Nicolaj Støttrup

Remote ischemic preconditioning with - but not without - metabolic support protects the neonatal porcine heart against ischemia-reperfusion injury

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Michael R Schmidt, Danmark
  • Nicolaj B Støttrup
  • Hussain Contractor
  • ,
  • Janus A Hyldebrandt, Danmark
  • Mogens Johannsen
  • Christian M Pedersen, Danmark
  • Rune Birkler, Danmark
  • Houman Ashrafian
  • ,
  • Keld E Sørensen, Danmark
  • Rajesh K Kharbanda
  • ,
  • Andrew N Redington
  • ,
  • Hans E Bøtker
While remote ischemic preconditioning (rIPC) protects the mature heart against ischemia-reperfusion (IR) injury, the effect on the neonatal heart is not known. The neonatal heart relies almost solely on carbohydrate metabolism, which is modified by rIPC in the mature heart. We hypothesized that rIPC combined with metabolic support with glucose-insulin (GI) infusion improves cardiac function and reduces infarct size after IR injury in neonatal piglets in-vivo.
OriginalsprogEngelsk
TidsskriftInternational Journal of Cardiology
ISSN0167-5273
DOI
StatusUdgivet - 12 nov. 2013

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