Per Hove Thomsen

Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment. / Jensen, Sanne; Højgaard, Davíð R.M.A.; Hybel, Katja A.; Mortensen, Erik Lykke; Skarphedinsson, Gudmundur; Melin, Karin; Ivarsson, Tord; Nissen, Judith Becker; Weidle, Bernhard; Valderhaug, Robert; Torp, Nor Christian; Dahl, Kitty; Compton, Scott; Thomsen, Per Hove.

I: Journal of Child Psychology and Psychiatry and Allied Disciplines, Bind 61, Nr. 9, 2020, s. 969-978.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Jensen, S, Højgaard, DRMA, Hybel, KA, Mortensen, EL, Skarphedinsson, G, Melin, K, Ivarsson, T, Nissen, JB, Weidle, B, Valderhaug, R, Torp, NC, Dahl, K, Compton, S & Thomsen, PH 2020, 'Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment', Journal of Child Psychology and Psychiatry and Allied Disciplines, bind 61, nr. 9, s. 969-978. https://doi.org/10.1111/jcpp.13155

APA

Jensen, S., Højgaard, D. R. M. A., Hybel, K. A., Mortensen, E. L., Skarphedinsson, G., Melin, K., Ivarsson, T., Nissen, J. B., Weidle, B., Valderhaug, R., Torp, N. C., Dahl, K., Compton, S., & Thomsen, P. H. (2020). Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment. Journal of Child Psychology and Psychiatry and Allied Disciplines, 61(9), 969-978. https://doi.org/10.1111/jcpp.13155

CBE

Jensen S, Højgaard DRMA, Hybel KA, Mortensen EL, Skarphedinsson G, Melin K, Ivarsson T, Nissen JB, Weidle B, Valderhaug R, Torp NC, Dahl K, Compton S, Thomsen PH. 2020. Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment. Journal of Child Psychology and Psychiatry and Allied Disciplines. 61(9):969-978. https://doi.org/10.1111/jcpp.13155

MLA

Vancouver

Jensen S, Højgaard DRMA, Hybel KA, Mortensen EL, Skarphedinsson G, Melin K o.a. Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment. Journal of Child Psychology and Psychiatry and Allied Disciplines. 2020;61(9):969-978. https://doi.org/10.1111/jcpp.13155

Author

Jensen, Sanne ; Højgaard, Davíð R.M.A. ; Hybel, Katja A. ; Mortensen, Erik Lykke ; Skarphedinsson, Gudmundur ; Melin, Karin ; Ivarsson, Tord ; Nissen, Judith Becker ; Weidle, Bernhard ; Valderhaug, Robert ; Torp, Nor Christian ; Dahl, Kitty ; Compton, Scott ; Thomsen, Per Hove. / Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment. I: Journal of Child Psychology and Psychiatry and Allied Disciplines. 2020 ; Bind 61, Nr. 9. s. 969-978.

Bibtex

@article{129c2a81a66a44bf877ce6322e3028ec,
title = "Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment",
abstract = "Background: First-line treatments for pediatric obsessive–compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. Method: The study included 269 OCD patients aged 7−17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. Trial registry: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. Results: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, gender, symptom presentation, insight, avoidance, and comorbidity. Conclusions: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning symptoms and reduced insight who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response.",
keywords = "children and adolescents, latent class growth analysis, longitudinal study, Obsessive–compulsive disorder, outcome predictors, stepped-care treatment, trajectories, OCD TREATMENT, SERTRALINE, FOLLOW-UP, NONRESPONDERS, CHILDREN, ADOLESCENTS, PREDICTORS, COGNITIVE-BEHAVIOR THERAPY, GLOBAL ASSESSMENT SCALE, Obsessive-compulsive disorder, OUTCOMES",
author = "Sanne Jensen and H{\o}jgaard, {Dav{\'i}{\dh} R.M.A.} and Hybel, {Katja A.} and Mortensen, {Erik Lykke} and Gudmundur Skarphedinsson and Karin Melin and Tord Ivarsson and Nissen, {Judith Becker} and Bernhard Weidle and Robert Valderhaug and Torp, {Nor Christian} and Kitty Dahl and Scott Compton and Thomsen, {Per Hove}",
year = "2020",
doi = "10.1111/jcpp.13155",
language = "English",
volume = "61",
pages = "969--978",
journal = "Journal of Child Psychology & Psychiatry",
issn = "0021-9630",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "9",

}

RIS

TY - JOUR

T1 - Distinct trajectories of long-term symptom severity in pediatric obsessive–compulsive disorder during and after stepped-care treatment

AU - Jensen, Sanne

AU - Højgaard, Davíð R.M.A.

AU - Hybel, Katja A.

AU - Mortensen, Erik Lykke

AU - Skarphedinsson, Gudmundur

AU - Melin, Karin

AU - Ivarsson, Tord

AU - Nissen, Judith Becker

AU - Weidle, Bernhard

AU - Valderhaug, Robert

AU - Torp, Nor Christian

AU - Dahl, Kitty

AU - Compton, Scott

AU - Thomsen, Per Hove

PY - 2020

Y1 - 2020

N2 - Background: First-line treatments for pediatric obsessive–compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. Method: The study included 269 OCD patients aged 7−17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. Trial registry: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. Results: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, gender, symptom presentation, insight, avoidance, and comorbidity. Conclusions: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning symptoms and reduced insight who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response.

AB - Background: First-line treatments for pediatric obsessive–compulsive disorder (OCD) include exposure-based cognitive-behavioral therapy (CBT) and selective serotonin reuptake inhibitors (SSRIs). No studies have thus far identified distinct classes and associated predictors of long-term symptom severity during and after treatment. Yet, these could form the basis for more personalized treatment in pediatric OCD. Method: The study included 269 OCD patients aged 7−17 years from the Nordic Long-term OCD Treatment Study (NordLOTS). All participants received stepped-care treatment starting with 14 weekly sessions of manualized CBT. Nonresponders were randomized to either prolonged CBT or SSRIs. Symptom severity was assessed using the Children's Yale-Brown Obsessive-Compulsive Scale at seven time points from pre- to post-treatment and over a three-year follow-up. Latent class growth analysis (LCGA) was performed to identify latent classes of symptom severity trajectories. Univariate and multivariate analyses were used to detect differences between classes and identify predictors of trajectory class membership including several clinical and demographic variables. Trial registry: Nordic Long-term Obsessive-Compulsive Disorder (OCD) Treatment Study; www.controlled-trials.com; ISRCTN66385119. Results: Three LCGA classes were identified: (a) acute, sustained responders (54.6%); (b) slow, continued responders (23.4%); and (c) limited long-term responders (21.9%). Class membership was predicted by distinct baseline characteristics pertaining to age, gender, symptom presentation, insight, avoidance, and comorbidity. Conclusions: The LCGA suggests three distinct trajectory classes of long-term symptom severity during and after treatment in pediatric OCD with different clinical profiles at pretreatment. The results point to required clinical attention for adolescent patients with contamination/cleaning symptoms and reduced insight who do not show convincing responses to first-line treatment even though they may have reached the established cutoff for treatment response.

KW - children and adolescents

KW - latent class growth analysis

KW - longitudinal study

KW - Obsessive–compulsive disorder

KW - outcome predictors

KW - stepped-care treatment

KW - trajectories

KW - OCD TREATMENT

KW - SERTRALINE

KW - FOLLOW-UP

KW - NONRESPONDERS

KW - CHILDREN

KW - ADOLESCENTS

KW - PREDICTORS

KW - COGNITIVE-BEHAVIOR THERAPY

KW - GLOBAL ASSESSMENT SCALE

KW - Obsessive-compulsive disorder

KW - OUTCOMES

UR - http://www.scopus.com/inward/record.url?scp=85075347016&partnerID=8YFLogxK

U2 - 10.1111/jcpp.13155

DO - 10.1111/jcpp.13155

M3 - Journal article

C2 - 31736082

AN - SCOPUS:85075347016

VL - 61

SP - 969

EP - 978

JO - Journal of Child Psychology & Psychiatry

JF - Journal of Child Psychology & Psychiatry

SN - 0021-9630

IS - 9

ER -