MUNIX and incremental stimulation MUNE in ALS patients and control subjects

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Jasna Furtula, Danmark
  • Birger Johnsen
  • Peter Broegger Christensen, Danmark
  • Kirsten Pugdahl
  • Carsten Bisgaard, Department of Neurology, Vejle Hospital, Vejle, Danmark
  • Mette-Kirstine Christensen, Institut for Klinisk Medicin - Neurologisk Afdeling, Aalborg Sygehus Nord, Danmark
  • Jens Arentsen, Department of Neurology, Holstebro Hospital, Holstebro, Danmark
  • Morten Frydenberg, Danmark
  • Anders Fuglsang-Frederiksen
OBJECTIVE: This study compares the new Motor Unit Number Estimation (MUNE) technique, MUNIX, with the more common incremental stimulation MUNE (IS-MUNE) with respect to reproducibility in healthy subjects and as potential biomarker of disease progression in patients with ALS. METHODS: Thirteen ALS patients and 48 control subjects were prospectively investigated - both groups were studied with MUNIX and IS-MUNE applied on the abductor digiti minimi (ADM) muscle. Additional retest was performed on 14 control subjects. Follow-up tests were carried out on 6 patients. The analysis included measures of reproducibility (Intraclass Correlation Coefficient (ICC)) and diagnostic performance (Receiver Operating Characteristic (ROC) analysis). RESULTS: Test-retest reproducibility was low to moderate for MUNIX and IS-MUNE (ICC=0.38 and 0.56, respectively). Repeated MUNIX and IS-MUNE measurements on the same subject had a mean percentage difference (MPD) of 20% and 46%, respectively (p=0.039). In the control group, the coefficient of variation was markedly lower for MUNIX than for IS-MUNE (26% and 44%, respectively, p
TidsskriftClinical Neurophysiology
Sider (fra-til)610-618
StatusUdgivet - mar. 2013

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