Department of Biomedicine

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Morten Schallburg Nielsen

Cand Scient, PhD, Professor, Affiliated Researcher

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Morten Schallburg Nielsen

Professor, Affiliated Researcher

  • Institut for Biomedicin - Forskning og uddannelse, Skou-bygningen
  • DANDRITE
Postaddresse:
Høegh-Guldbergs Gade 10
1116, 246
8000
Aarhus C
Danmark
Postaddresse:
Høegh-Guldbergsgade 10
8000
Aarhus C
Danmark

E-mail: mn@biomed.au.dk

Mobil: +4528992387

Telefon: +4528992387

Curriculum Vitae

Research networks and centres

Neuroscience at Institute of Biomedicine

Research Initiative on Brain Barriers and Drug Delivery - RIBBDD

IM2PACT - Horizon2020/IMI2 project 

Employments

1997-1998    Post. Doc., Department of Medical Biochemistry, Aarhus University

1998-2001    Assistant professor, Department of Medical Biochemistry, Aarhus University

2001-2011    Associated professor, Department of Medical Biochemistry, Aarhus University

2011-            Associated professor msk, Department of Biomedicine, Aarhus University

2019-           Director of Imaging Core Facility, Health, Aarhus University

Educational degrees

1993            Master in Chemistry and Biotechnology, Faculty of Science, Aarhus University 

1998            PhD degree, Faculty of Health Science, Aarhus University 

 

Work in foreign laboratories 

2001    3 month at Münster University, Germany, Institut für Physiologische Chemie und Pathobiochemie.

2001    6 month at Nice University, France, Institut de Pharmacologie Moléculaire et Cellulaire, i

2010    6 weeks at Oslo University, Norway, Department of Molecular Biosciences.

Boards and appointments

Editorial boards of Membranes since 2011 and International Journal of Molecular Sciences since 2018

Member of Aarhus University election committee since 2014

Management committee of Danish Society of Bioimaging since 2016

 

Founding

1994 Kong Chr. X's Fond 10.000 DKK

1998 Statens sundhedsvidenskabelige forskningsråd 1.360.800 DKK

2001 Statens sundhedsvidenskabelige forskningsråd   80.730 DKK

2001 Novo Fonden 80.000 DKK

2001 Aarhus Universitets Forskningsfond  187.000 DKK

2002 Carlsbergfondet 158.200 DKK

2004 Statens sundhedsvidenskabelige forskningsråd  200.000 DKK

2007 Aarhus Universitets Forskningsfond 187.300 DKK

2011 Lundbeckfonden* 2.000.000 DKK

2011 Lundbeckfonden 450.000 DKK

2011 Lundbeckfonden 1.100.000 DKK

2012 Dagmar Marshalls Fond 75.000 DKK

2014 Lundbeckfonden* 40.000.000 DKK

2015 Mejeribrugets forskningsfond* 1.856.000 DKK

2015 Membranes  60.000 DKK

2015 Parkinsonfonden 150.000 DKK

2016 Fonden til lægevidenskabens fremme 40.000 DKK

2016 H. Lundbeck A/S 500.000 DKK

2017 Lundbeckfonden* 20.000.000 DKK

2017 Rissfort Fonden  300.000 DKK

2017 Novo fonden* 2.998.212 DKK

2018 Horizon2020 IMI Call 12 topic 6* 9.000.000 €

2018 Simon Fougner Hartmann’s fond  440.000 DKK 

2018 Lundbeckfonden* 24.000.000 DKK

*Co-applicant

Publikationer

Apicobasal transferrin receptor localization and trafficking in brain capillary endothelial cells

Nielsen, S. S. E., Holst, M. R., Langthaler, K., Bruun, E. H., Brodin, B. & Nielsen, M. S., dec. 2023, I: Fluids and Barriers of the CNS. 20, 1, 15 s., 2.

Modelling a Human Blood-Brain Barrier Co-Culture Using an Ultrathin Silicon Nitride Membrane-Based Microfluidic Device

Hudecz, D., McCloskey, M. C., Vergo, S., Christensen, S., McGrath, J. L. & Nielsen, M. S., mar. 2023, I: International Journal of Molecular Sciences . 24, 6, 5624.

Sortilins in the blood-brain barrier: impact on barrier integrity

Toth, A. E. & Nielsen, M. S., mar. 2023, I: Neural Regeneration Research. 18, 3, s. 549-550 2 s.

SorLA in astrocytes regulates blood-brain barrier integrity

Toth, A. E., Klepe, A., Lipka, D. V., Goldeman, C., Brodin, B. & Nielsen, M. S., 5 jan. 2023, I: Frontiers in Drug Delivery.

Sortilin regulates blood-brain barrier integrity

Toth, A. E., Helms, H. C., Harazin, A., Johnsen, K. B., Goldeman, C., Burkhart, A., Thomsen, M. S., Kempen, P. J., Klepe, A., Lipka, D. V., Møller, P. L., Andresen, T. L., Nyegaard, M., Moos, T., Brodin, B. & Nielsen, M. S., feb. 2022, I: The FEBS Journal. 289, 4, s. 1062-1079 18 s.

Polarized α-synuclein trafficking and transcytosis across brain endothelial cells via Rab7-decorated carriers

Alam, P., Holst, M. R., Lauritsen, L., Nielsen, J., Nielsen, S. S. E., Jensen, P. H., Brewer, J. R., Otzen, D. E. & Nielsen, M. S., 2022, I: Fluids and Barriers of the CNS. 19, 1, 12 s., 37.

Basigin Antibodies with Capacity for Drug Delivery Across Brain Endothelial Cells

Christensen, S. C., Hudecz, D., Jensen, A., Christensen, S. & Nielsen, M. S., sep. 2021, I: Molecular Neurobiology. 58, 9, s. 4392-4403 12 s.

Cyclic hypoxia conditioning alters the content of myoblast-derived extracellular vesicles and enhances their cell-protective functions

Yan, Y., Gu, T., Christensen, S. D. K., Su, J., Lassen, T. R., Hjortbak, M. V., Lo, I., Venø, S. T., Tóth, A. E., Song, P., Nielsen, M. S., Bøtker, H. E., Blagoev, B., Drasbek, K. R. & Kjems, J., sep. 2021, I: Biomedicines. 9, 9, 20 s., 1211.

Two peptides targeting endothelial receptors are internalized into murine brain endothelial cells

Hudecz, D., Sigurdardóttir, S. B., Christensen, S. C., Hempel, C., Urquhart, A. J., Andresen, T. L. & Nielsen, M. S., apr. 2021, I: PLOS ONE. 16, 4 , 20 s., e0249686.

Mapping Receptor Antibody Endocytosis and Trafficking in Brain Endothelial Cells

Holst, M. R., Nielsen, S. S. E. & Nielsen, M. S., 2021, Permeability Barrier: Methods and Protocols. 2. udg. Springer, s. 193-205 13 s. (Methods in molecular biology (Clifton, N.J.), Bind 2367).

Transport of a peptide from bovine αs1-casein across models of the intestinal and blood–brain barriers

Christensen, B., Toth, A. E., Nielsen, S. S. E., Scavenius, C., Petersen, S. V., Enghild, J. J., Rasmussen, J. T., Nielsen, M. S. & Sørensen, E. S., okt. 2020, I: Nutrients. 12, 10, 14 s., 3157.

Maternally contributed Nlrp9b expressed in human and mouse ovarian follicles contributes to early murine preimplantation development

Amoushahi, M., Steffensen, L. L., Galieva, A., Agger, J., Heuck, A., Siupka, P., Ernst, E., Nielsen, M. S., Sunde, L. & Lykke-Hartmann, K., jun. 2020, I: Journal of Assisted Reproduction and Genetics. 37, 6, s. 1355-1365 11 s.

Ultrathin Silicon Membranes for in Situ Optical Analysis of Nanoparticle Translocation across a Human Blood-Brain Barrier Model

Hudecz, D., Khire, T., Chung, H. L., Adumeau, L., Glavin, D., Luke, E., Nielsen, M. S., Dawson, K. A., McGrath, J. L. & Yan, Y., jan. 2020, I: ACS Nano. 14, 1, s. 1111-1122 12 s.

Characterization of basigin monoclonal antibodies for receptor-mediated drug delivery to the brain

Christensen, S. C., Krogh, B. O., Jensen, A., Andersen, C. B. F., Christensen, S. & Nielsen, M. S., 2020, I: Scientific Reports. 10, 1, 13 s., 14582.

Conjugation of Therapeutic PSD-95 Inhibitors to the Cell-Penetrating Peptide Tat Affects Blood-Brain Barrier Adherence, Uptake, and Permeation

Kristensen, M., Kucharz, K., Felipe Alves Fernandes, E., Strømgaard, K., Schallburg Nielsen, M., Cederberg Helms, H. C., Bach, A., Ulrikkaholm Tofte-Hansen, M., Irene Aldana Garcia, B., Lauritzen, M. & Brodin, B., 2020, I: Pharmaceutics. 12, 7, s. 1-24 24 s., 661.

Vesicular Transport Machinery in Brain Endothelial Cells: What We Know and What We Do Not

Toth, A. E., Holst, M. R. & Nielsen, M. S., 2020, I: Current Pharmaceutical Design. 26, 13, s. 1405-1416 12 s.

The endo-lysosomal system of bEnd.3 and hCMEC/D3 brain endothelial cells

Toth, A. E., Nielsen, S. S. E., Tomaka, W., Abbott, N. J. & Nielsen, M. S., maj 2019, I: Fluids and Barriers of the CNS. 16, 14.

HSPA12A targets the cytoplasmic domain and affects the trafficking of the Amyloid Precursor Protein receptor SorLA

Madsen, P., Isaksen, T. J., Siupka, P., Tóth, A. E., Nyegaard, M., Gustafsen, C. & Nielsen, M. S., 2019, I: Scientific Reports. 9, 13 s., 611.

The effect of hypoxia on ZEB1 expression in a mimetic system of the blood-brain barrier

Leduc-Galindo, D., Qvist, P., Tóth, A. E., Fryland, T., Nielsen, M. S., Børglum, A. D. & Christensen, J. H., 2019, I: Microvascular Research. 122, s. 131-135 5 s.

The Endo-Lysosomal System of Brain Endothelial Cells Is Influenced by Astrocytes In Vitro

Toth, A. E., Siupka, P., P Augustine, T. J., Venø, S. T., Thomsen, L. B., Moos, T., Lohi, H. T., Madsen, P., Lykke-Hartmann, K. & Nielsen, M. S., nov. 2018, I: Molecular Neurobiology. 55, 11, s. 8522-8537 16 s.

Analysis of the trafficking system in blood-brain barrier models by high content screening microscopy

Tóth, A. & Nielsen, M. S., 12 sep. 2018, I: Neural Regeneration Research. 13, 11, s. 1883 1884 s.

Biochemical and cognitive effects of docosahexaenoic acid differ in a developmental and SorLA dependent manner

Højland, A., Richner, M., Mølgaard, S., Dieu, R. S., Eskelund, A., Nykjær, A., Nyengaard, J. R., Lykkesfeldt, J., Glerup, S. & Nielsen, M. S., 1 aug. 2018, I: Behavioural Brain Research. 348, s. 90-100 11 s.

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles

Johnsen, K. B., Bak, M., Kempen, P. J., Melander, F., Burkhart, A., Thomsen, M. S., Nielsen, M. S., Moos, T. & Andresen, T. L., 2018, I: Theranostics. 8, 12, s. 3416-3436 21 s.

Improved Method for the Establishment of an In Vitro Blood-Brain Barrier Model Based on Porcine Brain Endothelial Cells

Nielsen, S. S. E., Siupka, P., Georgian, A., Preston, J. E., Tóth, A. E., Yusof, S. R., Abbott, N. J. & Nielsen, M. S., 24 sep. 2017, I: Journal of Visualized Experiments. 127

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma

Johnsen, K. B., Burkhart, A., Melander, F., Kempen, P. J., Vejlebo, J. B., Siupka, P., Nielsen, M. S., Andresen, T. L. & Moos, T., 4 sep. 2017, I: Scientific Reports. 7, 1, s. 10396

Bidirectional apical-basal traffic of the cation-independent mannose-6-phosphate receptor in brain endothelial cells

Siupka, P., Hersom, M. N., Lykke-Hartmann, K., Johnsen, K. B., Thomsen, L. B., Andresen, T. L., Moos, T., Abbott, N. J., Brodin, B. & Nielsen, M. S., 2017, I: Journal of Cerebral Blood Flow and Metabolism. 37, 7, 16 s., 271678X17700665.

Maternally Contributed Folate Receptor 1 Is Expressed in Ovarian Follicles and Contributes to Preimplantation Development

Strandgaard, T., Foder, S., Heuck, A., Ernst, E., Nielsen, M. S. & Lykke-Hartmann, K., 2017, I: Frontiers in Cell and Developmental Biology. 5, 11 s., 89.

Transferrin receptor expression and role in transendothelial transport of transferrin in cultured brain endothelial monolayers

Hersom, M., Helms, H. C., Pretzer, N., Goldeman, C., Jensen, A. I., Severin, G., Nielsen, M. S., Holm, R. & Brodin, B., 1 okt. 2016, I: Molecular and Cellular Neuroscience. 76, s. 59-67 9 s.

Aldehyder og ketoner

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Alkener, alkyner og isomeri

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Alkoholer, phenoler, ethere og thioler

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Aminer og amider

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Bindinger og molekylestruktur

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Carboxylsyrer og carboxylsyrederivater

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Energetik

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Intermolekylære bindinger og tilstandsformer

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Kemisk Ligevægt

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Kulhydrater

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Lipider

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Molekylestruktur og fysisk-kemiske egenskaber

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Nukleotider og nukleoinsyrer

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Periodesystem og støkiometri

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Reaktionskinitik og katalyse

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk kemi. Systime

Reduktorer og oxidatorer

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Syrer og baser

Andersen, O. M., Nielsen, M. S. & Vægter, C. B., 25 aug. 2016, Medicinsk Kemi. Systime

Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease

Matrone, C., Dzamko, N., Madsen, P., Nyegaard, M., Pohlmann, R., Søndergaard, R. V., Lassen, L. B., Andresen, T. L., Halliday, G. M., Jensen, P. H. & Nielsen, M. S., 10 aug. 2016, I: PLOS ONE. 11, 8, s. e0160501

Polarized Trafficking of the Sorting Receptor SorLA in Neurons and MDCK Cells

Klinger, S. C., Højland, A., Jain, S., Kjolby, M., Madsen, P., Svendsen, A. D., Olivecrona, G., Bonifacino, J. S. & Nielsen, M. S., 18 maj 2016, I: F E B S Journal. 283, 13, s. 2476–2493

Cytokine-like factor-1 (CLF-1): An essential facilitator of cardiotrophin-like cytokine: CNTFRα (CLC:CNTFRα) signalling and sorLA mediated turnover

Larsen, J. V., Kristensen, A. M., Pallesen, L. T., Bauer, J., Vægter, C. B., Nielsen, M. S., Madsen, P. & Petersen, C. M., 2016, I: Molecular and Cellular Biology.

Expression of Iron-Related Proteins at the Neurovascular Unit Supports Reduction and Reoxidation of Iron for Transport Through the Blood-Brain Barrier

Burkhart, A., Skjørringe, T., Johnsen, K. B., Siupka, P., Thomsen, L. B., Nielsen, M. S., Thomsen, L. L. & Moos, T., 21 dec. 2015, I: Molecular Neurobiology.

A Novel Locus Harbouring a Functional CD164 Nonsense Mutation Identified in a Large Danish Family with Nonsyndromic Hearing Impairment

Nyegaard, M., Rendtorff, N. D., Nielsen, M. S., Corydon, T. J., Demontis, D., Starnawska, A., Hedemand, A., Buniello, A., Niola, F., Overgaard, M. T., Leal, S. M., Ahmad, W., Wikman, F. P., Petersen, K. B., Crüger, D. G., Oostrik, J., Kremer, H., Tommerup, N., Frödin, M., Steel, K. P., Tranebjærg, L. & Børglum, A. D., jul. 2015, I: P L o S Genetics. 11, 7, s. e1005386

Sortilin, encoded by the cardiovascular risk gene SORT1, and its suggested functions in cardiovascular disease

Kjolby, M., Nielsen, M. S. & Petersen, C. M., apr. 2015, I: Current Atherosclerosis Reports. 17, 4, s. 496

Retromer-Mediated Trafficking of Transmembrane Receptors and Transporters

Klinger, S. C., Siupka, P. & Nielsen, M. S., 2015, I: Membranes. 5, 3, s. 288-306 19 s.

Y682G Mutation of Amyloid Precursor Protein Promotes Endo-Lysosomal Dysfunction by Disrupting APP-SorLA Interaction

La Rosa, L. R., Perrone, L., Nielsen, M. S., Calissano, P., Andersen, O. M. & Matrone, C., 2015, I: Frontiers in Cellular Neuroscience. 9, s. 109

The Pro-Neurotrophin Receptor Sortilin Is a Major Neuronal Apolipoprotein E Receptor for Catabolism of Amyloid-β Peptide in the Brain

Carlo, A-S., Gustafsen, C., Mastrobuoni, G., Nielsen, M. S., Burgert, T., Hartl, D., Rohe, M., Nykjaer, A., Herz, J., Heeren, J., Kempa, S., Petersen, C. M. & Willnow, T. E., 2013, I: Journal of Neuroscience. 33, 1, s. 358-70 13 s.

SorLA regulates trafficking of Lipoprotein Lipase in polarized cells and astrocytes

Klinger, S. C., Højland, A., Gustafsen, C., Glerup, S., Kjølby, M. F., Helms, H. C., Raarup, M. K., Olivecrona, G., Brodin, B., Petersen, C. M., Nykjær, A. & Nielsen, M. S., 15 jun. 2012.

The C-terminal proteolytic processing of extracellular superoxide dismutase is redox regulated

Gottfredsen, R. H., Tran, S. M-H., Larsen, U. G., Madsen, P., Nielsen, M. S., Enghild, J. J. & Petersen, S. V., 1 jan. 2012, I: Free Radical Biology & Medicine. 52, 1, s. 191-197 7 s.

Dynamics of Rab7b-dependent transport of sorting receptors

Progida, C., Nielsen, M. S., Koster, G., Bucci, C. & Bakke, O., 2012, I: Traffic. 13, 9, s. 1273–1285

SorLA regulates the activity of lipoprotein lipase by intracellular trafficking

Klinger, S. C., Glerup, S., Raarup, M. K., Mari, M. C., Nyegaard, M., Koster, G., Prabakaran, T., Nilsson, B. S., Kjaergaard, M. M., Bakke, O., Nykjær, A., Olivecrona, G., Petersen, C. M. & Nielsen, M. S., 2011, I: Journal of Cell Science. 124, Pt 7, s. 1095-105 11 s.

Sortilin Facilitates Signaling of Ciliary Neurotrophic Factor and Related Helical Type 1 Cytokines Targeting the gp130/Leukemia Inhibitory Factor Receptor β Heteromer

Larsen, J. V., Hansen, M., Møller, B. K., Madsen, P. S., Scheller, J., Nielsen, M. S. & Petersen, C. M., 2010, I: Molecular and Cellular Biology. 30, 17, s. 4175-4187

The concentration of extracellular superoxide dismutase in plasma is maintained by LRP-mediated endocytosis

Petersen, S. V., Thøgersen, I., Valnickova, Z., Nielsen, M. S., Petersen, J. S., Poulsen, E. T., Jacobsen, C., Oury, T. D., Moestrup, S. K., Crapo, J. D., Nielsen, N. C., Kristensen, T. & Enghild, J. J., 2010, I: Free Radical Biology & Medicine. 49, 5, s. 894-9 5 s.

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families

Nilsson, S. K., Klinger, S. C., Raarup, M. K., Ryan, R., Nielsen, M. S. & Olivecrona, G., 19 sep. 2008, I: Journal of Cell Science.

Different motifs regulate trafficking of SorCS1 isoforms

Nielsen, M. S., Keat, S. J., Hamati, J. W., Madsen, P., Gutzmann, J. J., Engelsberg, A., Pedersen, K-M., Gustafsen, C., Nykjaer, A., Gliemann, J., Hermans-Borgmeyer, I., Kuhl, D., Petersen, C. M. & Hermey, G., 2008, I: Traffic. 9, 6, s. 980-94 15 s.

Endocytosis of apolipoprotein A-V by members of the low density lipoprotein receptor and the VPS10p domain receptor families

Nilsson, S. K., Christensen, S., Raarup, M. K., Ryan, R. O., Nielsen, M. S. & Olivecrona, G., 2008, I: Journal of Biological Chemistry. 283, 38, s. 25920-7 7 s.

Interactions Between Sortilin And Class-I Helical Cytokines

Larsen, J. V., Nielsen, M. S., Møller, B. K., Madsen, P. & Petersen, C. M., 2008.

Using FRET in the study of the Vps10pD receptors: Annual Meeting of the Nordic Microscopy Society (Scandem)

Kjærgaard, M., Skeldal, S., Raarup, M. K., Nykjær, A., Nyengaard, J. R. & Nielsen, M. S., 2008

Sorting by the cytoplasmic domain of the amyloid precursor protein binding receptor SorLA.

Nielsen, M. S., Gustafsen, C., Madsen, P., Nyengaard, J. R., Hermey, G., Bakke, O., Mari, M., Schu, P., Pohlmann, R., Dennes, A. & Petersen, C. M., 2007, I: Molecular and Cellular Biology. 27, 19, s. 6842-51 9 s.

The APP binding receptor SorLA mediates Golgi-endosome shuttling

Gustafsen, C., Nielsen, M. S., Madsen, P. S., Dennes, A., Schu, P. & Petersen, C. M., 2006.

Erratum: SorCS3 does not require propeptide cleavage to bind nerve growth factor (FEBS 29259) (FEBS Letters (2005) 579 (1172-1176)) DOI: 10.1016/j.febslet.2004.12.088

Westergaard, U. B., Kirkegaard, K., Sørensen, E. S., Jacobsen, C., Nielsen, M. S., Petersen, C. M. & Madsen, P., 9 maj 2005, I: FEBS Letters. 579, 12, 1 s.

SorCS3 does not require propeptide cleavage to bind nerve growth factor

Westergaard, U. B., Kirkegaard, K., Sørensen, E. S., Jacobsen, C., Nielsen, M. S., Pedersen, J. C. M. & Madsen, P. S., 2005, I: F E B S Letters. 579, 5, s. 1172-1176 5 s.

Functional organization of the sortilin Vps10p domain

Westergaard, U. B., Sørensen, E. S., Hermey, G., Nielsen, M. S., Nykjær, A., Kirkegaard, K., Jacobsen, C., Gliemann, J., Madsen, P. S. & Pedersen, J. C. M., 2004, I: Journal of Biological Chemistry. 279, s. 50221-50229 9 s.

Sortilin is essential for proNGF-induced neuronal cell death

Nykjær, A., Lee, R., Teng, K. K., Jansen, P., Madsen, P. S., Nielsen, M. S., Jacobsen, C., Kliemannel, M., Schwarz, E., Willnow, T. E., Hempstead, B. L. & Pedersen, J. C. M., 2004, I: Nature. 427, s. 843-848 6 s.

Distribution of NTS3 receptor/sortilin mRNA and protein in the rat central nervous system

Sarret, P., Krzykowski, P., Segal, L., Nielsen, M. S., Pedersen, J. C. M., Mazella, J., Stroh, T. & Beaudet, A., 2003, I: J. Comp. Neurol.. 461, s. 483-505 23 s.

Caspase-mediated parkin cleavage in apoptotic cell death

Kahns, S., Lykkebo, S., Jakobsen, L. D., Nielsen, M. S. & Jensen, P. H., 2002, I: Journal of Biological Chemistry. 277, s. 15303-15308 6 s.

The Yeast Vps10p Cytoplasmic Tail Mediates Lysosomal Sorting in Mammalian Cells and Interacts with Human GGAs

Dennes, A., Madsen, P. S., Nielsen, M. S., Pedersen, J. C. M. & Pohlmann, R., 2002, I: Journal of Biological Chemistry. 277, 14, s. 12288-12293 6 s.

The sorLA cytoplasmic domain interacts with GGA1 and -2 and defines minimum requirements for GGA binding

Jacobsen, L., Madsen, P. S., Nielsen, M. S., Geraerts, W. P. M., Gliemann, J., Smit, A. B. & Pedersen, J. C. M., 2002, I: F E B S Letters. 511, 1-3, s. 155-158 4 s.

Activation and functional characterization of the mosaic receptor SorLA/LR11

Jacobsen, L., Madsen, P., Jacobsen, C., Nielsen, M. S., Gliemann, J. & Petersen, C. M., 2001, I: Journal of Biological Chemistry. 276, s. 22788-22796 9 s.

Ca2+ binding to α-synuclein regulates ligand binding and oligomerization

Nielsen, M. S., Vorum, H., Lindersson, E. & Jensen, P. H., 2001, I: Journal of Biological Chemistry. 276, s. 22680-22684 5 s.

Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3)

Nykjær, A., Fyfe, J. C., Kozyraki, R., Leheste, J. R., Jacobsen, C., Nielsen, M. S., Verroust, P. J., Aminoff, M., de la Chapelle, A., Moestrup, S. K., Ray, R., Gliemann, J., Willnow, T. E. & Christensen, E. I., 2001, I: Proceedings of the National Academy of Sciences. 98, s. 13895-13900 6 s.

Pharmacological properties of the mouse neurotensin receptor 3. Maintenance of cell surface receptor during internalization of neurotensin

Navarro, V., Martin, S., Sarret, P., Nielsen, M. S., Pedersen, J. C. M., Vincent, J-P. & Mazella, J., 2001, I: F E B S Letters. 495, s. 100-105 6 s.

The sortilin cytoplasmic tail conveys Golgi-endosome transport and binds the VHS domain of the GGA2 sorting protein

Nielsen, M. S., Madsen, P. S., Christensen, E. I., Nykjær, A., Gliemann, J., Kasper, D., Pohlmann, R. & Pedersen, J. C. M., 2001, I: E M B O Journal. 20, s. 2180-2190 11 s.

Contribution of the carboxyl-terminal domain of lipoprotein lipase to interaction with heparin and lipoproteins

Lookene, A., Nielsen, M. S., Gliemann, J. & Olivecrona, G., 2000, I: Biochem. Biophys. Res. Commun.. 271, s. 15-21 7 s.

Microtubule-associated protein 1B is a component of cortical lewy bodies

Jensen, P. H., Islam, K., Kenney, J., Nielsen, M. S., Power, J. & Gai, W. P., 2000, I: Journal of Biological Chemistry. 275, s. 21500-21507 8 s.

Trichosanthin interacts with and enters cells via LDL receptor family members

Chan, W. L., Shaw, P. C., Tam, S. C., Jacobsen, C., Gliemann, J. & Nielsen, M. S., 2000, I: Biochem. Biophys. Res. Commun.. 270, s. 453-457 4 s.

Alpha-synuclein binds TAU and stimulates the protein kinase A-catalyzed TAU phosphorylation of serine residues 261 and 356

Jensen, P. H., Hager, H., Nielsen, M. S., Højrup, P., Gliemann, J. & Jakes, R., 1999, I: Journal of Biological Chemistry. 274, s. 25481-25489 9 s.

Propeptide cleavage conditions sortilin/neurotensin receptor-3 for ligand binding

Petersen, C. M., Nielsen, M. S., Jacobsen, C., Tauris, J., Jacobsen, L., Gliemann, J., Moestrup, S. K. & Madsen, P. S., 1999, I: E M B O Journal. 18, s. 595-604 10 s.

Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase

Nielsen, M. S., Jacobsen, C., Olivecrona, G., Gliemann, J. & Petersen, C. M., 1999, I: Journal of Biological Chemistry. 274, s. 8832-8836 5 s.

Urokinase-type plasminogen activator (uPAR) is internalized by different mechanisms in polarized and nonpolarized MDCK epithelial cells

Wilhardt, F., Nielsen, M. S., Sandvig, K. & van Deurs, B., 1999, I: Mol. Biol. Cell. 10, s. 179-195 16 s.

Binding of α-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation

Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G. & Goedert, M., 9 okt. 1998, I: Journal of Biological Chemistry. 273, 41, s. 26292-26294 3 s.

Binding of alpha-synuclein to brain vesicles is abolished by familial Parkinson's disease mutation

Jensen, P. H., Nielsen, M. S., Jakes, R., Dotti, C. G. & Goedert, M., 1998, I: J Biol Chem Commun. 273, s. 26292-26294 3 s.

Characterization of a kidney proximal tubule cell line, LLCPK1, expressing endocytotic active megalin

Nielsen, R., Birn, H., Moestrup, S. K., Nielsen, M. S., Verroust, P. & Christensen, E. I., 1998, I: Journal of the American Society of Nephrology. 9, s. 1767-1776

The carboxy-terminal domain of the receptor-associated protein binds to the Vps10p domain of sortilin

Tauris, J., Ellgaard, L., Jacobsen, C., Nielsen, M. S., Madsen, P. S., Thøgersen, H. C., Gliemann, J., Petersen, C. M. & Moestrup, S. K., 1998, I: F E B S Letters. 429, 1, s. 27-30

Binding of Aβ to α- and β-synucleins: Identification of segments in α-synuclein/NAC precursor that bind Aβ and NAC

Jensen, P. H., Højrup, P., Hager, H., Nielsen, M. S., Jacobsen, L., Olesen, O. F., Gliemann, J. & Jakes, R., 1997, I: Biochem. J.. 323, s. 539-546 8 s.

Expression of tissue transglutaminase in human bladder carcinoma

Hager, H., Jensen, P. H., Hamilton-Dutoit, S. J., Nielsen, M. S., Birckbichler, P. & Gliemann, J., 1997, I: J Pathol. 183, s. 398-403 6 s.

Molecular identification of anovel candidate sorting receptor purified from human brain by receptor-associated protein affinity chromatography

Petersen, C. M., Nielsen, M. S., Nykjær, A., Jacobsen, L., Tommerup, N., Rasmussen, H., Røigaard, H., Gliemann, J., Madsen, P. S. & Moestrup, S. K., 1997, I: Journal of Biological Chemistry. 272, s. 3599-3605 7 s.

Segments in the C-terminal folding domain of lipoprotein lipase important for binding to the low density lipoprotein receptor-related protein and to heparan sulfate proteoglycans

Nielsen, M. S., Brejning, J., García, R., Zhang, H., Hayden, M. R., Vilaró, S. & Gliemann, J., 1997, I: Journal of Biological Chemistry. 272, 9, s. 5821-5827 7 s.

Cloning and sequencing of a human cDNA encoding a putative transcription factor containing a bromodomain

Nielsen, M. S., Petersen, C. M., Gliemann, J. & Madsen, P. S., 1996, I: Biochim. Biophys. Acta.. 1306, s. 14-16 3 s.

Hepatic lipase mediates the uptake of chylomicrons and β-VLDL into cells via the LDL receptor-related protein (LRP)

Krapp, A., Ahle, S., Kersting Hua, Y., Kneser, K., Nielsen, M. S., Gliemann, J. & Beisiegel, U., 1996, I: J. Lipid Res.. 37, s. 926-936 11 s.

The receptor-associated protein (RAP) binds calmodulin and is phosphorylated by calmodulin-dependent kinase II

Petersen, C. M., Ellgaard, L., Nykjær, A., Vilhardt, F., Vorum, H., Thøgersen, H. C., Nielsen, M. S., Jacobsen, C., Moestrup, S. K. & Gliemann, J., 1996, I: E M B O Journal. 15, 16, s. 4165-4173

cDNA expression and human two-dimentional gel protein databases: Towards integrating DNA and protein information

Leffers, H., Dejgaard, K., Honore, B., Madsen, P. S., Nielsen, M. S. & Celis, J., 1996, I: Electrophoresis. 17, s. 1713-1719 7 s.

Analysis of ligand binding to the α2-macroglobulin receptor/low density lipoprotein receptor-related protein

Nielsen, M. S., Nykjær, A., Warshawsky, I., Schwartz, A. L. & Gliemann, J., 1995, I: Journal of Biological Chemistry. 270, s. 23713-23719 7 s.

Analysis of the binding of pro-urokinase-plasminogen activator inhibitor-1 complex to the low density lipoprotein receptor-related protein using a Fab fragment selected from a phage-displayed Fab library

Horn, I. R., Moestrup, S. K., van den Berg, B. M. M., Pannekoek, H., Nielsen, M. S. & van Zonneveld, A. J., 1995, I: Journal of Biological Chemistry. 270, s. 11770-11775 6 s.

α2-macroglobulin receptor mediates binding and cytotoxicity of plant ribosome-inactivating proteins

Cavallaro, U., Nykjær, A., Nielsen, M. S. & Soria, M. R., 1995, I: F E B S Journal. 232, s. 165-171 7 s.

A C-terminal fragment of lipoprotein lipase binds to LDL receptor-related protein and inhibits lipase-mediated uptake of β-VLDL lipoprotien particles

Nykjær, A., Nielsen, M. S., Meyer, M., Røigaard, H., Etzerodt, M., Lookene, A., Beisiegel, U., Olivecrona, G. & Gliemann, J., 1994, I: Journal of Biological Chemistry. 267, s. 31747-31755 9 s.

The α2-macroglobulin receptor/low density lipoprotein receptor-related protein. Binding and endocytosis of fluid-phase and membrane-associated ligands

Gliemann, J., Nykjær, A., Petersen, C. M., Jørgensen, K. E., Nielsen, M. S., Andreasen, P., Christensen, E. I., Lookene, A., Olivecrona, G. & Moestrup, S. K., 1994, I: Ann. N. Y. Acad. Sci.. 737, s. 20-38 19 s.

Human cellular protein patterns and their link to genome DNA mapping and sequencing data: Towards an integrated approach to the study of gene expression

Celis, J., Rasmussen, H. H., Leffers, H., Madsen, P. S., Honore, B., Dejgaard, K., Gromov, P., Olsen, E., Hoffmann, H. J., Nielsen, M. S., Gesser, B. & Vandekerckhove, J., 1993, I: Genetic Engineering. 15, s. 21-40 20 s.

Identification of two human Rho GDP-dissociation inhibitor protein whose overexpression leads to disruption of the acting cytoskeleton

Leffers, H., Nielsen, M. S., Andersen, A. H., Honore, B., Madsen, P. S., Vandekerckhove, J. & Celis, J., 1993, I: Exp. Cell Res.. 209, s. 165-174 10 s.

The human keratinocyte two-dimentional gel protein database: Update 1993

Celis, J., Rasmussen, H. H., Olsen, E., Madsen, P. S., Leffers, H., Honore, B., Dejgaard, K., Gromov, P., Hoffmann, H. J., Nielsen, M. S., Vassilev, A., Vintermyr, O., Hao, J., Celis, A., Basse, B., Lauridsen, J. B., Ratz, G. P., Andersen, A. H., Walbum, E., Nielsen, I. K., Puype, M., Van Damme, J. & Vandekerckhove, J., 1993, I: Electrophoresis. 14, s. 1091-1198 108 s.

The human keratinocyte two-dimensional gel protein database: Update 1992: Towards an integrated approach to the study of cell proliferation, differentiation and skin diseases

Celis, J., Rasmussen, H. H., Madsen, P. S., Leffers, H., Honore, B., Dejgaard, K., Gesser, B., Olsen, E., Gromov, P., Hoffmann, H. J., Nielsen, M. S., Celis, A., Lauridsen, J. B., Basse, B., Ratz, G. P., Andersen, A. H., Walbum, E., Nielsen, I. K., Nielsen, H., Puype, M., Van Damme, J. & Vandekerckhove, J., 1992, I: Electrophoresis. 13, s. 893-959 67 s.

Aktiviteter

Dansk Magisterforening (Ekstern organisation)

Morten Schallburg Nielsen (Medlem)

1 maj 2006 → …

Dansk Magisterforenings lokalklub ved Aarhus Universitet- Naturvidenskab og Sundhedsvidenskab (Ekstern organisation)

Morten Schallburg Nielsen (Medlem)

1 feb. 2006 → 1 feb. 2008

Universitetslærelandsklubben (Ekstern organisation)

Morten Schallburg Nielsen (Medlem)

26 jan. 2006 → 1 jan. 2010