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Mette Lausten Hansen

Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up

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Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up. / Ramlau-Hansen, Cecilia; Toft, Gunnar; Jensen, Morten Søndergaard; Strandberg-Larsen, Katrine; Hansen, Mette Lausten; Olsen, Jørn.

I: Human Reproduction, Bind 25, Nr. 9, 09.2010, s. 2340-5.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{21b58840881511df8c1a000ea68e967b,
title = "Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up",
abstract = "BACKGROUND Concurrent alcohol exposure has been associated with reduced fecundity, but no studies have estimated the effect of prenatal alcohol exposure on male fecundity. The aim of this study was to investigate the association between maternal alcohol consumption during pregnancy, semen quality and levels of reproductive hormones in young, adult men. METHODS From a Danish pregnancy cohort established in 1984-1987, 347 sons were selected for a follow-up study conducted in 2005-2006. Semen and blood samples were analyzed for conventional semen characteristics and reproductive hormones, respectively, and results were related to prospectively self-reported information on maternal alcohol consumption during pregnancy. RESULTS The sperm concentration decreased with increasing prenatal alcohol exposure. The adjusted mean sperm concentration among sons of mothers drinking >/=4.5 drinks per week during pregnancy was 40 (95{\%} CI: 25-60) millions/ml. This concentration was approximately 32{\%} lower compared with men exposed to <1.0 drink per week, who had a sperm concentration of 59 (95{\%} CI: 44-77) millions/ml. The semen volume and the total sperm count were also associated with prenatal alcohol exposure; sons prenatally exposed to 1.0-1.5 drinks per week had the highest values. No associations were found for sperm motility, sperm morphology or any of the reproductive hormones, including testosterone. CONCLUSIONS These results indicate that prenatal exposure to alcohol may have a persisting adverse effect on Sertoli cells, and thereby sperm concentration. If these associations are causal they could explain some of the reported differences between populations and long-term changes in semen quality.",
author = "Cecilia Ramlau-Hansen and Gunnar Toft and Jensen, {Morten S{\o}ndergaard} and Katrine Strandberg-Larsen and Hansen, {Mette Lausten} and J{\o}rn Olsen",
year = "2010",
month = "9",
doi = "10.1093/humrep/deq140",
language = "English",
volume = "25",
pages = "2340--5",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "Oxford University Press",
number = "9",

}

RIS

TY - JOUR

T1 - Maternal alcohol consumption during pregnancy and semen quality in the male offspring: two decades of follow-up

AU - Ramlau-Hansen, Cecilia

AU - Toft, Gunnar

AU - Jensen, Morten Søndergaard

AU - Strandberg-Larsen, Katrine

AU - Hansen, Mette Lausten

AU - Olsen, Jørn

PY - 2010/9

Y1 - 2010/9

N2 - BACKGROUND Concurrent alcohol exposure has been associated with reduced fecundity, but no studies have estimated the effect of prenatal alcohol exposure on male fecundity. The aim of this study was to investigate the association between maternal alcohol consumption during pregnancy, semen quality and levels of reproductive hormones in young, adult men. METHODS From a Danish pregnancy cohort established in 1984-1987, 347 sons were selected for a follow-up study conducted in 2005-2006. Semen and blood samples were analyzed for conventional semen characteristics and reproductive hormones, respectively, and results were related to prospectively self-reported information on maternal alcohol consumption during pregnancy. RESULTS The sperm concentration decreased with increasing prenatal alcohol exposure. The adjusted mean sperm concentration among sons of mothers drinking >/=4.5 drinks per week during pregnancy was 40 (95% CI: 25-60) millions/ml. This concentration was approximately 32% lower compared with men exposed to <1.0 drink per week, who had a sperm concentration of 59 (95% CI: 44-77) millions/ml. The semen volume and the total sperm count were also associated with prenatal alcohol exposure; sons prenatally exposed to 1.0-1.5 drinks per week had the highest values. No associations were found for sperm motility, sperm morphology or any of the reproductive hormones, including testosterone. CONCLUSIONS These results indicate that prenatal exposure to alcohol may have a persisting adverse effect on Sertoli cells, and thereby sperm concentration. If these associations are causal they could explain some of the reported differences between populations and long-term changes in semen quality.

AB - BACKGROUND Concurrent alcohol exposure has been associated with reduced fecundity, but no studies have estimated the effect of prenatal alcohol exposure on male fecundity. The aim of this study was to investigate the association between maternal alcohol consumption during pregnancy, semen quality and levels of reproductive hormones in young, adult men. METHODS From a Danish pregnancy cohort established in 1984-1987, 347 sons were selected for a follow-up study conducted in 2005-2006. Semen and blood samples were analyzed for conventional semen characteristics and reproductive hormones, respectively, and results were related to prospectively self-reported information on maternal alcohol consumption during pregnancy. RESULTS The sperm concentration decreased with increasing prenatal alcohol exposure. The adjusted mean sperm concentration among sons of mothers drinking >/=4.5 drinks per week during pregnancy was 40 (95% CI: 25-60) millions/ml. This concentration was approximately 32% lower compared with men exposed to <1.0 drink per week, who had a sperm concentration of 59 (95% CI: 44-77) millions/ml. The semen volume and the total sperm count were also associated with prenatal alcohol exposure; sons prenatally exposed to 1.0-1.5 drinks per week had the highest values. No associations were found for sperm motility, sperm morphology or any of the reproductive hormones, including testosterone. CONCLUSIONS These results indicate that prenatal exposure to alcohol may have a persisting adverse effect on Sertoli cells, and thereby sperm concentration. If these associations are causal they could explain some of the reported differences between populations and long-term changes in semen quality.

U2 - 10.1093/humrep/deq140

DO - 10.1093/humrep/deq140

M3 - Journal article

C2 - 20587536

VL - 25

SP - 2340

EP - 2345

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 9

ER -