Mette Meinert

Botulinum toxin-treatment of localized provoked vulvodynia refractory to conventional treatment

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  • Thomas Hedebo Hansen, Department of Obstetrics and Gynecology, Aarhus University Hospital, Denmark. Electronic address: thomashedebo@hotmail.com.
  • ,
  • Rikke Guldberg
  • Mette Meinert

INTRODUCTION: We wanted to evaluate the efficacy of botulinum toxin type A (botulinum toxin) treatment on vulvodynia refractory to conventional treatment.

MATERIAL AND METHODS: A follow-up study on botulinum toxin treatment was conducted at Aarhus University Hospital (n = 109). Seventy-nine completed the follow-up. The women included had localized provoked vulvodynia, refractory to first line treatment and were treated with 100*I.E. botulinum toxin electromyography (EMG) guided in the musculus levator ani in the period from March 2012 to May 2015(1). The outcome measures were: Dyspareunia, Negative Interference in Quality of Life (NIQL) and cotton swab test all rated on the numerical rating scale (NRS) and active vitae sexualis. Follow-up was conducted at six months.

RESULTS: The women experienced significant improvements on, dyspareunia, which decreased to 5.82 from 7.82 (p < 0.01), NIQL to 6.19 from 7.88 (p < 0.01) and the cotton swab test to 5.50 from 6.81 (p < 0.01). No significant effect on Active Vitae Sexualis was found (p = 0.25).

CONCLUSION: Women injected with 100*I.E. botulinum toxin EMG guided, diagnosed with localized provoked vulvodynia refractory to conventional non invasive treatment, had a reduction in dyspareunia and improved quality of life. Injection of botulinum toxin had no significant effect on vitae sexualis. Randomized controlled trials are, however, much needed.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Obstetrics & Gynecology and Reproductive Biology
Vol/bind234
NummerMarch
Sider (fra-til)6-9
Antal sider4
ISSN0301-2115
DOI
StatusUdgivet - 2019

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