Institut for Statskundskab

The Risk-Stratified Osteoporosis Strategy Evaluation study (ROSE): A Randomized Prospective Population-Based Study. Design and Baseline Characteristics

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review


  • Katrine Hass Rubin
  • ,
  • Teresa Holmberg
  • ,
  • Mette Juel Rothmann
  • ,
  • Mikkel Høiberg
  • ,
  • Reinhard Barkmann
  • ,
  • Jeppe Gram
  • ,
  • Anne Pernille Hermann, Odense University Hospital, Danmark
  • Mickael Bech, University of Southern Denmark
  • ,
  • Ole Rasmussen, Sygehus Lillebælt, Kolding, Danmark
  • Claus C Glüer
  • ,
  • Kim Brixen, University of Southern Denmark, Danmark
The risk-stratified osteoporosis strategy evaluation study (ROSE) is a randomized prospective population-based study investigating the effectiveness of a two-step screening program for osteoporosis in women. This paper reports the study design and baseline characteristics of the study population. 35,000 women aged 65-80 years were selected at random from the population in the Region of Southern Denmark and-before inclusion-randomized to either a screening group or a control group. As first step, a self-administered questionnaire regarding risk factors for osteoporosis based on FRAX(®) was issued to both groups. As second step, subjects in the screening group with a 10-year probability of major osteoporotic fractures ≥15 % were offered a DXA scan. Patients diagnosed with osteoporosis from the DXA scan were advised to see their GP and discuss pharmaceutical treatment according to Danish National guidelines. The primary outcome is incident clinical fractures as evaluated through annual follow-up using the Danish National Patient Registry. The secondary outcomes are cost-effectiveness, participation rate, and patient preferences. 20,904 (60 %) women participated and included in the baseline analyses (10,411 in screening and 10,949 in control group). The mean age was 71 years. As expected by randomization, the screening and control groups had similar baseline characteristics. Screening for osteoporosis is at present not evidence based according to the WHO screening criteria. The ROSE study is expected to provide knowledge of the effectiveness of a screening strategy that may be implemented in health care systems to prevent fractures.
TidsskriftCalcified Tissue International
Sider (fra-til)167-179
Antal sider13
StatusUdgivet - 2015
Eksternt udgivetJa

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