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Niels Henrik Ingvar Hjøllund

Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. / Jensen, T K; Henriksen, T B; Hjøllund, Niels Henrik Ingvar; Scheike, Thomas; Kolstad, Henrik; Giwercman, A; Ernst, E; Bonde, J P; Skakkebaek, N E; Olsen, J.

I: Reproductive Toxicology, Bind 12, Nr. 3, 1998, s. 289-95.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Jensen, TK, Henriksen, TB, Hjøllund, NHI, Scheike, T, Kolstad, H, Giwercman, A, Ernst, E, Bonde, JP, Skakkebaek, NE & Olsen, J 1998, 'Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy', Reproductive Toxicology, bind 12, nr. 3, s. 289-95.

APA

Jensen, T. K., Henriksen, T. B., Hjøllund, N. H. I., Scheike, T., Kolstad, H., Giwercman, A., Ernst, E., Bonde, J. P., Skakkebaek, N. E., & Olsen, J. (1998). Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reproductive Toxicology, 12(3), 289-95.

CBE

Jensen TK, Henriksen TB, Hjøllund NHI, Scheike T, Kolstad H, Giwercman A, Ernst E, Bonde JP, Skakkebaek NE, Olsen J. 1998. Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. Reproductive Toxicology. 12(3):289-95.

MLA

Vancouver

Author

Jensen, T K ; Henriksen, T B ; Hjøllund, Niels Henrik Ingvar ; Scheike, Thomas ; Kolstad, Henrik ; Giwercman, A ; Ernst, E ; Bonde, J P ; Skakkebaek, N E ; Olsen, J. / Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy. I: Reproductive Toxicology. 1998 ; Bind 12, Nr. 3. s. 289-95.

Bibtex

@article{6c4f2d68897e44e48362937a07298a94,
title = "Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy",
abstract = "Fecundability has been defined as the ability to achieve a recognized pregnancy. Several studies on caffeine and fecundability have been conducted but have been inconclusive. This may be explained partly by lack of stratification by smoking. Furthermore, few researchers have tried to separate the effect of caffeine from different sources (coffee, tea, cola, and chocolate). Clearly, the relationship between caffeine and fecundability needs further research, given the high prevalence of caffeine intake among women of childbearing age. We examined the independent and combined effects of smoking and caffeine intake from different sources on the probability of conception. From 1992 to 1995, a total of 430 couples were recruited after a nationwide mailing of a personal letter to 52,255 trade union members who were 20 to 35 years old, lived with a partner, and had no previous reproductive experience. At enrollment and in six cycles of follow-up, both partners filled out a questionnaire on different factors including smoking habits and their intake of coffee, tea, chocolate, cola beverages, and chocolate bars. In all, 1596 cycles and 423 couples were included in the analyses. The cycle-specific association between caffeine intake and fecundability was analyzed in a logistic regression model with the outcome at each cycle (pregnant or not pregnant) in a Cox discrete model calculating the fecundability odds-ratio (FR). Compared to nonsmoking women with caffeine intake less than 300 mg/d, nonsmoking women who consumed 300 to 700 mg/d caffeine had a FR of 0.88 [95% confidence interval (CI) 0.60-1.31], whereas women with a higher caffeine intake had a FR = 0.63 (95% CI 0.25-1.60) after adjusting for female body mass index and alcohol intake, diseases of the female reproductive organs, semen quality, and duration of menstrual cycle. No dose-response relationship was found among smokers. Among males, the same decline in point estimates of the FR was present. Smoking women whose only source of caffeine was coffee (>300 mg/d) had a reduced fecundability odds-ratio (FR = 0.34; 95% CI 0.12-0.98). An interaction between caffeine and smoking is biologically plausible, and the lack of effect among smokers may be due to faster metabolism of caffeine. Our findings suggest that especially nonsmoking women who wish to achieve a pregnancy might benefit from a reduced caffeine intake.",
keywords = "Adult, Caffeine, Denmark, Family Planning Services, Female, Fertility, Fertilization, Follow-Up Studies, Humans, Male, Odds Ratio, Pregnancy, Risk Factors, Smoking",
author = "Jensen, {T K} and Henriksen, {T B} and Hj{\o}llund, {Niels Henrik Ingvar} and Thomas Scheike and Henrik Kolstad and A Giwercman and E Ernst and Bonde, {J P} and Skakkebaek, {N E} and J Olsen",
year = "1998",
language = "English",
volume = "12",
pages = "289--95",
journal = "Reproductive Toxicology",
issn = "0890-6238",
publisher = "Elsevier Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Caffeine intake and fecundability: a follow-up study among 430 Danish couples planning their first pregnancy

AU - Jensen, T K

AU - Henriksen, T B

AU - Hjøllund, Niels Henrik Ingvar

AU - Scheike, Thomas

AU - Kolstad, Henrik

AU - Giwercman, A

AU - Ernst, E

AU - Bonde, J P

AU - Skakkebaek, N E

AU - Olsen, J

PY - 1998

Y1 - 1998

N2 - Fecundability has been defined as the ability to achieve a recognized pregnancy. Several studies on caffeine and fecundability have been conducted but have been inconclusive. This may be explained partly by lack of stratification by smoking. Furthermore, few researchers have tried to separate the effect of caffeine from different sources (coffee, tea, cola, and chocolate). Clearly, the relationship between caffeine and fecundability needs further research, given the high prevalence of caffeine intake among women of childbearing age. We examined the independent and combined effects of smoking and caffeine intake from different sources on the probability of conception. From 1992 to 1995, a total of 430 couples were recruited after a nationwide mailing of a personal letter to 52,255 trade union members who were 20 to 35 years old, lived with a partner, and had no previous reproductive experience. At enrollment and in six cycles of follow-up, both partners filled out a questionnaire on different factors including smoking habits and their intake of coffee, tea, chocolate, cola beverages, and chocolate bars. In all, 1596 cycles and 423 couples were included in the analyses. The cycle-specific association between caffeine intake and fecundability was analyzed in a logistic regression model with the outcome at each cycle (pregnant or not pregnant) in a Cox discrete model calculating the fecundability odds-ratio (FR). Compared to nonsmoking women with caffeine intake less than 300 mg/d, nonsmoking women who consumed 300 to 700 mg/d caffeine had a FR of 0.88 [95% confidence interval (CI) 0.60-1.31], whereas women with a higher caffeine intake had a FR = 0.63 (95% CI 0.25-1.60) after adjusting for female body mass index and alcohol intake, diseases of the female reproductive organs, semen quality, and duration of menstrual cycle. No dose-response relationship was found among smokers. Among males, the same decline in point estimates of the FR was present. Smoking women whose only source of caffeine was coffee (>300 mg/d) had a reduced fecundability odds-ratio (FR = 0.34; 95% CI 0.12-0.98). An interaction between caffeine and smoking is biologically plausible, and the lack of effect among smokers may be due to faster metabolism of caffeine. Our findings suggest that especially nonsmoking women who wish to achieve a pregnancy might benefit from a reduced caffeine intake.

AB - Fecundability has been defined as the ability to achieve a recognized pregnancy. Several studies on caffeine and fecundability have been conducted but have been inconclusive. This may be explained partly by lack of stratification by smoking. Furthermore, few researchers have tried to separate the effect of caffeine from different sources (coffee, tea, cola, and chocolate). Clearly, the relationship between caffeine and fecundability needs further research, given the high prevalence of caffeine intake among women of childbearing age. We examined the independent and combined effects of smoking and caffeine intake from different sources on the probability of conception. From 1992 to 1995, a total of 430 couples were recruited after a nationwide mailing of a personal letter to 52,255 trade union members who were 20 to 35 years old, lived with a partner, and had no previous reproductive experience. At enrollment and in six cycles of follow-up, both partners filled out a questionnaire on different factors including smoking habits and their intake of coffee, tea, chocolate, cola beverages, and chocolate bars. In all, 1596 cycles and 423 couples were included in the analyses. The cycle-specific association between caffeine intake and fecundability was analyzed in a logistic regression model with the outcome at each cycle (pregnant or not pregnant) in a Cox discrete model calculating the fecundability odds-ratio (FR). Compared to nonsmoking women with caffeine intake less than 300 mg/d, nonsmoking women who consumed 300 to 700 mg/d caffeine had a FR of 0.88 [95% confidence interval (CI) 0.60-1.31], whereas women with a higher caffeine intake had a FR = 0.63 (95% CI 0.25-1.60) after adjusting for female body mass index and alcohol intake, diseases of the female reproductive organs, semen quality, and duration of menstrual cycle. No dose-response relationship was found among smokers. Among males, the same decline in point estimates of the FR was present. Smoking women whose only source of caffeine was coffee (>300 mg/d) had a reduced fecundability odds-ratio (FR = 0.34; 95% CI 0.12-0.98). An interaction between caffeine and smoking is biologically plausible, and the lack of effect among smokers may be due to faster metabolism of caffeine. Our findings suggest that especially nonsmoking women who wish to achieve a pregnancy might benefit from a reduced caffeine intake.

KW - Adult

KW - Caffeine

KW - Denmark

KW - Family Planning Services

KW - Female

KW - Fertility

KW - Fertilization

KW - Follow-Up Studies

KW - Humans

KW - Male

KW - Odds Ratio

KW - Pregnancy

KW - Risk Factors

KW - Smoking

M3 - Journal article

C2 - 9628552

VL - 12

SP - 289

EP - 295

JO - Reproductive Toxicology

JF - Reproductive Toxicology

SN - 0890-6238

IS - 3

ER -