Per Hove Thomsen

Association between Attention-Deficit Hyperactivity Disorder in childhood and schizophrenia later in adulthood

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • S Dalsgaard, Danmark
  • Preben Bo Mortensen, Danmark
  • M Frydenberg
  • C M Maibing, University of Copenhagen, Danmark
  • M Nordentoft, The Lundbeck Foundation Initiative for Integrative Psychiatric Research, iPSYCH, Denmark., Danmark
  • P H Thomsen
Purpose: To estimate the risk of schizophrenia in adulthood among children and adolescents with ADHD compared to the background population.
Subjects/materials and methods: Two hundred and eight youths with ADHD (183 boys; 25 girls) were followed prospectively. Diagnoses of schizophrenia were obtained from The Danish Psychiatric Central Register. The relative risk (RR) of schizophrenia for cases with ADHD, compared to the normal population, was calculated as risk ratios. Hazard ratios (HR's) by Cox regression were calculated in the predictor analysis.
Results: Mean age for ADHD cases at follow-up was 31.1 years. Schizophrenia diagnoses were given to 3.8% of these cases. Compared to the general population, RR of schizophrenia in cases with ADHD was 4.3 (95% CI 1.9-8.57).
Discussion of conclusion: This prospective follow-up study found children with ADHD to be a higher risk of later schizophrenia than controls. If replicated, these results warrant increased focus on the possible emergence symptoms of schizophrenia or schizophreniform psychosis during clinical follow-up of patients with ADHD.
OriginalsprogEngelsk
TidsskriftEuropean Psychiatry
Vol/bind29
Sider (fra-til)259-263
Antal sider5
ISSN0924-9338
DOI
StatusUdgivet - 6 sep. 2014

Bibliografisk note

In press feb 14

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