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Mille Thastum
Microstructural changes in the brain after long-term post-concussion symptoms: A randomized trial
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
DOI
- https://doi.org/10.1002/jnr.24773
Forlagets udgivne version
- Erhard Trillingsgaard Næss-Schmidt
- Jakob Udby Blicher
- Mille Møller Thastum
- Charlotte Ulrikka Rask
- Susanne Wulff Svendsen, Københavns Universitet ,
- Andreas Schröder
- Astrid Høeg Tuborgh ,
- Leif Østergaard
- Ryan Sangill
- Torben Lund
- Sune Nørhøj Jespersen
- Asger Roer Pedersen
- Brian Hansen
- Simon Fristed Eskildsen
- Jørgen Feldbæk Nielsen
- Institut for Klinisk Medicin - Hammel Neurocenter, Universitetsklinik for Neurorehabilitering
- Institut for Klinisk Medicin - Center for Funktionelt Integrativ Neurovidenskab (CFIN)
- Institut for Klinisk Medicin - Børne- og Ungdomspsykiatri
- Institut for Klinisk Medicin - Forskningsklinikken for Funktionelle Lidelser
- Institut for Klinisk Medicin - Røntgen og Skanning
- Institut for Klinisk Medicin - Center for Funktionelt Integrativ Neurovidenskab-SKS
- Institut for Fysik og Astronomi
A recent randomized controlled trial in young patients with long-term post-concussion symptoms showed that a novel behavioral intervention "Get going After concussIoN" is superior to enhanced usual care in terms of symptom reduction. It is unknown whether these interventional effects are associated with microstructural brain changes. The aim of this study was to examine whether diffusion-weighted MRI indices, which are sensitive to the interactions between cellular structures and water molecules' Brownian motion, respond differently to the interventions of the above-mentioned trial and whether such differences correlate with the improvement of post-concussion symptoms. Twenty-three patients from the intervention group (mean age 22.8, 18 females) and 19 patients from the control group (enhanced usual care) (mean age 23.9, 14 females) were enrolled. The primary outcome measure was the mean kurtosis tensor, which is sensitive to the microscopic complexity of brain tissue. The mean kurtosis tensor was significantly increased in the intervention group (p = 0.003) in the corpus callosum but not in the thalamus (p = 0.78) and the hippocampus (p = 0.34). An increase in mean kurtosis tensor in the corpus callosum tended to be associated with a reduction in symptoms, but this association did not reach significance (p = 0.059). Changes in diffusion tensor imaging metrics did not differ between intervention groups and were not associated with symptoms. The current study found different diffusion-weighted MRI responses from the microscopic cellular structures of the corpus callosum between patients receiving a novel behavioral intervention and patients receiving enhanced usual care. Correlations with improvement of post-concussion symptoms were not evident.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Journal of Neuroscience Research |
| Vol/bind | 99 |
| Nummer | 3 |
| Sider (fra-til) | 872-886 |
| Antal sider | 15 |
| ISSN | 0360-4012 |
| DOI | |
| Status | Udgivet - mar. 2021 |
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