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Niels Okkels
[ 18F]FEOBV positron emission tomography may not be a suitable method to measure parasympathetic denervation in patients with Parkinson's disease.
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1016/j.parkreldis.2022.09.016
Forlagets udgivne version
- Jacob Horsager
- Niels Okkels
- Tatyana D Fedorova
- Karoline Knudsen, aDepartment of Infectious Diseases, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark bViro-Immunology Research Unit cDepartment of Clinical Immunology, Rigshospitalet, Copenhagen University Hospital, Copenhagen dDepartment of Clinical Immunology, Aarhus University Hospital, Aarhus eDepartment of Infectious Diseases, Hvidovre, Copenhagen University Hospital, Copenhagen fDepartment of Infectious Diseases, Odense University Hospital, Odense gDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark. ,
- Casper Skjærbæk
- Nathalie Van Den Berge
- Jan Jacobsen
- Ole Lajord Munk
- Erik Hvid Danielsen
- Dirk Bender
- David J Brooks
- Per Borghammer
INTRODUCTION: The peripheral autonomic nervous system may be involved years before onset of motor symptoms in some patients with Parkinson's disease (PD). Specific imaging techniques to quantify the cholinergic nervous system in peripheral organs are an unmet need. We tested the hypothesis that patients with PD display decreased [ 18F]FEOBV uptake in peripheral organs - a sign of parasympathetic denervation.
METHODS: We included 15 PD patients and 15 age- and sex matched healthy controls for a 70 min whole-body dynamic positron emission tomography (PET) acquisition. Compartmental modelling was used for tracer kinetic analyses of adrenal gland, pancreas, myocardium, spleen, renal cortex, muscle and colon. Standard uptake values (SUV) at 60-70 min post injection were also extracted for these organs. Additionally, SUVs were also determined in the total colon, prostate, parotid and submandibular glands.
RESULTS: We found no statistically significant difference of [ 18F]FEOBV binding parameters in any organs between patients with PD and healthy controls, although trends were observed. The pancreas SUV showed a 14% reduction in patients (P = 0.021, not statistically significant after multiple comparison correction). We observed a trend towards lower SUVs in the pancreas, colon, adrenal gland, and myocardium of PD patients with versus without probable REM sleep behavior disorder.
CONCLUSION: [ 18F]FEOBV PET may not be a sensitive marker for parasympathetic degeneration in patients with PD.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Parkinsonism & Related Disorders |
| Vol/bind | 104 |
| Sider (fra-til) | 21-25 |
| Antal sider | 5 |
| ISSN | 1353-8020 |
| DOI | |
| Status | E-pub ahead of print - 29 sep. 2022 |
Bibliografisk note
Copyright © 2022. Published by Elsevier Ltd.
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