Niels Jessen

Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue

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Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue. / Søndergaard, E; Gormsen, L C; Christensen, Mette Høgh; Pedersen, S B; Christiansen, P; Nielsen, Søren; Poulsen, P L; Jessen, N.

I: Diabetic medicine : a journal of the British Diabetic Association, Bind 32, Nr. 2, 32(2), 23.09.2014, s. e4-e8.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{7ec42451aa324c4dbee491ea2796e85e,
title = "Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue",
abstract = "BACKGROUND: Recruitment of brown adipose tissue is a promising strategy to treat obesity and Type 2 diabetes, but the physiological effects of a large amount of metabolically active brown adipose tissue in humans are unknown.CASE REPORT: In the present paper, we report a case of massive brown adipose tissue infiltration of the visceral adipose tissue depot in a person with Type 2 diabetes with a catecholamine-secreting paraganglioma. The patient was evaluated with [18F]-fludeoxyglucose positron emission tomography/computed tomography on three occasions: pre-therapy, during α-blockade and postoperatively. During surgery, biopsies of visceral and subcutaneous adipose tissue were obtained and evaluated for brown adipose tissue. At diagnosis, brown adipose tissue glucose uptake, assessed by [18F]-fludeoxyglucose-positron emission tomography, was massively increased. [18F]-fludeoxyglucose uptake was confined to known locations for brown adipose tissue, with additional uptake in the visceral adipose tissue. As a result of increased thermogenesis, resting energy expenditure was doubled. After surgical removal of the tumour, antidiabetic medicine was no longer needed, despite an 8.2-kg weight gain, CONCLUSION: These results show that human visceral adipose tissue holds an unprecedented potential for brown adipogenic differentiation; however, a detrimental effect on glucose metabolism persisted despite massive brown adipose tissue activity, with a doubling of resting energy expenditure. This article is protected by copyright. All rights reserved.",
author = "E S{\o}ndergaard and Gormsen, {L C} and Christensen, {Mette H{\o}gh} and Pedersen, {S B} and P Christiansen and S{\o}ren Nielsen and Poulsen, {P L} and N Jessen",
note = "This article is protected by copyright. All rights reserved.",
year = "2014",
month = sep,
day = "23",
doi = "10.1111/dme.12595",
language = "English",
volume = "32",
pages = "e4--e8",
journal = "Diabetic Medicine Online",
issn = "1464-5491",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "2",

}

RIS

TY - JOUR

T1 - Chronic adrenergic stimulation induces brown adipose tissue differentiation in visceral adipose tissue

AU - Søndergaard, E

AU - Gormsen, L C

AU - Christensen, Mette Høgh

AU - Pedersen, S B

AU - Christiansen, P

AU - Nielsen, Søren

AU - Poulsen, P L

AU - Jessen, N

N1 - This article is protected by copyright. All rights reserved.

PY - 2014/9/23

Y1 - 2014/9/23

N2 - BACKGROUND: Recruitment of brown adipose tissue is a promising strategy to treat obesity and Type 2 diabetes, but the physiological effects of a large amount of metabolically active brown adipose tissue in humans are unknown.CASE REPORT: In the present paper, we report a case of massive brown adipose tissue infiltration of the visceral adipose tissue depot in a person with Type 2 diabetes with a catecholamine-secreting paraganglioma. The patient was evaluated with [18F]-fludeoxyglucose positron emission tomography/computed tomography on three occasions: pre-therapy, during α-blockade and postoperatively. During surgery, biopsies of visceral and subcutaneous adipose tissue were obtained and evaluated for brown adipose tissue. At diagnosis, brown adipose tissue glucose uptake, assessed by [18F]-fludeoxyglucose-positron emission tomography, was massively increased. [18F]-fludeoxyglucose uptake was confined to known locations for brown adipose tissue, with additional uptake in the visceral adipose tissue. As a result of increased thermogenesis, resting energy expenditure was doubled. After surgical removal of the tumour, antidiabetic medicine was no longer needed, despite an 8.2-kg weight gain, CONCLUSION: These results show that human visceral adipose tissue holds an unprecedented potential for brown adipogenic differentiation; however, a detrimental effect on glucose metabolism persisted despite massive brown adipose tissue activity, with a doubling of resting energy expenditure. This article is protected by copyright. All rights reserved.

AB - BACKGROUND: Recruitment of brown adipose tissue is a promising strategy to treat obesity and Type 2 diabetes, but the physiological effects of a large amount of metabolically active brown adipose tissue in humans are unknown.CASE REPORT: In the present paper, we report a case of massive brown adipose tissue infiltration of the visceral adipose tissue depot in a person with Type 2 diabetes with a catecholamine-secreting paraganglioma. The patient was evaluated with [18F]-fludeoxyglucose positron emission tomography/computed tomography on three occasions: pre-therapy, during α-blockade and postoperatively. During surgery, biopsies of visceral and subcutaneous adipose tissue were obtained and evaluated for brown adipose tissue. At diagnosis, brown adipose tissue glucose uptake, assessed by [18F]-fludeoxyglucose-positron emission tomography, was massively increased. [18F]-fludeoxyglucose uptake was confined to known locations for brown adipose tissue, with additional uptake in the visceral adipose tissue. As a result of increased thermogenesis, resting energy expenditure was doubled. After surgical removal of the tumour, antidiabetic medicine was no longer needed, despite an 8.2-kg weight gain, CONCLUSION: These results show that human visceral adipose tissue holds an unprecedented potential for brown adipogenic differentiation; however, a detrimental effect on glucose metabolism persisted despite massive brown adipose tissue activity, with a doubling of resting energy expenditure. This article is protected by copyright. All rights reserved.

U2 - 10.1111/dme.12595

DO - 10.1111/dme.12595

M3 - Journal article

C2 - 25252000

VL - 32

SP - e4-e8

JO - Diabetic Medicine Online

JF - Diabetic Medicine Online

SN - 1464-5491

IS - 2

M1 - 32(2)

ER -