Per Hove Thomsen

Effectiveness of cognitive behavior treatment for pediatric obsessive-compulsive disorder: Acute outcomes from the Nordic Long-term OCD Treatment Study (NordLOTS)

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Nor Christian Torp, Centre for Child and Adolescent Mental Health, Oslo, Norge
  • Kitty Dahl, Centre for Child and Adolescent Mental Health, Oslo, Norge
  • Gudmundur Skarphedinsson, Centre for Child and Adolescent Mental Health, Oslo, Norge
  • Per Hove Thomsen
  • Robert Valderhaug, Regional Centre for Child and Youth Mental Health and Child Welfare, Trondheim, Norge
  • Bernhard Weidle
  • ,
  • Karin Holmgren Melin, Sahlgrenska University Hospital, Gothenburg, Sverige
  • Katja Anna Hybel
  • Judith Becker Nissen
  • Fabian Lenhard, Karolinska Institute, Department of Clinical Neuroscience, Stockholm, Sverige
  • Tore Wentzel-Larsen, Centre for Child and Adolescent Mental Health, Oslo, Norge
  • Martin E Franklin, Department of Psychiatry, University of Pennsylvania School of Medicine, USA
  • Tord Ivarsson, Centre for Child and Adolescent Mental Health, Oslo, Norge

OBJECTIVE: The purpose of this study was to examine the acute effectiveness of manualized exposure-based CBT with a family-based treatment, as an initial treatment for pediatric OCD delivered in regular community child and adolescents outpatient clinics. The report summarizes outcome of the first treatment step in the NordLOTS, which was conducted in Denmark, Sweden and Norway.

METHOD: 269 participants, age 7-17, with OCD, received treatment for 14 weekly sessions. Treatment response was defined as CY-BOCS score of ≤15 at post treatment.

RESULTS: 241 participants (89.6%) completed all 14 weeks of treatment. Treatment response among the completers was 72.6% (95% CI 66.7%-77.9%). Mixed effects model revealed a statistically significant effect of time F(1,479) = 130.434. Mean symptom reduction on the CY-BOCS was 52.9% (SD = 30.9). The estimated within-group effect size between baseline and post treatment was 1.58 (95% CI: 1.37-1.80).

CONCLUSION: This study found that manualized CBT can be applied effectively in community mental health clinics. These findings underscore the feasibility of implementing exposure-based CBT for pediatric OCD in a regular child and adolescent mental health setting.

CLINICAL TRIALS REGISTRATION INFORMATION: This study was registered in Current Controlled Trials; Nordic Long-term Obsessive-compulsive disorder (OCD) Treatment Study (www.controlled-trials.com ISRCTN66385119).

OriginalsprogEngelsk
TidsskriftBehaviour Research and Therapy
Vol/bind64
Sider (fra-til)15-23
Antal sider9
ISSN0005-7967
DOI
StatusUdgivet - jan. 2015

    Forskningsområder

  • OCD, Cognitive behavioural therapy, Exposure and response prevention, Treatment outcome

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