognitive-behavioral therapy, follow-up, obsessive-compulsive disorder, pediatric, sertraline",
author = "Karin Melin and Gudmundur Skarphedinsson and Thomsen, {Per Hove} and Bernhard Weidle and Torp, {Nor Christian} and Robert Valderhaug and H{\o}jgaard, {Dav{\'i}{\dh} R M A} and Hybel, {Katja A} and Nissen, {Judith Becker} and Sanne Jensen and Kitty Dahl and Ingela Sk{\"a}rs{\"a}ter and Haugland, {Bente Storm} and Tord Ivarsson",
note = "Copyright {\textcopyright} 2019 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.",
year = "2020",
doi = "10.1016/j.jaac.2019.01.010",
language = "English",
volume = "59",
pages = "244--253",
journal = "American Academy of Child and Adolescent Psychiatry. Journal",
issn = "0890-8567",
publisher = "Elsevier BV",
number = "2",

}

RIS

TY - JOUR

T1 - Treatment Gains Are Sustainable in Pediatric Obsessive-Compulsive Disorder: Three-Year Follow-Up From the NordLOTS

AU - Melin, Karin

AU - Skarphedinsson, Gudmundur

AU - Thomsen, Per Hove

AU - Weidle, Bernhard

AU - Torp, Nor Christian

AU - Valderhaug, Robert

AU - Højgaard, Davíð R M A

AU - Hybel, Katja A

AU - Nissen, Judith Becker

AU - Jensen, Sanne

AU - Dahl, Kitty

AU - Skärsäter, Ingela

AU - Haugland, Bente Storm

AU - Ivarsson, Tord

N1 - Copyright © 2019 American Academy of Child and Adolescent Psychiatry. Published by Elsevier Inc. All rights reserved.

PY - 2020

Y1 - 2020

N2 - OBJECTIVE: This study evaluates the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigates whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of three-year outcomes.METHOD: This study is a part of the Nordic Long-term OCD Treatment study (NordLOTS), in which 269 children and adolescents were treated with CBT. Non-responders to CBT were randomized to an extended treatment with continued CBT or pharmacotherapy with sertraline. Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores of ≤15 and ≤10 were defined as treatment response and remission, respectively. Participants were assessed two and three years after first-step CBT. Linear mixed-effects (LME) models were used to analyze the outcomes.RESULTS: Intent-to-treat analyses showed a significant reduction in the CY-BOCS total score from baseline (24.6) to the three-year follow-up (5.0) (p=.001), with a mean reduction of 5.9 from posttreatment to the three-year follow-up. Three years after treatment, 90% (n=242) of the participants were rated as responders and 73% were in clinical remission. The duration of treatment did not influence the symptom level at the three-year follow-up (p=.998) and no significant difference was found (p=.169) between the extended treatment conditions.CONCLUSION: The results suggest that evidence-based treatment for pediatric OCD has long-term positive effects, whether a first step of manualized CBT or extended treatment with CBT or sertraline. The improvements were maintained, and the symptoms decreased further during follow-up and were, after three years, similarly independent of the treatment duration and form of extended treatment.

AB - OBJECTIVE: This study evaluates the long-term outcomes of a stepped care treatment for pediatric obsessive-compulsive disorder (OCD) and investigates whether response to first-step cognitive-behavioral therapy (CBT) is an important indicator of three-year outcomes.METHOD: This study is a part of the Nordic Long-term OCD Treatment study (NordLOTS), in which 269 children and adolescents were treated with CBT. Non-responders to CBT were randomized to an extended treatment with continued CBT or pharmacotherapy with sertraline. Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS) scores of ≤15 and ≤10 were defined as treatment response and remission, respectively. Participants were assessed two and three years after first-step CBT. Linear mixed-effects (LME) models were used to analyze the outcomes.RESULTS: Intent-to-treat analyses showed a significant reduction in the CY-BOCS total score from baseline (24.6) to the three-year follow-up (5.0) (p=.001), with a mean reduction of 5.9 from posttreatment to the three-year follow-up. Three years after treatment, 90% (n=242) of the participants were rated as responders and 73% were in clinical remission. The duration of treatment did not influence the symptom level at the three-year follow-up (p=.998) and no significant difference was found (p=.169) between the extended treatment conditions.CONCLUSION: The results suggest that evidence-based treatment for pediatric OCD has long-term positive effects, whether a first step of manualized CBT or extended treatment with CBT or sertraline. The improvements were maintained, and the symptoms decreased further during follow-up and were, after three years, similarly independent of the treatment duration and form of extended treatment.

KW - cognitive-behavioral therapy

KW - follow-up

KW - obsessive-compulsive disorder

KW - pediatric

KW - sertraline

U2 - 10.1016/j.jaac.2019.01.010

DO - 10.1016/j.jaac.2019.01.010

M3 - Journal article

C2 - 30768383

VL - 59

SP - 244

EP - 253

JO - American Academy of Child and Adolescent Psychiatry. Journal

JF - American Academy of Child and Adolescent Psychiatry. Journal

SN - 0890-8567

IS - 2

ER -