Long-term treatment of ADHD with stimulants: A large observational study of real-life patients

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Shelagh G. Powell, Aarhus University Hospital, Centre for Child and Adolescent Psychiatry, Danmark
  • Per Hove Thomsen
  • Morten Frydenberg, Danmark
  • Helle Rasmussen, Danmark
  • Børne- og Ungdomspsykiatrisk Regionscenter, Risskov
  • Afdeling for Biostatistik
Objective: To evaluate 410 real-life patients treated with stimulants and assessed systematically over several years.
Method: Naturalistic observational study. A database was compiled on the basis of a review of the medical charts of
patients attending a specialized ADHD clinic. Results: The diversity of ADHD patients was evident from the comorbidity,
age at start, comedication, and treatment needs over time. Dosages corresponded to guidelines in most patients, but some
needed higher dosages or got along on lower dosages for long periods. Age at start and comorbidity influenced dosage,
and dosage was associated to differential outcome groups. Conclusion: The study findings underscored the diversity of
ADHD patients and that individual factors should be taken into account when tailoring individual treatment schedules.
Findings further showed that stimulant dosages are dynamic over time and depend on individual factors, that individual
factors influence outcome, and that patients with ADHD should be individually monitored and stimulant dosages adjusted
continuously. (J. of Att. Dis. 2011; 15(6) 439-451)
TidsskriftJournal of Attention Disorders
Sider (fra-til)439-451
Antal sider4
StatusUdgivet - 2011


  • ADHD

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