Coffee Consumption During Pregnancy and Birth Weight: Does Smoking Modify the Association?

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Background: A previous randomized trial demonstrated an association between coffee intake and birth weight in smokers only. This could be a chance finding or because smoking interferes with caffeine metabolism. This study assessed the association between coffee intake during pregnancy and birth weight and whether it was modified by the mothers' smoking habits.

Methods: In the Danish National Birth Cohort, coffee intake and smoking during pregnancy were recorded prospectively in 89,539 pregnancies that ended with live born singletons. Information on birth weight was obtained from the Danish Medical Birth Register. For a total of 71,000 pregnancies, complete information was available on coffee intake and all covariates for the second trimester.

Results: Second-trimester coffee intake was associated with reduced birth weight in a dose–response pattern for non-smokers and smokers (9 g/cup/day). Compared to non-coffee drinkers, intake of eight or more cups of coffee per day was associated with an adjusted birth weight difference of −65 g [95% confidence interval (CI) −92 to −39] for non-smokers and −79 g [95% CI −124 to −34] for women smoking more than 10 cigarettes per day. Women drinking eight or more cups of coffee per day had a higher risk of giving birth to a child small for gestational age (adjusted odds ratio=1.51 [95% CI 1.21–1.88]). These associations were found among both smokers and non-smokers.

Conclusion: Coffee intake during pregnancy is associated with reduced birth weight in smokers as well as non-smokers, and may increase the risk of giving birth to small for gestational age children, but the association is small for intakes of coffee of less than eight cups per day.
TidsskriftJournal of Caffeine Research
Sider (fra-til)65-72
Antal sider8
StatusUdgivet - 26 maj 2015

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