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Niels Okkels
Disruption of Sleep Microarchitecture Is a Sensitive and Early Marker of Parkinson's Disease
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.3233/JPD-223442
Forlagets udgivne version
- Christopher E J Doppler, University of Cologne, Jülich Research Centre ,
- Julia Smit, University of Cologne ,
- Maximilian Hommelsen, Jülich Research Centre ,
- Aline Seger, University of Cologne, Jülich Research Centre ,
- Niels Okkels
- Jacob Horsager
- Martin Kinnerup
- Allan K Hansen
- Tatyana D Fedorova
- Karoline Knudsen ,
- Marit Otto
- Adjmal Nahimi
- Gereon R Fink, University of Cologne, Jülich Research Centre ,
- Per Borghammer
- Michael Sommerauer, Jülich Research Centre, University of Cologne
BACKGROUND: Although sleep disturbances are highly prevalent in patients with Parkinson's disease, sleep macroarchitecture metrics show only minor changes.
OBJECTIVE: To assess alterations of the cyclic alternating pattern (CAP) as a critical feature of sleep microarchitecture in patients with prodromal, recent, and established Parkinson's disease.
METHODS: We evaluated overnight polysomnography for classic sleep macroarchitecture and CAP metrics in 68 patients at various disease stages and compared results to 22 age- and sex-matched controls.
RESULTS: Already at the prodromal stage, patients showed a significantly reduced CAP rate as a central characteristic of sleep microarchitecture. Temporal characteristics of CAP showed a gradual change over disease stages and correlated with motor performance. In contrast, the sleep macroarchitecture metrics did not differ between groups.
CONCLUSION: Data suggest that alterations of sleep microarchitecture are an early and more sensitive characteristic of Parkinson's disease than changes in sleep macroarchitecture.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Parkinson's Disease |
| Vol/bind | 12 |
| Nummer | 8 |
| Sider (fra-til) | 2555-2560 |
| Antal sider | 6 |
| ISSN | 1877-7171 |
| DOI | |
| Status | Udgivet - dec. 2022 |
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