Niels Okkels

Fasting gallbladder volume is increased in patients with Parkinson's disease

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Fasting gallbladder volume is increased in patients with Parkinson's disease. / Horsager, Jacob; Tiroke, Lasse Hubertus; Skjærbæk, Casper et al.

I: Parkinsonism & Related Disorders, Bind 87, 06.2021, s. 56-60.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Horsager, Jacob ; Tiroke, Lasse Hubertus ; Skjærbæk, Casper et al. / Fasting gallbladder volume is increased in patients with Parkinson's disease. I: Parkinsonism & Related Disorders. 2021 ; Bind 87. s. 56-60.

Bibtex

@article{d99552198e214ead9b4bdc3aa26ef40f,
title = "Fasting gallbladder volume is increased in patients with Parkinson's disease",
abstract = "INTRODUCTION: Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).METHODS: We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. fGBV was determined from abdominal CT scans, and radiopaque gallstone frequency was evaluated.RESULTS: Median fGBV was 35.7 ml in patients with PD, 31.8 ml in iRBD, and 27.8 ml in HCs (Kruskal-Wallis test: P = 0.0055). Post-tests adjusted for multiple comparison revealed a significant group difference between patients with PD and HCs (P = 0.0038). In the PD group, 23% had enlarged fGBV (cut-off at mean + 2 x standard deviation (SD) in the HC group). No difference in fGBV was observed between iRBD and the other two groups. The total prevalence of gallstones was 6.4% with no differences between the three groups.CONCLUSION: Almost a quarter of patients with PD in our cohort exhibited increased fGBV. This study illuminates a potentially overlooked topic in PD research and calls for more studies on biliary dysfunction.",
keywords = "Autonomic, CT, Gallbladder, Gallstone, Parkinson's disease",
author = "Jacob Horsager and Tiroke, {Lasse Hubertus} and Casper Skj{\ae}rb{\ae}k and Karoline Knudsen and Fedorova, {Tatyana D} and Niels Okkels and Per Borghammer",
year = "2021",
month = jun,
doi = "10.1016/j.parkreldis.2021.04.027",
language = "English",
volume = "87",
pages = "56--60",
journal = "Parkinsonism & Related Disorders",
issn = "1353-8020",
publisher = "Elsevier Ltd",

}

RIS

TY - JOUR

T1 - Fasting gallbladder volume is increased in patients with Parkinson's disease

AU - Horsager, Jacob

AU - Tiroke, Lasse Hubertus

AU - Skjærbæk, Casper

AU - Knudsen, Karoline

AU - Fedorova, Tatyana D

AU - Okkels, Niels

AU - Borghammer, Per

PY - 2021/6

Y1 - 2021/6

N2 - INTRODUCTION: Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).METHODS: We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. fGBV was determined from abdominal CT scans, and radiopaque gallstone frequency was evaluated.RESULTS: Median fGBV was 35.7 ml in patients with PD, 31.8 ml in iRBD, and 27.8 ml in HCs (Kruskal-Wallis test: P = 0.0055). Post-tests adjusted for multiple comparison revealed a significant group difference between patients with PD and HCs (P = 0.0038). In the PD group, 23% had enlarged fGBV (cut-off at mean + 2 x standard deviation (SD) in the HC group). No difference in fGBV was observed between iRBD and the other two groups. The total prevalence of gallstones was 6.4% with no differences between the three groups.CONCLUSION: Almost a quarter of patients with PD in our cohort exhibited increased fGBV. This study illuminates a potentially overlooked topic in PD research and calls for more studies on biliary dysfunction.

AB - INTRODUCTION: Autonomic denervation in patients with Parkinson's disease (PD) and isolated REM-sleep behavior disorder (iRBD) could impede gallbladder function leading to increased fasting gallbladder volume (fGBV) and higher risk of gallstones. We aimed to determine fGBV in patients with PD, iRBD, and healthy controls (HCs).METHODS: We included 189 subjects; 100 patients with PD, 21 with iRBD, and 68 HCs. fGBV was determined from abdominal CT scans, and radiopaque gallstone frequency was evaluated.RESULTS: Median fGBV was 35.7 ml in patients with PD, 31.8 ml in iRBD, and 27.8 ml in HCs (Kruskal-Wallis test: P = 0.0055). Post-tests adjusted for multiple comparison revealed a significant group difference between patients with PD and HCs (P = 0.0038). In the PD group, 23% had enlarged fGBV (cut-off at mean + 2 x standard deviation (SD) in the HC group). No difference in fGBV was observed between iRBD and the other two groups. The total prevalence of gallstones was 6.4% with no differences between the three groups.CONCLUSION: Almost a quarter of patients with PD in our cohort exhibited increased fGBV. This study illuminates a potentially overlooked topic in PD research and calls for more studies on biliary dysfunction.

KW - Autonomic

KW - CT

KW - Gallbladder

KW - Gallstone

KW - Parkinson's disease

UR - http://www.scopus.com/inward/record.url?scp=85105327127&partnerID=8YFLogxK

U2 - 10.1016/j.parkreldis.2021.04.027

DO - 10.1016/j.parkreldis.2021.04.027

M3 - Journal article

C2 - 33964787

VL - 87

SP - 56

EP - 60

JO - Parkinsonism & Related Disorders

JF - Parkinsonism & Related Disorders

SN - 1353-8020

ER -