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Niels Henrik Ingvar Hjøllund

Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of Conception

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Background: Animal studies indicate that some phthalate metabolites may harm female reproductive function. Objectives: We assessed the associations between exposure to phthalate metabolites and pregnancy loss. Methods: In a previously established cohort of first pregnancy planners, we analyzed four primary and two oxidized secondary phthalate metabolites in urine samples collected on day 10 after the first day of the last menstrual period before conception occurred (n=128) and during the previous cycle (if any, n=111). Subclinical embryonal loss was identified by repeated urinary hCG measurements and information on clinical spontaneous abortions was obtained by telephone interview with the mother. Results. Pregnancy loss (n = 48) was increased among women with urinary concentration of monoethylhexyl phthalate (MEHP) in the upper tertile in the conception sample compared with women in the lowest tertile [adjusted odds ratio 2.9; 95% confidence interval (CI) 1.1; 7.6]. The corresponding odds ratio for subclinical embryonal loss (n=32) was 40.7 (CI 4.5; 369.5). Conclusions. The phthalate metabolite MEHP was associated with higher occurrence of pregnancy loss. Since this is the first human study to show this association and the sample size is small, the findings need to be corroborated in independent studies.
TidsskriftEnvironmental Health Perspectives
StatusUdgivet - 2011

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