Per Hove Thomsen

Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents

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Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents. / Nissen, Judith B.; Skarphedinsson, Gudmundur; Weidle, Bernhard; Torp, Nor C.; Lenhard, Fabian; Dahl, Kitty; Melin, Karin Holmgren; Højgaard, Davíd Rúrik Martinsson A; Valderhaug, Robert; Ivarsson, Tord; Thomsen, Per H.

I: Journal of Obsessive-Compulsive and Related Disorders, Bind 9, 01.04.2016, s. 59-65.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Nissen, JB, Skarphedinsson, G, Weidle, B, Torp, NC, Lenhard, F, Dahl, K, Melin, KH, Højgaard, DRMA, Valderhaug, R, Ivarsson, T & Thomsen, PH 2016, 'Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents', Journal of Obsessive-Compulsive and Related Disorders, bind 9, s. 59-65. https://doi.org/10.1016/j.jocrd.2016.03.001

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Author

Nissen, Judith B. ; Skarphedinsson, Gudmundur ; Weidle, Bernhard ; Torp, Nor C. ; Lenhard, Fabian ; Dahl, Kitty ; Melin, Karin Holmgren ; Højgaard, Davíd Rúrik Martinsson A ; Valderhaug, Robert ; Ivarsson, Tord ; Thomsen, Per H. / Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents. I: Journal of Obsessive-Compulsive and Related Disorders. 2016 ; Bind 9. s. 59-65.

Bibtex

@article{83f4515ac8cd4da59bf73231c702ba90,
title = "Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents",
abstract = "Obsessive compulsive disorder (OCD) is a neuropsychiatric entity. The aim was to explore the association of familial OCD, tics, anxiety, and depression with the presentation of OCD in offspring. To our knowledge, this is the first study examining the association of other familial psychiatric disorders with OCD in offspring.A total of 198 families recruited to a Scandinavian multicenter treatment study participated. Characteristics of the child were assessed with standard measures. Family psychiatric disorders were assessed with two methods: a parent interview with open questions and a parent interview with specific questions concerning tics, depression, anxiety, and OCD.A family history of OCD was described in 6{\%} of the probands. No differences were observed between children who had relatives with OCD and children without familial occurrence of OCD. Familial tic disorder was associated with comorbid tics, externalizing disorders, repeating compulsions, and hoarding in the child proband. Familial anxiety was associated with internalizing disorders and comorbid tics, whereas familial depression was associated with somatic obsessions and hoarding in the proband.Our study shows that familial occurrence of other psychiatric disorders is associated with differences in the clinical presentation. Identifying subtypes may have implications for our understanding of the etiology of OCD.",
keywords = "Adolescents, Children, Family, Inheritance, Obsessive-compulsive disorder",
author = "Nissen, {Judith B.} and Gudmundur Skarphedinsson and Bernhard Weidle and Torp, {Nor C.} and Fabian Lenhard and Kitty Dahl and Melin, {Karin Holmgren} and H{\o}jgaard, {Dav{\'i}d R{\'u}rik Martinsson A} and Robert Valderhaug and Tord Ivarsson and Thomsen, {Per H.}",
year = "2016",
month = "4",
day = "1",
doi = "10.1016/j.jocrd.2016.03.001",
language = "English",
volume = "9",
pages = "59--65",
journal = "Journal of Obsessive-Compulsive and Related Disorders",
issn = "2211-3649",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Familial occurrence of tic disorder, anxiety and depression is associated with the clinical presentation of obsessive compulsive disorder (OCD) in children and adolescents

AU - Nissen, Judith B.

AU - Skarphedinsson, Gudmundur

AU - Weidle, Bernhard

AU - Torp, Nor C.

AU - Lenhard, Fabian

AU - Dahl, Kitty

AU - Melin, Karin Holmgren

AU - Højgaard, Davíd Rúrik Martinsson A

AU - Valderhaug, Robert

AU - Ivarsson, Tord

AU - Thomsen, Per H.

PY - 2016/4/1

Y1 - 2016/4/1

N2 - Obsessive compulsive disorder (OCD) is a neuropsychiatric entity. The aim was to explore the association of familial OCD, tics, anxiety, and depression with the presentation of OCD in offspring. To our knowledge, this is the first study examining the association of other familial psychiatric disorders with OCD in offspring.A total of 198 families recruited to a Scandinavian multicenter treatment study participated. Characteristics of the child were assessed with standard measures. Family psychiatric disorders were assessed with two methods: a parent interview with open questions and a parent interview with specific questions concerning tics, depression, anxiety, and OCD.A family history of OCD was described in 6% of the probands. No differences were observed between children who had relatives with OCD and children without familial occurrence of OCD. Familial tic disorder was associated with comorbid tics, externalizing disorders, repeating compulsions, and hoarding in the child proband. Familial anxiety was associated with internalizing disorders and comorbid tics, whereas familial depression was associated with somatic obsessions and hoarding in the proband.Our study shows that familial occurrence of other psychiatric disorders is associated with differences in the clinical presentation. Identifying subtypes may have implications for our understanding of the etiology of OCD.

AB - Obsessive compulsive disorder (OCD) is a neuropsychiatric entity. The aim was to explore the association of familial OCD, tics, anxiety, and depression with the presentation of OCD in offspring. To our knowledge, this is the first study examining the association of other familial psychiatric disorders with OCD in offspring.A total of 198 families recruited to a Scandinavian multicenter treatment study participated. Characteristics of the child were assessed with standard measures. Family psychiatric disorders were assessed with two methods: a parent interview with open questions and a parent interview with specific questions concerning tics, depression, anxiety, and OCD.A family history of OCD was described in 6% of the probands. No differences were observed between children who had relatives with OCD and children without familial occurrence of OCD. Familial tic disorder was associated with comorbid tics, externalizing disorders, repeating compulsions, and hoarding in the child proband. Familial anxiety was associated with internalizing disorders and comorbid tics, whereas familial depression was associated with somatic obsessions and hoarding in the proband.Our study shows that familial occurrence of other psychiatric disorders is associated with differences in the clinical presentation. Identifying subtypes may have implications for our understanding of the etiology of OCD.

KW - Adolescents

KW - Children

KW - Family

KW - Inheritance

KW - Obsessive-compulsive disorder

UR - http://www.scopus.com/inward/record.url?scp=84961181136&partnerID=8YFLogxK

U2 - 10.1016/j.jocrd.2016.03.001

DO - 10.1016/j.jocrd.2016.03.001

M3 - Journal article

AN - SCOPUS:84961181136

VL - 9

SP - 59

EP - 65

JO - Journal of Obsessive-Compulsive and Related Disorders

JF - Journal of Obsessive-Compulsive and Related Disorders

SN - 2211-3649

ER -