Per Hove Thomsen

Obsessive-compulsive symptom dimensions: Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder

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Obsessive-compulsive symptom dimensions : Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder. / Højgaard, David R.M.A.; Hybel, Katja A; Mortensen, Erik Lykke; Ivarsson, Tord; Nissen, Judith Becker; Weidle, Bernhard; Melin, Karin; Torp, Nor Christian; Dahl, Kitty; Valderhaug, Robert; Skarphedinsson, Gudmundur; Storch, Eric A; Thomsen, Per Hove.

I: Psychiatry Research, Bind 270, 2018, s. 317-323.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Author

Højgaard, David R.M.A. ; Hybel, Katja A ; Mortensen, Erik Lykke ; Ivarsson, Tord ; Nissen, Judith Becker ; Weidle, Bernhard ; Melin, Karin ; Torp, Nor Christian ; Dahl, Kitty ; Valderhaug, Robert ; Skarphedinsson, Gudmundur ; Storch, Eric A ; Thomsen, Per Hove. / Obsessive-compulsive symptom dimensions : Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder. I: Psychiatry Research. 2018 ; Bind 270. s. 317-323.

Bibtex

@article{cbbe60a3107840368266ab9b2e46a70b,
title = "Obsessive-compulsive symptom dimensions: Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder",
abstract = "Our aims were to examine: (1) classes of comorbid disorders in a sample of children and adolescents with Obsessive-Compulsive Disorder (OCD), (2) how these classes relate to obsessive-compulsive symptom dimensions, and (3) the extent to which obsessive-compulsive symptom dimensions predict Cognitive-Behavioral Therapy (CBT) outcome. Participants (N = 269) were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Latent Class Analysis (LCA) was used to identify comorbidity classes. Regression analyses were used to evaluate symptom dimensions as predictors of treatment outcome and their relation to comorbidity classes. Comorbidity was included in the treatment outcome analyses as it can affect outcome. Comorbidity was best categorized by a three-class model and each class was distinctively correlated with the OCD symptom dimensions. Higher scores on the symmetry/hoarding factor increased the chance of responding to CBT by an odds ratio of 1.56 (p = 0.020) when controlled for age, gender, and comorbidity class. The harm/sexual factor (p = 0.675) and contamination/cleaning factor (p = 0.122) did not predict CBT outcome. Three clinically relevant comorbidity subgroups in pediatric OCD were identified. Patients who exhibited higher levels of symmetry/hoarding dimension were more prone to respond to CBT.",
author = "H{\o}jgaard, {David R.M.A.} and Hybel, {Katja A} and Mortensen, {Erik Lykke} and Tord Ivarsson and Nissen, {Judith Becker} and Bernhard Weidle and Karin Melin and Torp, {Nor Christian} and Kitty Dahl and Robert Valderhaug and Gudmundur Skarphedinsson and Storch, {Eric A} and Thomsen, {Per Hove}",
note = "Copyright {\textcopyright} 2018 Elsevier B.V. All rights reserved.",
year = "2018",
doi = "10.1016/j.psychres.2018.09.054",
language = "English",
volume = "270",
pages = "317--323",
journal = "Psychiatry Research",
issn = "0165-1781",
publisher = "Elsevier Ireland Ltd.",

}

RIS

TY - JOUR

T1 - Obsessive-compulsive symptom dimensions

T2 - Association with comorbidity profiles and cognitive-behavioral therapy outcome in pediatric obsessive-compulsive disorder

AU - Højgaard, David R.M.A.

AU - Hybel, Katja A

AU - Mortensen, Erik Lykke

AU - Ivarsson, Tord

AU - Nissen, Judith Becker

AU - Weidle, Bernhard

AU - Melin, Karin

AU - Torp, Nor Christian

AU - Dahl, Kitty

AU - Valderhaug, Robert

AU - Skarphedinsson, Gudmundur

AU - Storch, Eric A

AU - Thomsen, Per Hove

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2018

Y1 - 2018

N2 - Our aims were to examine: (1) classes of comorbid disorders in a sample of children and adolescents with Obsessive-Compulsive Disorder (OCD), (2) how these classes relate to obsessive-compulsive symptom dimensions, and (3) the extent to which obsessive-compulsive symptom dimensions predict Cognitive-Behavioral Therapy (CBT) outcome. Participants (N = 269) were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Latent Class Analysis (LCA) was used to identify comorbidity classes. Regression analyses were used to evaluate symptom dimensions as predictors of treatment outcome and their relation to comorbidity classes. Comorbidity was included in the treatment outcome analyses as it can affect outcome. Comorbidity was best categorized by a three-class model and each class was distinctively correlated with the OCD symptom dimensions. Higher scores on the symmetry/hoarding factor increased the chance of responding to CBT by an odds ratio of 1.56 (p = 0.020) when controlled for age, gender, and comorbidity class. The harm/sexual factor (p = 0.675) and contamination/cleaning factor (p = 0.122) did not predict CBT outcome. Three clinically relevant comorbidity subgroups in pediatric OCD were identified. Patients who exhibited higher levels of symmetry/hoarding dimension were more prone to respond to CBT.

AB - Our aims were to examine: (1) classes of comorbid disorders in a sample of children and adolescents with Obsessive-Compulsive Disorder (OCD), (2) how these classes relate to obsessive-compulsive symptom dimensions, and (3) the extent to which obsessive-compulsive symptom dimensions predict Cognitive-Behavioral Therapy (CBT) outcome. Participants (N = 269) were assessed with the Kiddie Schedule for Affective Disorders and Schizophrenia (K-SADS-PL) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Latent Class Analysis (LCA) was used to identify comorbidity classes. Regression analyses were used to evaluate symptom dimensions as predictors of treatment outcome and their relation to comorbidity classes. Comorbidity was included in the treatment outcome analyses as it can affect outcome. Comorbidity was best categorized by a three-class model and each class was distinctively correlated with the OCD symptom dimensions. Higher scores on the symmetry/hoarding factor increased the chance of responding to CBT by an odds ratio of 1.56 (p = 0.020) when controlled for age, gender, and comorbidity class. The harm/sexual factor (p = 0.675) and contamination/cleaning factor (p = 0.122) did not predict CBT outcome. Three clinically relevant comorbidity subgroups in pediatric OCD were identified. Patients who exhibited higher levels of symmetry/hoarding dimension were more prone to respond to CBT.

U2 - 10.1016/j.psychres.2018.09.054

DO - 10.1016/j.psychres.2018.09.054

M3 - Journal article

C2 - 30290317

VL - 270

SP - 317

EP - 323

JO - Psychiatry Research

JF - Psychiatry Research

SN - 0165-1781

ER -