Mette Bjerre

High osteopontin levels predict long-term outcome after STEMI and primary percutaneous coronary intervention

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Mette Bjerre
  • Sune Folke Pedersen, Department of Cardiology P, Gentofte University Hospital, Copenhagen, Denmark., Danmark
  • Rasmus Møgelvang, Cardiology Section, Department of Internal Medicine , Holbaek Hospital , Holbaek , Denmark., Danmark
  • Søren Lindberg, Department of Cardiology P, Gentofte University Hospital, Copenhagen, Denmark.
  • ,
  • Jan Jensen, Institute of Surgery and Internal Medicine, Faculty of Health Sciences, University of Copenhagen, Danmark
  • Søren Galatius, Department of Cardiology P, Gentofte University Hospital, Copenhagen, Denmark., Danmark
  • Allan Flyvbjerg, Danmark
BACKGROUND: Osteopontin (OPN), a multifunctional glycoprotein, has recently been found to be an important player in cardiovascular diseases and to be implicated in a variety of acute as well as chronic inflammatory processes, including atherosclerosis. This study investigates the association between plasma OPN at admission and the long-term outcome in patients with ST segment elevation myocardial infarction (STEMI) treated with primary percutaneous coronary intervention (pPCI). METHODS: We included a total of 730 consecutive STEMI patients admitted to a single high-volume invasive heart centre between September 2006 and December 2008. Plasma OPN and high sensitivity C-reactive protein (hsCRP) were measured. RESULTS: The median follow-up time was 27 months (interquartile range: 22-33) and endpoints were all-cause mortality, re-infarction and heart failure. Even when adjusted for all baseline variables, increasing OPN was independently associated with increased all-cause mortality, and the combined endpoint, a linear increase in OPN of 10 µg/l, was associated with a hazard ratio (HR) of 1.05 (95% confidence interval (CI): 1.02-1.08; p = 0.002) for all-cause mortality and HR 1.03 (95%CI: 1.01-1.05; p = 0.047) for the combined endpoint. Importantly, OPN interacted with the predictive power of hsCRP, and the combination of high OPN levels and high hsCRP levels (>3 mg/l) were significantly associated with increased risk of all-cause mortality (HR: 2.32; CI: 1.51-3.58; p 
OriginalsprogEngelsk
TidsskriftEuropean Journal of Preventive Cardiology
Vol/bind20
Nummer6
Sider (fra-til)922-9
Antal sider7
ISSN2047-4873
DOI
StatusUdgivet - 23 apr. 2013

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