Per Hove Thomsen

Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report

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Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report. / Vandborg, Sanne Kjær; Hartmann, Tue Borst; Bennedsen, Birgit Egedal; Pedersen, Anders Degn; Eskildsen, Anita; Videbech, Poul Bror Hemming; Thomsen, Per Hove.

I: Nordic Journal of Psychiatry, Bind 66, Nr. 1, 2012, s. 60-67.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{dfd16726814443c0b213b6d986b7345e,
title = "Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report",
abstract = "Background: Neuropsychological and neuroimaging studies have documented that patients with obsessive-compulsive disorder (OCD) have cognitive difficulties dependent upon fronto-striatal circuits in the brain. It is, however, unclear whether the cognitive difficulties change after treatment. Answering this question could help establish whether cognitive difficulties in OCD are state dependent or more trait-like. Aim: To determine whether cognitive functions in OCD change after treatment, based on a systematic literature review, supplemented by a double case report of monozygotic twins with OCD. Methods: For the literature review, systematic searches were conducted in PubMed, Embase and PsycINFO from the earliest dates available to September 2010. For the double case report, monozygotic twins underwent blood samples and magnetic resonance imaging before treatment with cognitive behavioral therapy (CBT), antidepressants and small doses of antipsychotic medication. Before and after CBT they were assessed with measures of content and severity of OCD symptoms, and with a comprehensive battery of neuropsychological tests to assess cognitive functions. Results: Results from the studies under review (n = 14) were so inconsistent that it could not be concluded whether cognitive functions in OCD change after treatment. The twins improved some of their cognitive functions after treatment. Conclusions: A better understanding of whether cognitive dysfunctions in OCD are state dependent or trait-like could bring important implications in understanding the pathology and future treatment of OCD.",
author = "Vandborg, {Sanne Kj{\ae}r} and Hartmann, {Tue Borst} and Bennedsen, {Birgit Egedal} and Pedersen, {Anders Degn} and Anita Eskildsen and Videbech, {Poul Bror Hemming} and Thomsen, {Per Hove}",
year = "2012",
doi = "10.3109/08039488.2011.626869",
language = "English",
volume = "66",
pages = "60--67",
journal = "Nordic Journal of Psychiatry",
issn = "0803-9488",
publisher = "Taylor & francis",
number = "1",

}

RIS

TY - JOUR

T1 - Do cognitive functions in obsessive-compulsive disorder change after treatment? A systematic review and a double case report

AU - Vandborg, Sanne Kjær

AU - Hartmann, Tue Borst

AU - Bennedsen, Birgit Egedal

AU - Pedersen, Anders Degn

AU - Eskildsen, Anita

AU - Videbech, Poul Bror Hemming

AU - Thomsen, Per Hove

PY - 2012

Y1 - 2012

N2 - Background: Neuropsychological and neuroimaging studies have documented that patients with obsessive-compulsive disorder (OCD) have cognitive difficulties dependent upon fronto-striatal circuits in the brain. It is, however, unclear whether the cognitive difficulties change after treatment. Answering this question could help establish whether cognitive difficulties in OCD are state dependent or more trait-like. Aim: To determine whether cognitive functions in OCD change after treatment, based on a systematic literature review, supplemented by a double case report of monozygotic twins with OCD. Methods: For the literature review, systematic searches were conducted in PubMed, Embase and PsycINFO from the earliest dates available to September 2010. For the double case report, monozygotic twins underwent blood samples and magnetic resonance imaging before treatment with cognitive behavioral therapy (CBT), antidepressants and small doses of antipsychotic medication. Before and after CBT they were assessed with measures of content and severity of OCD symptoms, and with a comprehensive battery of neuropsychological tests to assess cognitive functions. Results: Results from the studies under review (n = 14) were so inconsistent that it could not be concluded whether cognitive functions in OCD change after treatment. The twins improved some of their cognitive functions after treatment. Conclusions: A better understanding of whether cognitive dysfunctions in OCD are state dependent or trait-like could bring important implications in understanding the pathology and future treatment of OCD.

AB - Background: Neuropsychological and neuroimaging studies have documented that patients with obsessive-compulsive disorder (OCD) have cognitive difficulties dependent upon fronto-striatal circuits in the brain. It is, however, unclear whether the cognitive difficulties change after treatment. Answering this question could help establish whether cognitive difficulties in OCD are state dependent or more trait-like. Aim: To determine whether cognitive functions in OCD change after treatment, based on a systematic literature review, supplemented by a double case report of monozygotic twins with OCD. Methods: For the literature review, systematic searches were conducted in PubMed, Embase and PsycINFO from the earliest dates available to September 2010. For the double case report, monozygotic twins underwent blood samples and magnetic resonance imaging before treatment with cognitive behavioral therapy (CBT), antidepressants and small doses of antipsychotic medication. Before and after CBT they were assessed with measures of content and severity of OCD symptoms, and with a comprehensive battery of neuropsychological tests to assess cognitive functions. Results: Results from the studies under review (n = 14) were so inconsistent that it could not be concluded whether cognitive functions in OCD change after treatment. The twins improved some of their cognitive functions after treatment. Conclusions: A better understanding of whether cognitive dysfunctions in OCD are state dependent or trait-like could bring important implications in understanding the pathology and future treatment of OCD.

U2 - 10.3109/08039488.2011.626869

DO - 10.3109/08039488.2011.626869

M3 - Journal article

C2 - 22050379

VL - 66

SP - 60

EP - 67

JO - Nordic Journal of Psychiatry

JF - Nordic Journal of Psychiatry

SN - 0803-9488

IS - 1

ER -