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Niels Jessen

Growth hormone-induced insulin resistance in human subjects involves reduced pyruvate dehydrogenase activity

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Insulin resistance induced by growth hormone (GH) is linked to promotion of lipolysis by unknown mechanisms. We hypothesized that suppression of the activity of pyruvate dehydrogenase in the active form (PDHa) underlies GH-induced insulin resistance similar to what is observed during fasting.
OriginalsprogEngelsk
TidsskriftActa Physiologica (Print)
Vol/bind210
Nummer2
Sider (fra-til)392-402
Antal sider12
ISSN1748-1708
DOI
StatusUdgivet - 21 feb. 2014

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