Per Hove Thomsen

Off-label prescribing of psychotropic drugs in a Danish child and adolescent psychiatric outpatient clinic

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Off-label prescribing of psychotropic drugs in a Danish child and adolescent psychiatric outpatient clinic. / Nielsen, Eva Skovslund; Hellfritzsch, Maja; Sørensen, Merete Juul; Rasmussen, Helle; Thomsen, Per Hove; Laursen, Torben.

I: European Child & Adolescent Psychiatry, Bind 25, Nr. 1, 28.02.2015, s. 25-31.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{4012b2e695814ee7a327e1cf6dd4e3d0,
title = "Off-label prescribing of psychotropic drugs in a Danish child and adolescent psychiatric outpatient clinic",
abstract = "This study aimed to describe the level of off-label treatment with psychotropic drugs at a child and adolescent psychiatric outpatient clinic in Denmark. We performed a cross-sectional study assessing records on patients treated with medicine at two outpatient clinics at the child and adolescent psychiatric ward, on 1 day in 2014. Prescriptions of drugs from ATC group N05-N06 were classified according to label status. Six hundred and fifteen drug prescriptions distributed on nine different drugs were prescribed to 503 children eligible for this study. Overall results showed that 170 of the 615 prescriptions were off-label, which corresponds to 27.6 %. Attention deficit hyperkinetic disorder (ADHD) drugs were prescribed 450 times (73.2 %) of which 11 prescriptions were off-label (2.4 %). Other psychotropic drugs comprised 165 (26.8 %) prescriptions and of these 159 (96.4 %) were off-label. With 106 prescriptions, melatonin was the most prescribed of these drugs; all prescriptions were off-label. The main reasons for classifying prescriptions as off-label were age and indication of treatment. This cross-sectional study reveals that medical treatment of children with other psychotropic drugs than ADHD drugs is usually off-label. ADHD drugs were, as the only drug group, primarily prescribed on-label. Although off-label prescription may be rational and even evidence based, the responsibility in case of, e.g. adverse drug reactions is a challenge, and clinical trials in children should be incited.",
keywords = "children, off-label, child and adolescent psychiatry, psychotropic drugs, outpatient clinic, medication safety",
author = "Nielsen, {Eva Skovslund} and Maja Hellfritzsch and S{\o}rensen, {Merete Juul} and Helle Rasmussen and Thomsen, {Per Hove} and Torben Laursen",
year = "2015",
month = feb,
day = "28",
doi = "10.1007/s00787-015-0699-z",
language = "English",
volume = "25",
pages = "25--31",
journal = "European Child & Adolescent Psychiatry",
issn = "1018-8827",
publisher = "Springer Medizin",
number = "1",

}

RIS

TY - JOUR

T1 - Off-label prescribing of psychotropic drugs in a Danish child and adolescent psychiatric outpatient clinic

AU - Nielsen, Eva Skovslund

AU - Hellfritzsch, Maja

AU - Sørensen, Merete Juul

AU - Rasmussen, Helle

AU - Thomsen, Per Hove

AU - Laursen, Torben

PY - 2015/2/28

Y1 - 2015/2/28

N2 - This study aimed to describe the level of off-label treatment with psychotropic drugs at a child and adolescent psychiatric outpatient clinic in Denmark. We performed a cross-sectional study assessing records on patients treated with medicine at two outpatient clinics at the child and adolescent psychiatric ward, on 1 day in 2014. Prescriptions of drugs from ATC group N05-N06 were classified according to label status. Six hundred and fifteen drug prescriptions distributed on nine different drugs were prescribed to 503 children eligible for this study. Overall results showed that 170 of the 615 prescriptions were off-label, which corresponds to 27.6 %. Attention deficit hyperkinetic disorder (ADHD) drugs were prescribed 450 times (73.2 %) of which 11 prescriptions were off-label (2.4 %). Other psychotropic drugs comprised 165 (26.8 %) prescriptions and of these 159 (96.4 %) were off-label. With 106 prescriptions, melatonin was the most prescribed of these drugs; all prescriptions were off-label. The main reasons for classifying prescriptions as off-label were age and indication of treatment. This cross-sectional study reveals that medical treatment of children with other psychotropic drugs than ADHD drugs is usually off-label. ADHD drugs were, as the only drug group, primarily prescribed on-label. Although off-label prescription may be rational and even evidence based, the responsibility in case of, e.g. adverse drug reactions is a challenge, and clinical trials in children should be incited.

AB - This study aimed to describe the level of off-label treatment with psychotropic drugs at a child and adolescent psychiatric outpatient clinic in Denmark. We performed a cross-sectional study assessing records on patients treated with medicine at two outpatient clinics at the child and adolescent psychiatric ward, on 1 day in 2014. Prescriptions of drugs from ATC group N05-N06 were classified according to label status. Six hundred and fifteen drug prescriptions distributed on nine different drugs were prescribed to 503 children eligible for this study. Overall results showed that 170 of the 615 prescriptions were off-label, which corresponds to 27.6 %. Attention deficit hyperkinetic disorder (ADHD) drugs were prescribed 450 times (73.2 %) of which 11 prescriptions were off-label (2.4 %). Other psychotropic drugs comprised 165 (26.8 %) prescriptions and of these 159 (96.4 %) were off-label. With 106 prescriptions, melatonin was the most prescribed of these drugs; all prescriptions were off-label. The main reasons for classifying prescriptions as off-label were age and indication of treatment. This cross-sectional study reveals that medical treatment of children with other psychotropic drugs than ADHD drugs is usually off-label. ADHD drugs were, as the only drug group, primarily prescribed on-label. Although off-label prescription may be rational and even evidence based, the responsibility in case of, e.g. adverse drug reactions is a challenge, and clinical trials in children should be incited.

KW - children

KW - off-label

KW - child and adolescent psychiatry

KW - psychotropic drugs

KW - outpatient clinic

KW - medication safety

U2 - 10.1007/s00787-015-0699-z

DO - 10.1007/s00787-015-0699-z

M3 - Journal article

C2 - 25724547

VL - 25

SP - 25

EP - 31

JO - European Child & Adolescent Psychiatry

JF - European Child & Adolescent Psychiatry

SN - 1018-8827

IS - 1

ER -