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Nina Aagaard Poulsen

Genetic parameters for fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

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Genetic parameters for fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach. / Krag, Kristian; Poulsen, Nina Aagaard; Larsen, Mette Krogh; Larsen, Lotte Bach; Buitenhuis, Albert Johannes.

I: B M C Genetics, Bind 14, Nr. 79, 09.2013, s. 1-10.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{9774100910fb4b4fb29fd05837e273e6,
title = "Genetic parameters for fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach",
abstract = "For several years, in human nutrition there has been a focus on the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) found in bovine milk. The positive health-related properties of UFA versus SFA have increased the demand for food products with a higher proportion of UFA. To be able to change the UFA and SFA content of the milk by breeding it is important to know whether there is a genetic component underlying the individual FA in the milk. We have estimated the heritability for individual FA in the milk of Danish Holstein. For this purpose we used information of SNP markers instead of thetraditional pedigree relationships.ResultsEstimates of heritability were moderate within the range of 0.10 for C18:1trans-11 to 0.34 for C8:0 and C10:0, whereas the estimates for saturated fatty acids and unsat urated fatty acids were 0.14 and 0.18, respectively. Posterior standard deviations were in the range from 0.07 to 0.17. The correlation estimates showed a general pattern of two groups, one group mainly consisting of saturated fatty acids and one group mainly consisting of unsaturated fatty acids. The phenotypic correlation ranged from −0.95 (saturated fatty acids a nd unsaturated fatty acids) to 0.99 (unsaturated fatty acids and monounsaturated fatty aci ds) and the genomic correlation for fatty acids ranged from −0.29 to 0.91. Conclusions The heritability estimates obtained in this study are in general accordance with heritability estimates from studies using pedigree data and/or a genomic relationship matrix in thecontext of a REML approach. SFA and UFA expressed a strong negative phenotypic correlation and a weaker genetic correlation. This is in accordance with the theory that SFA is synthesized de novo, while UFA can be regulated independently from the regulation of SFA by the feeding regime",
author = "Kristian Krag and Poulsen, {Nina Aagaard} and Larsen, {Mette Krogh} and Larsen, {Lotte Bach} and Buitenhuis, {Albert Johannes}",
year = "2013",
month = sep,
doi = "10.1186/1471-2156-14-79",
language = "English",
volume = "14",
pages = "1--10",
journal = "B M C Genetics",
issn = "1471-2156",
publisher = "BioMed Central Ltd.",
number = "79",

}

RIS

TY - JOUR

T1 - Genetic parameters for fatty acids in Danish Holstein cattle based on SNP markers using a Bayesian approach

AU - Krag, Kristian

AU - Poulsen, Nina Aagaard

AU - Larsen, Mette Krogh

AU - Larsen, Lotte Bach

AU - Buitenhuis, Albert Johannes

PY - 2013/9

Y1 - 2013/9

N2 - For several years, in human nutrition there has been a focus on the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) found in bovine milk. The positive health-related properties of UFA versus SFA have increased the demand for food products with a higher proportion of UFA. To be able to change the UFA and SFA content of the milk by breeding it is important to know whether there is a genetic component underlying the individual FA in the milk. We have estimated the heritability for individual FA in the milk of Danish Holstein. For this purpose we used information of SNP markers instead of thetraditional pedigree relationships.ResultsEstimates of heritability were moderate within the range of 0.10 for C18:1trans-11 to 0.34 for C8:0 and C10:0, whereas the estimates for saturated fatty acids and unsat urated fatty acids were 0.14 and 0.18, respectively. Posterior standard deviations were in the range from 0.07 to 0.17. The correlation estimates showed a general pattern of two groups, one group mainly consisting of saturated fatty acids and one group mainly consisting of unsaturated fatty acids. The phenotypic correlation ranged from −0.95 (saturated fatty acids a nd unsaturated fatty acids) to 0.99 (unsaturated fatty acids and monounsaturated fatty aci ds) and the genomic correlation for fatty acids ranged from −0.29 to 0.91. Conclusions The heritability estimates obtained in this study are in general accordance with heritability estimates from studies using pedigree data and/or a genomic relationship matrix in thecontext of a REML approach. SFA and UFA expressed a strong negative phenotypic correlation and a weaker genetic correlation. This is in accordance with the theory that SFA is synthesized de novo, while UFA can be regulated independently from the regulation of SFA by the feeding regime

AB - For several years, in human nutrition there has been a focus on the proportion of unsaturated fatty acids (UFA) and saturated fatty acids (SFA) found in bovine milk. The positive health-related properties of UFA versus SFA have increased the demand for food products with a higher proportion of UFA. To be able to change the UFA and SFA content of the milk by breeding it is important to know whether there is a genetic component underlying the individual FA in the milk. We have estimated the heritability for individual FA in the milk of Danish Holstein. For this purpose we used information of SNP markers instead of thetraditional pedigree relationships.ResultsEstimates of heritability were moderate within the range of 0.10 for C18:1trans-11 to 0.34 for C8:0 and C10:0, whereas the estimates for saturated fatty acids and unsat urated fatty acids were 0.14 and 0.18, respectively. Posterior standard deviations were in the range from 0.07 to 0.17. The correlation estimates showed a general pattern of two groups, one group mainly consisting of saturated fatty acids and one group mainly consisting of unsaturated fatty acids. The phenotypic correlation ranged from −0.95 (saturated fatty acids a nd unsaturated fatty acids) to 0.99 (unsaturated fatty acids and monounsaturated fatty aci ds) and the genomic correlation for fatty acids ranged from −0.29 to 0.91. Conclusions The heritability estimates obtained in this study are in general accordance with heritability estimates from studies using pedigree data and/or a genomic relationship matrix in thecontext of a REML approach. SFA and UFA expressed a strong negative phenotypic correlation and a weaker genetic correlation. This is in accordance with the theory that SFA is synthesized de novo, while UFA can be regulated independently from the regulation of SFA by the feeding regime

U2 - 10.1186/1471-2156-14-79

DO - 10.1186/1471-2156-14-79

M3 - Journal article

C2 - 24024882

VL - 14

SP - 1

EP - 10

JO - B M C Genetics

JF - B M C Genetics

SN - 1471-2156

IS - 79

ER -