Per Hove Thomsen

Tics Moderate Sertraline, but Not Cognitive-Behavior Therapy Response in Pediatric Obsessive-Compulsive Disorder Patients Who Do Not Respond to Cognitive-Behavior Therapy

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Gudmundur Skarphedinsson, Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway, Norge
  • Scott Compton, Duke University Medical Center, Durham, NC, USA., USA
  • Per Hove Thomsen
  • Bernhard Weidle, Norwegian University of Science and Technology, Faculty of Medicine, Regional Center for Child and Youth Mental Health and Child Welfare, Trondheim, Norway, Norge
  • Kitty Dahl, Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway, Norge
  • Judith Becker Nissen
  • Nor Christian Torp, Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway, Norge
  • Katja Hybel
  • Karin Holmgren Melin, OCD-Clinic, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden, Sverige
  • Robert Valderhaug, Norwegian University of Science and Technology, Faculty of Medicine, Regional Center for Child and Youth Mental Health and Child Welfare, Trondheim, Norway, Norge
  • Tore Wentzel-Larsen, Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway, Norge
  • Tord Ivarsson, Center for Child and Adolescent Mental Health, Eastern and Southern Norway, Oslo, Norway, Norge

OBJECTIVE: The purpose of this study was to investigate whether the presence of tic disorder is negatively associated with sertraline (SRT) outcomes, but not with continued cognitive-behavioral therapy (CBT), in a sample of youth who were unresponsive to an initial full course of CBT.

METHODS: In the Nordic Long-Term OCD Study, children and adolescents with OCD who were rated as nonresponders to 14 weeks of open-label CBT were randomized to continued CBT (n=28) or SRT treatment (n=22) for an additional 16 weeks of treatment. We investigated whether the presence or absence of comorbid tic disorder moderated treatment outcomes on the Children's Yale-Brown Obsessive Compulsive Scale (CY-BOCS).

RESULTS: Twelve out of 50 (24.0%) participants were diagnosed with comorbid tic disorder, with 7 receiving continued CBT and 5 receiving SRT, respectively. In patients without tic disorder, results showed no significant between-group differences on average CY-BOCS scores. However, in patients with comorbid tic disorder, those who received SRT had significantly lower average CY-BOCS scores than those who received continued CBT.

CONCLUSIONS: Children and adolescents with OCD and comorbid tic disorder, who are nonresponders to an initial 14 week course of CBT, may benefit more from a serotonin reuptake inhibitor (SRI) than from continued CBT.

OriginalsprogEngelsk
TidsskriftJournal of Child and Adolescent Psychopharmacology
Vol/bind25
Nummer5
Sider (fra-til)432-9
Antal sider8
ISSN1044-5463
DOI
StatusUdgivet - jun. 2015

Se relationer på Aarhus Universitet Citationsformater

ID: 94153633