Institut for Statskundskab

Point-of-Care Phalangeal Bone Mineral Density Measurement Can Reduce the Need of Dual-Energy X-Ray Absorptiometry Scanning in Danish Women at Risk of Fracture

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  • Teresa Holmberg, Statens Institut for Folkesundhed
  • ,
  • Mickael Bech, KORA, Danish Institute for Local and Regional Government Research
  • ,
  • Jeppe Gram, Hospital of Southwest Denmark
  • ,
  • Anne Pernille Hermann, Odense Universitetshospital
  • ,
  • Katrine Hass Rubin, Syddansk Universitet
  • ,
  • Kim Brixen, Odense Universitetshospital

Identifying persons with a high risk of osteoporotic fractures remains a challenge. DXA uptake in women with elevated risk of osteoporosis seems to be depending on distance to scanning facilities. This study aimed to investigate the ability of a small portable scanner in identifying women with reduced bone mineral density (BMD), and to define triage thresholds for pre-selection. Total hip and lumbar spine BMD was measured by dual-energy X-ray absorptiometry and phalangeal BMD by radiographic absorptiometry in 121 Danish women with intermediate or high 10-year fracture probability (aged 61–81 years). Correlation between the two methods was estimated using correlation coefficient (r) and Bland–Altman plots. A moderate correlation between phalangeal BMD versus total hip (r = 0.47) and lumbar spine (r = 0.51), and an AUC on 0.80 was found. The mean difference between phalangeal T score and total hip T score/lumbar spine T score was low, and ranged from −0.26 SD to −0.31 SD depending on site and reference database used for calculation of T scores, but, large variation was seen at an individual level. When applying a triage approach approx. one-third of all DXA scan could be avoided and only 6 % of women in the low-risk group would be false negatives.

TidsskriftCalcified Tissue International
Sider (fra-til)244-252
Antal sider9
StatusUdgivet - 2016
Eksternt udgivetJa

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