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Morten L. Kringelbach

Connectome-harmonic decomposition of human brain activity reveals dynamical repertoire re-organization under LSD

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  • Selen Atasoy, Universitat Pompeu Fabra, Barcelona
  • ,
  • Leor Roseman, Imperial College London
  • ,
  • Mendel Kaelen, Imperial College London
  • ,
  • Morten L. Kringelbach
  • Gustavo Deco, Universitat Pompeu Fabra, Barcelona, Theoretical and Computational Neuroscience Group, Center of Brain and Cognition, Universitat Pompeu Fabra, 08018 Barcelona, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), 08010 Barcelona, Spain., Max Planck Institute for Human Cognitive and Brain Sciences, Monash University
  • ,
  • Robin L. Carhart-Harris, Imperial College London

Recent studies have started to elucidate the effects of lysergic acid diethylamide (LSD) on the human brain but the underlying dynamics are not yet fully understood. Here we used 'connectome-harmonic decomposition', a novel method to investigate the dynamical changes in brain states. We found that LSD alters the energy and the power of individual harmonic brain states in a frequency-selective manner. Remarkably, this leads to an expansion of the repertoire of active brain states, suggestive of a general re-organization of brain dynamics given the non-random increase in co-activation across frequencies. Interestingly, the frequency distribution of the active repertoire of brain states under LSD closely follows power-laws indicating a re-organization of the dynamics at the edge of criticality. Beyond the present findings, these methods open up for a better understanding of the complex brain dynamics in health and disease.

OriginalsprogEngelsk
Artikelnummer17661
TidsskriftScientific Reports
Vol/bind7
Nummer1
ISSN2045-2322
DOI
StatusUdgivet - 1 dec. 2017

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