Niels Okkels

Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study

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Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study. / Horsager, Jacob; Walter, Uwe; Fedorova, Tatyana D; Andersen, Katrine B; Skjærbæk, Casper; Knudsen, Karoline; Okkels, Niels; von Weitzel-Mudersbach, Paul; Dyrskog, Stig Eric; Bergholt, Bo; Borghammer, Per.

I: Frontiers in Neurology, Bind 12, 681413, 06.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{5720f350f70f466bb4d0707aa8988cce,
title = "Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study",
abstract = "Background: Vagal parasympathetic neurons are prone to degeneration in Parkinson's disease (PD). High-resolution ultrasound can precisely estimate the cross-sectional (CSA) area of peripheral nerves. Here, we tested the hypothesis that vagus CSA is reduced in PD. Methods: We included 56 healthy controls (HCs) and 63 patients with PD. Using a high-end ultrasound system equipped with a high-frequency transducer, five images were obtained of each nerve. The hypoechoic neuronal tissue was delineated offline with dedicated software and the CSA extracted. Results: In the initial PD vs. HC comparison, no statistically significant differences were observed in mean left vagus CSA (HC: 1.97 mm2, PD: 1.89 mm2, P = 0.36) nor in mean right vagus CSA (HC: 2.37 mm2, PD: 2.23 mm2, P = 0.17). The right vagus CSA was significantly larger than the left vagus CSA in both groups (P < 0.0001). Females were overrepresented in the HC group and presented with generally smaller vagus CSAs. Consequently, sex-adjusted CSA was significantly smaller for the right vagus nerve of the PD group (P = 0.041), but not for the left. Conclusion: A small but significant reduction in sex-adjusted right vagus CSA was observed in patients with PD. The left vagus CSA was not significantly reduced in patients with PD. Ultrasound may not be a suitable method to detecting vagal axonal loss in individual patients.",
author = "Jacob Horsager and Uwe Walter and Fedorova, {Tatyana D} and Andersen, {Katrine B} and Casper Skj{\ae}rb{\ae}k and Karoline Knudsen and Niels Okkels and {von Weitzel-Mudersbach}, Paul and Dyrskog, {Stig Eric} and Bo Bergholt and Per Borghammer",
note = "Copyright {\textcopyright} 2021 Horsager, Walter, Fedorova, Andersen, Skj{\ae}rb{\ae}k, Knudsen, Okkels, von Weitzel-Mudersbach, Dyrskog, Bergholt and Borghammer.",
year = "2021",
month = jun,
doi = "10.3389/fneur.2021.681413",
language = "English",
volume = "12",
journal = "Frontiers in Neurology",
issn = "1664-2295",
publisher = "Frontiers Research Foundation",

}

RIS

TY - JOUR

T1 - Vagus Nerve Cross-Sectional Area in Patients With Parkinson's Disease-An Ultrasound Case-Control Study

AU - Horsager, Jacob

AU - Walter, Uwe

AU - Fedorova, Tatyana D

AU - Andersen, Katrine B

AU - Skjærbæk, Casper

AU - Knudsen, Karoline

AU - Okkels, Niels

AU - von Weitzel-Mudersbach, Paul

AU - Dyrskog, Stig Eric

AU - Bergholt, Bo

AU - Borghammer, Per

N1 - Copyright © 2021 Horsager, Walter, Fedorova, Andersen, Skjærbæk, Knudsen, Okkels, von Weitzel-Mudersbach, Dyrskog, Bergholt and Borghammer.

PY - 2021/6

Y1 - 2021/6

N2 - Background: Vagal parasympathetic neurons are prone to degeneration in Parkinson's disease (PD). High-resolution ultrasound can precisely estimate the cross-sectional (CSA) area of peripheral nerves. Here, we tested the hypothesis that vagus CSA is reduced in PD. Methods: We included 56 healthy controls (HCs) and 63 patients with PD. Using a high-end ultrasound system equipped with a high-frequency transducer, five images were obtained of each nerve. The hypoechoic neuronal tissue was delineated offline with dedicated software and the CSA extracted. Results: In the initial PD vs. HC comparison, no statistically significant differences were observed in mean left vagus CSA (HC: 1.97 mm2, PD: 1.89 mm2, P = 0.36) nor in mean right vagus CSA (HC: 2.37 mm2, PD: 2.23 mm2, P = 0.17). The right vagus CSA was significantly larger than the left vagus CSA in both groups (P < 0.0001). Females were overrepresented in the HC group and presented with generally smaller vagus CSAs. Consequently, sex-adjusted CSA was significantly smaller for the right vagus nerve of the PD group (P = 0.041), but not for the left. Conclusion: A small but significant reduction in sex-adjusted right vagus CSA was observed in patients with PD. The left vagus CSA was not significantly reduced in patients with PD. Ultrasound may not be a suitable method to detecting vagal axonal loss in individual patients.

AB - Background: Vagal parasympathetic neurons are prone to degeneration in Parkinson's disease (PD). High-resolution ultrasound can precisely estimate the cross-sectional (CSA) area of peripheral nerves. Here, we tested the hypothesis that vagus CSA is reduced in PD. Methods: We included 56 healthy controls (HCs) and 63 patients with PD. Using a high-end ultrasound system equipped with a high-frequency transducer, five images were obtained of each nerve. The hypoechoic neuronal tissue was delineated offline with dedicated software and the CSA extracted. Results: In the initial PD vs. HC comparison, no statistically significant differences were observed in mean left vagus CSA (HC: 1.97 mm2, PD: 1.89 mm2, P = 0.36) nor in mean right vagus CSA (HC: 2.37 mm2, PD: 2.23 mm2, P = 0.17). The right vagus CSA was significantly larger than the left vagus CSA in both groups (P < 0.0001). Females were overrepresented in the HC group and presented with generally smaller vagus CSAs. Consequently, sex-adjusted CSA was significantly smaller for the right vagus nerve of the PD group (P = 0.041), but not for the left. Conclusion: A small but significant reduction in sex-adjusted right vagus CSA was observed in patients with PD. The left vagus CSA was not significantly reduced in patients with PD. Ultrasound may not be a suitable method to detecting vagal axonal loss in individual patients.

U2 - 10.3389/fneur.2021.681413

DO - 10.3389/fneur.2021.681413

M3 - Journal article

C2 - 34239497

VL - 12

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

M1 - 681413

ER -