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Nina Aagaard Poulsen

Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. / Gregersen, Vivi Raundahl; Gustavsson, F; Glantz, M; Christensen, Ole Fredslund; Stålhammar, Hans; Andrén, A; Lindmark-Månsson, H; Poulsen, Nina Aagaard; Larsen, Lotte Bach; Paulsson, Marie; Bendixen, Christian.

I: Journal of Dairy Science, Bind 98, 02.2015, s. 1261-1272.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Gregersen, VR, Gustavsson, F, Glantz, M, Christensen, OF, Stålhammar, H, Andrén, A, Lindmark-Månsson, H, Poulsen, NA, Larsen, LB, Paulsson, M & Bendixen, C 2015, 'Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels', Journal of Dairy Science, bind 98, s. 1261-1272. https://doi.org/10.3168/jds.2014-8136

APA

Gregersen, V. R., Gustavsson, F., Glantz, M., Christensen, O. F., Stålhammar, H., Andrén, A., Lindmark-Månsson, H., Poulsen, N. A., Larsen, L. B., Paulsson, M., & Bendixen, C. (2015). Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. Journal of Dairy Science, 98, 1261-1272. https://doi.org/10.3168/jds.2014-8136

CBE

Gregersen VR, Gustavsson F, Glantz M, Christensen OF, Stålhammar H, Andrén A, Lindmark-Månsson H, Poulsen NA, Larsen LB, Paulsson M, Bendixen C. 2015. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. Journal of Dairy Science. 98:1261-1272. https://doi.org/10.3168/jds.2014-8136

MLA

Vancouver

Gregersen VR, Gustavsson F, Glantz M, Christensen OF, Stålhammar H, Andrén A o.a. Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. Journal of Dairy Science. 2015 feb;98:1261-1272. https://doi.org/10.3168/jds.2014-8136

Author

Gregersen, Vivi Raundahl ; Gustavsson, F ; Glantz, M ; Christensen, Ole Fredslund ; Stålhammar, Hans ; Andrén, A ; Lindmark-Månsson, H ; Poulsen, Nina Aagaard ; Larsen, Lotte Bach ; Paulsson, Marie ; Bendixen, Christian. / Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels. I: Journal of Dairy Science. 2015 ; Bind 98. s. 1261-1272.

Bibtex

@article{e58d15711e194dda9b318378b7e39b60,
title = "Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels",
abstract = "Optimizing cheese yield and quality is of central importance to cheese manufacturing. The yield is associated with the time it takes before the gel has an optimal consistency for further processing, and it is well known that gel formation differs between individual milk samples. By identifying genomic regions affecting traits related to rennet-induced gelation, the aim of this study was to identify potential candidate genes affecting these traits. Hence, rennet-induced gelation, including rennet coagulation time, gel strength, and yield stress, was measured in skim milk samples collected from 379 animals of the Swedish Red breed using low-amplitude oscillation measurements. All animals had genotypes for almost 621,000 segregating single nucleotide polymorphisms (SNP), identified using the Bovine HD SNPChip (Illumina Inc., San Diego, CA). The genome was scanned for associations, haplotypes based on SNP sets comprising highly associated SNP were inferred, and the effects of the 2 most common haplotypes within each region were analyzed using mixed models. Even though the number of animals was relatively small, a total of 21 regions were identified, with 4 regions showing association with more than one trait. A major quantitative trait locus for all traits was identified around the casein cluster explaining between 9.3 to 15.2% of the phenotypic variation of the different traits. In addition, 3 other possible candidate genes were identified; that is, UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyl-transferase 1 (GALNT1), playing a role in O-glycosylation of κ-casein, and 2 cathepsins, CTSZ and CTSC, possibly involved in proteolysis of milk proteins. We have shown that other genes than the casein genes themselves may be involved in the regulation of gelation traits. However, additional analysis is needed to confirm these results. To our knowledge, this is the first study identifying quantitative trait loci affecting rennet-induced gelation of skim milk through a high-density genome-wide association study",
author = "Gregersen, {Vivi Raundahl} and F Gustavsson and M Glantz and Christensen, {Ole Fredslund} and Hans St{\aa}lhammar and A Andr{\'e}n and H Lindmark-M{\aa}nsson and Poulsen, {Nina Aagaard} and Larsen, {Lotte Bach} and Marie Paulsson and Christian Bendixen",
year = "2015",
month = feb,
doi = "10.3168/jds.2014-8136",
language = "English",
volume = "98",
pages = "1261--1272",
journal = "Journal of Dairy Science",
issn = "0022-0302",
publisher = "Elsevier Inc.",

}

RIS

TY - JOUR

T1 - Bovine chromosomal regions affecting rheological traits in rennet-induced skim milk gels

AU - Gregersen, Vivi Raundahl

AU - Gustavsson, F

AU - Glantz, M

AU - Christensen, Ole Fredslund

AU - Stålhammar, Hans

AU - Andrén, A

AU - Lindmark-Månsson, H

AU - Poulsen, Nina Aagaard

AU - Larsen, Lotte Bach

AU - Paulsson, Marie

AU - Bendixen, Christian

PY - 2015/2

Y1 - 2015/2

N2 - Optimizing cheese yield and quality is of central importance to cheese manufacturing. The yield is associated with the time it takes before the gel has an optimal consistency for further processing, and it is well known that gel formation differs between individual milk samples. By identifying genomic regions affecting traits related to rennet-induced gelation, the aim of this study was to identify potential candidate genes affecting these traits. Hence, rennet-induced gelation, including rennet coagulation time, gel strength, and yield stress, was measured in skim milk samples collected from 379 animals of the Swedish Red breed using low-amplitude oscillation measurements. All animals had genotypes for almost 621,000 segregating single nucleotide polymorphisms (SNP), identified using the Bovine HD SNPChip (Illumina Inc., San Diego, CA). The genome was scanned for associations, haplotypes based on SNP sets comprising highly associated SNP were inferred, and the effects of the 2 most common haplotypes within each region were analyzed using mixed models. Even though the number of animals was relatively small, a total of 21 regions were identified, with 4 regions showing association with more than one trait. A major quantitative trait locus for all traits was identified around the casein cluster explaining between 9.3 to 15.2% of the phenotypic variation of the different traits. In addition, 3 other possible candidate genes were identified; that is, UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyl-transferase 1 (GALNT1), playing a role in O-glycosylation of κ-casein, and 2 cathepsins, CTSZ and CTSC, possibly involved in proteolysis of milk proteins. We have shown that other genes than the casein genes themselves may be involved in the regulation of gelation traits. However, additional analysis is needed to confirm these results. To our knowledge, this is the first study identifying quantitative trait loci affecting rennet-induced gelation of skim milk through a high-density genome-wide association study

AB - Optimizing cheese yield and quality is of central importance to cheese manufacturing. The yield is associated with the time it takes before the gel has an optimal consistency for further processing, and it is well known that gel formation differs between individual milk samples. By identifying genomic regions affecting traits related to rennet-induced gelation, the aim of this study was to identify potential candidate genes affecting these traits. Hence, rennet-induced gelation, including rennet coagulation time, gel strength, and yield stress, was measured in skim milk samples collected from 379 animals of the Swedish Red breed using low-amplitude oscillation measurements. All animals had genotypes for almost 621,000 segregating single nucleotide polymorphisms (SNP), identified using the Bovine HD SNPChip (Illumina Inc., San Diego, CA). The genome was scanned for associations, haplotypes based on SNP sets comprising highly associated SNP were inferred, and the effects of the 2 most common haplotypes within each region were analyzed using mixed models. Even though the number of animals was relatively small, a total of 21 regions were identified, with 4 regions showing association with more than one trait. A major quantitative trait locus for all traits was identified around the casein cluster explaining between 9.3 to 15.2% of the phenotypic variation of the different traits. In addition, 3 other possible candidate genes were identified; that is, UDP-N-acetyl-α-d-galactosamine:polypeptide N-acetylgalactosaminyl-transferase 1 (GALNT1), playing a role in O-glycosylation of κ-casein, and 2 cathepsins, CTSZ and CTSC, possibly involved in proteolysis of milk proteins. We have shown that other genes than the casein genes themselves may be involved in the regulation of gelation traits. However, additional analysis is needed to confirm these results. To our knowledge, this is the first study identifying quantitative trait loci affecting rennet-induced gelation of skim milk through a high-density genome-wide association study

U2 - 10.3168/jds.2014-8136

DO - 10.3168/jds.2014-8136

M3 - Journal article

C2 - 25497812

VL - 98

SP - 1261

EP - 1272

JO - Journal of Dairy Science

JF - Journal of Dairy Science

SN - 0022-0302

ER -